📣Preprint alert! Bacteria resist aminoglycosides by silencing misreading ribosomes—this preserves the proteome and blocks antibiotic uptake.
A new role for EF-G (fusA) in safeguarding translation. #ribosome#antibiotics#AMR
https://t.co/9g7lFB8JDp
Preprint from our collaboration with the labs of Gerry Wright and Shura Mankin @shuramankin identifying the first translation inhibitor binding to the E-site of the bacterial ribosome… https://t.co/gDSnWPSnsA
Check out our latest preprint! By investigating translation initiation kinetics in live E. coli cells we found that the IF2α isoform directly interacts with the transcription factor NusA, suggesting a novel link between transcription and translation. https://t.co/LKOWNiLY02
A very elaborate and systematic study on how EF-P is rapidly recruited 🛬to ribosomes: it goes away🛫if not needed, but fixes🛠️those that need help🆘
(also some of the best stopped-flow traces I have ever seen). Congratulations to all the authors!
https://t.co/LScmkwCWVA
There is little time left to apply for the @ERC-funded PhD and postdoc positions in my new lab in beautiful Regensburg! Check out and RT please :) @jrRNAscientists
https://t.co/t40Knh57yq
It is hard to beat nature in the design of antibiotics. In this review, we analyze the sophisticated mechanisms of many antibiotic substances with an eye toward future antibacterial drug discovery.
https://t.co/UsbyzKCcfQ
Protein synthesis in Bacillus subtilis: resolution of ribosomal stalls by ABCFs YdiF, YfmM, YfmR/Uup and YkpA/YbiT, EF-P loosing its modification but not its functionality, and a genetic interaction between EF-P and BipA! Out in @NAR_Open https://t.co/R3LcA3Ch9i
We are rapping today about arrest peptides!! Back-to-back manuscripts in @NatureComms showing how RAPP and SecM arrest peptides can stall the ribosome! SecM link here: https://t.co/yOyiZbI64r https://t.co/JqLfk5Kcx9
@GBM_eV@MpiBrain@MuenchLab Congrats to Christina Desch! I am more than happy that I also received the poster award of the #GBMCompact meeting on proteomics. It was a great meeting and a cool conference format. Many thanks to the organizers!
📢excited to share that our collaborative paper between @mpi_nat & @JagiellonskiUni is out in @NatureComms ! We used rapid #kinetics 🏃♀️, #smFRET 🔬 and #cryoEM ❄️ to investigate how m6A modification of mRNA modulates ribosomes decoding. https://t.co/t3I3hNAW70. Tweetorial 🧵:
After a long absence on twitter, we are back to share our publication with @Hashemyaser4 and @InnisLab on the regulation of the macrolide resistance translation factor MsrD. It is now published i@NatureComms https://t.co/leNBrUs96A
Our paper on dormant egg ribosomes is out now! I couldn't be more grateful to work with @llorenzoorts,@PauliGroup @HaselbachLab and so many others. I learned so much and discovered my passion for #ribosomes https://t.co/8dITd4pmfz
Thank you for your enthusiasm and support!
Our paper is out on the Structure of Escherichia coli heat shock protein Hsp15 in complex with the ribosomal 50S subunit bearing peptidyl-tRNA…great work from @HaarisAhsan and collaborators @IgnatovaLab and Tenson lab https://t.co/uHkqpuk32o
Apply: PhD position at the interface of quantitative molecualr biology and computational biophysics (see attached add), jointly supervised with my twitterless collaborator Adelaide Raguin (Uni Düsseldorf). The PhD will be working in my lab, in Hamburg. Please RT.
At its meeting on 23 June 2022, the Max Planck Society’s Senate appointed Patrick Cramer, Director at the Max Planck Institute for Multidisciplinary Sciences in Göttingen @mpi_nat, as new President-elect for the term of office from 2023 to 2029. @CramerLab #maxplanckhv2022