YoForte - Dr. Matt Boulos

AI health coaching built by a physician. Every recommendation cited to primary literature — 350+ sources. Sleep, training, nutrition. Founded by Matt Boulos, DO

[YoForte - Dr. Matt Boulos @YoForteHealth]

People obsess over the gut-brain axis, but if there were a way to prove it, I'd put my money on the MSK-Brain axis being more impactful.

[Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM @agingdoc1]

Exercise intensity modulates interorgan communication and is associated with cardiometabolic health outcomes in humans

👉 Sprint interval training, often lasting less than 5 min of total work, “results in similar, if not superior, whole-body metabolic adaptations” compared with 30 minutes of low or moderate intensity exercise.

https://t.co/O8nyLlg9ke

[YoForte - Dr. Matt Boulos @YoForteHealth]

@YounisJoseph @akiffpremjee Mouse traps were not included in this study, therefore this is not reflective of real life.

[YoForte - Dr. Matt Boulos @YoForteHealth]

https://t.co/gzLF8QIg8o

[YoForte - Dr. Matt Boulos @YoForteHealth]

@bryan_johnson I mean this is cool and all, but so would funding RCTs to actually move longevity forward.

[YoForte - Dr. Matt Boulos @YoForteHealth]

@YounisJoseph @fuqekgs 5-10% of the population is genuinely unsatisfiable whether it's personality disorders, unresolved trauma, misplaced resentment, or a host of other psychological contributors. Don't sweat the small stuff.

[YoForte - Dr. Matt Boulos @YoForteHealth]

@mansihukmani_ You have just described capitalism and how it moves society forward.

[YoForte - Dr. Matt Boulos @YoForteHealth]

@YounisJoseph Yeah, when they train the models to the benchmark, it doesn't mean they are universally capable. It's like studying for the MCAT, cool bro, you studied for the MCAT, you're not a universal genius.

[Chamath Palihapitiya @chamath]

I turn 50 today. This is a message to my kids but I offer it to you in case any of it rings useful.

I was born in Sri Lanka in 1976 in a country that, at the time, was about to enter a decades long civil war. My father was able to get stationed at the Sri Lankan High Commission in Canada for four years in the early 80s - when some of the fighting was most severe - and which from our vantage point in Canada gave us some respite from an otherwise omnipresent conflict.

He came as a diplomat but then my father filed for refugee status after four years when his life was threatened by militants. We stayed in Canada as refugees. My dad never really landed on his feet and we grew up on welfare.

My mom stepped up. She did an incredible thing and put our family on her back and kept marching forward. Sometimes the steps were very small but she always tried to keep moving forward.

I worked at Burger King starting at 14, giving my paycheck to my mom and dad to support our family in the role that I was assigned - earn enough to pay for our bus passes because we couldn’t afford a car.

I was a loser growing up. Some friends, some good memories but mostly forgettable and lonely. I wasn’t very studious but did get my act together in my final year and got into a great university.

I immigrated to the US soon after graduating and found an opportunity. Things clicked and I have been traveling a path to find myself ever since. Only in America is this possible…

I worked hard, followed the rules, paid my taxes and stayed in California out of loyalty for the opportunities it has given me despite its dysfunction.

I found my wife here. Had my kids here. Found my tribe here.

There have been some very hard times as well - deaths, divorce, financial pain, mistakes of omission and mistakes of commission. You can’t dwell on these things - they are weights that will pull you down if you’re not careful. Learn from them. Respect them. BUT MOVE ON.

To think 50 years ago I could have ever gotten a chance to meet the people I’ve met and have had the experiences I’ve had would have been mind boggling to my parents. It’s mind boggling to me now.

We forget often and try to convince others it’s not true but America truly is the best country in the world. Everything and anything is possible here. I can testify. Be grateful to be here.

This is the only place that gives EVERYONE a chance to live a great adventure. The first 50 years have been that for me - an incredible adventure.

Notice there is nothing here about accomplishments or money. Because it doesn’t matter and it won’t matter.

You will be dust in less than 100 years from now and the decision to be remembered won’t be yours so stop sweating it. It’s not in your control.

So what is in your control?

Be kind. Have fun. Work on something meaningful to you. Find your tribe. Try to find perspective. Find an incredible partner. Have a bunch of kids. Live an adventure. Forgive your parents - they were doing the best they could even if that wasn’t what you deserved.

I will do what I can to make my next 50 years a wild ride.

You should too.

I love you and thank you. ❤️

🙏🏽🙏🏽

[Eric Topol @EricTopol]

More positive news on psychedelics: psilocybin doses before cancer chemotherapy protects neurons and helps prevent peripheral neuropathy in the experimental model @ScienceMagazine
https://t.co/4ft3ywxq7l
https://t.co/pR0qANxLX6

[YoForte - Dr. Matt Boulos @YoForteHealth]

Mice get all the good drugs... oh wait!

[Lifespan @JoinLifespan]

New paper @Nature: Semaglutide recapitulates many of the benefits of caloric restriction in female mice & extends lifespan by almost 100 days. Males not yet tested for lifespan

Below: Red traces = mouse movement

[YoForte - Dr. Matt Boulos @YoForteHealth]

@MWeintraubMD @MichaelAlbertMD Anthropic will probably have a patch of some kind to connect a million personal EMR's, or something similar. Don't doubt the technology.

[YoForte - Dr. Matt Boulos @YoForteHealth]

@YounisJoseph All of the systems that have residents would not dare train their residents to compete with them!

[YoForte - Dr. Matt Boulos @YoForteHealth]

@RCarhartHarris I know what you're trying to say, but if it were a set point, it would be much more likely to persist throughout life. Perhaps, more accurate phrasing would be an original or youthful state of emotional health, that's distorted over time, that can be restored/reactivated.

[YoForte - Dr. Matt Boulos @YoForteHealth]

@Hybridathlete Yeah. Weigh and measure starches and proteins. The rest is probably not that important.

[YoForte - Dr. Matt Boulos @YoForteHealth]

@agingdoc1 There will never be a single agent that slows or reverses AZD. It is a multi-pillar disease over multiple decades.

[YoForte - Dr. Matt Boulos @YoForteHealth]

@EricTopol @JAMA_current This isn't surprising. If I order a CAC it's to use as more information to help a decision or help the patient see their risk more clearly. Cool article.

[YoForte - Dr. Matt Boulos @YoForteHealth]

@JoseAntonioPhD @AJA_Cortes This applies to pretty much everyone in the current state of the world. I agree with the sentiment though, of people staying within their realm of expertise for public comments.

[YoForte - Dr. Matt Boulos @YoForteHealth]

@YounisJoseph Sub-I performance! Probably just as valuable as the top 3-4 things here, especially if someone does s Sub-I at that institution, then it might be the most important part of the application for that applicant at that institution.

[YoForte - Dr. Matt Boulos @YoForteHealth]

@GrindandGrowFit Chest: Incline dumbbell bench.
Back: Negatie pull-ups
Legs: Bulgarian split-squats

[YoForte - Dr. Matt Boulos @YoForteHealth]

@YounisJoseph @SalaryDr With amount of procedures and call that would go into this number, this person will haven MI or a stroke within 3 years.