ZandCell

Pioneering gene therapy & regenerative medicine for radical longevity | The Longevity Institute | Est. 2005 | 🇸🇪 🇺🇸 🇬🇧

[ZandCell @ZandCell]

We are offering $10.000 to any company that can restore our company smartphone OnePlus 8 Pro mobile phone. Our entire research is locked with a 64-bit key on the phone.
@Cellebrite ?
I am getting nowhere with @oneplus @OnePlusSecurity #restore #mobilephone #smartphone

[ZandCell @ZandCell]

17 viruses that stay in your body for life:
EBV, HSV-1, HSV-2, VZV, CMV, HHV-6, HHV-7, HHV-8, HIV, HTLV-1, HTLV-2, HBV, HCV, HDV, JC, BK, HPV
Most can't be cured — only kept in check by your immune system. The hard part: clearing a virus hidden inside your own cells.

[ZandCell @ZandCell]

Do you remember when you joined X? I do! #MyXAnniversary

[Aging Science News @AgingBiology]

A Histone Code Functionally Linked to Replicative Senescence
https://t.co/Aq7MNTfile

[Eric Topol @EricTopol]

The first sleep AI foundation model for predicting diseases was published today @NatureMedicine by @james_y_zou and colleagues
https://t.co/4sITCh4K5O
With @NotebookLM I made this infographic that tells the rich story pretty well

[James Zou @james_y_zou]

Today in @NatureMedicine we report that AI can predict 130 diseases from 1 night of sleep🛌

We trained a foundation model (#SleepFM) on 585K hours of sleep recordings from 65K people—brain, heart, muscle & breathing signals combined.

AI learns the language of sleep🧵

[Aging Science News @AgingBiology]

A sex-adjusted 7-biomarker clinical aging clock for translational preventative medicine
https://t.co/DX7TodgSDm

[ZandCell @ZandCell]

Lipofuscin research needs more focus.

[Aging Science News @AgingBiology]

Lipofuscin accumulation in aging and neurodegeneration: a potential “timebomb” overlooked in Alzheimer’s disease
https://t.co/XNH6xrH4Wc

[Shawn Liu @ShawnLiu_Lab]

Our In Vivo DNA methylation editing paper is finally published. Happy to share these two transgenic mouse lines to help investigate the function of DNA methylation at gene/locus of your interest! Happy holidays!
https://t.co/8X2nguupVg

[Alex Zhavoronkov, PhD (aka Aleksandrs Zavoronkovs) @biogerontology]

Check out the top 10 advances in biotechnology in 2025 by Nature Biotechnology. Happy to see our research making the list. Hoping to make much bigger impact in 2026.

Let's collaborate and make this world a better place.

https://t.co/tdwgnNmjZl

[ZandCell @ZandCell]

Scientists identify cells by seeing how high they levitate
https://t.co/zNEwHFziQK

[GeroScience @GeroScienceAGE]

📢Arterial stiffness is associated with prefrontal cortex integrity in ageing by Rachael Yu & Sharon L. Naismith (@Prof_Naismith) et al.

👉 https://t.co/RHB75hZEZk

This study shows that among older adults, greater arterial stiffness (measured by pulse-wave velocity) is linked with reduced cortical thickness in the prefrontal cortex (PFC) — a brain region critical for executive function and cognition.

These findings suggest that vascular aging may contribute to structural brain changes, reinforcing the importance of vascular health for healthy brain aging.

#Aging #VascularHealth #BrainAging #Geroscience

[GeroScience @GeroScienceAGE]

🧬 New Open Access Publication!

“Gut microbiome signatures predict cognitive impairment in older cancer survivors” by Brandi C. Miller & Shalini Jain et al.

👉 https://t.co/GujXWTFROO

This study finds that older cancer survivors (≥ 60 years) have distinct gut microbiome signatures — including specific bacterial taxa and metabolic pathways — that associate with cognitive impairment. Compared to non-cancer older adults, survivors with cognitive impairment show reduced beneficial microbes and depletion of microbial neurotransmitter-synthesis pathways.

These findings support a potential gut–brain axis link in cancer survivors, indicating the microbiome might help predict or even contribute to cognitive decline in aging individuals post-cancer treatment.

#AgingResearch #GutMicrobiome #CognitiveImpairment #CancerSurvivors #Geroscience

[American Aging Association @americanaging]

New research identifies a unique T-helper cell subset that increases with age and may help clear senescent cells — a potential lever for slowing biological aging.
At #AGE, we champion discoveries that reveal how the immune system shapes longevity. https://t.co/jQDKor75up
#AGE2026

[Nabla Bio @nablabio]

Today we’re thrilled to announce JAM-2 — the first AI model capable of generating drug-quality antibodies straight from the computer, with industry-leading success rates.

> Drug-like affinities: Picomolar to single-digit nanomolar antibody binders for half of 26 targets while testing <45 designs each.

> Unlocking hard targets: Up to 11% success rate for direct on-cell GPCR binders; top antibody hits in the single-digit nanomolar range.

> Unprecedented epitope breadth: JAM-2 routinely designed antibodies that hit 30–70% of user-defined epitopes, now enabling intentional design of biology — not chance discovery.

> Drug-like developability: Over 50% of antibody designs passed core industry developability criteria with zero optimization.

> Massive leverage: A four-person team prosecuted 16 targets in parallel in < 1 month.

JAM-2 is the first de novo antibody design capability ready for front-line use in drug discovery, matching or surpassing traditional discovery approaches.

We’re already deploying JAM-2 with multiple large pharma partners and seeing excellent results.

If you’re interested in partnering on molecule development or accessing JAM-2, contact [email protected].

Read more in our whitepaper (link below)

[New Scientist @newscientist]

Our bond with cats – which has seen them go from hunter to house pet – may be more diverse than with any other animal. And Jerry D. Moore's Cat Tales: A history rounds up the lot, says Bethan Ackerley https://t.co/ydycg0mUMh

[ZandCell @ZandCell]

Brain disorders such as dementia are linked to viral infections. Scientists are finding out why https://t.co/hrUWOmGfY8

[ZandCell @ZandCell]

Active agent against cancer metastasis discovered: Adhibin prevents migration and attachment to other cells https://t.co/9B52BBnW7l

[ZandCell @ZandCell]

@58bugeye Nonsense

[ZandCell @ZandCell]

@PrimeMedicine Congratulations 🥳

[ZandCell @ZandCell]

Check out this job at ZandCell:
VPN/Internet Gateway Software Developer https://t.co/o8gUahYCZ0
#jobs #jobsearch #remotejobs #DevOps #Python