Turns out some virus's get stuck in late endosomes under high membrane tension! Making them unable to infect cells!
Congrats to the Tklab Virus Team for our paper @PNASNews. Live 3D LLSM imaging + single cell infection assay! @harvardmed@BostonChildrens
https://t.co/2kMVT8rU1V
How much can be extracted from diffusion of single molecules? Here we show diffusion can reveal viral escape to the cytosol, the cellular location of clathrin coated pits, and can encode biomolecular identity. Great collab @NHatzakis@CHEMUCPH and @KirchhausenLab at @harvardmed
Research Highlight by @rita_strack on two papers from the Krishnan lab @KrishnanYamuna on DNA nanodevices for studying subcellular metal ion dynamics.
Highlight: https://t.co/9B9jJRJ1Ea
Original papers in thread.
We are looking for graduate students and postdoc to start in 2023! The project will be related to my recently awarded NIH-MIRA project about subcellular imaging tools development and cell pathway investigation. Please retweet and share widely!
https://t.co/djEBUuc5qM
Excited to share a new preprint from a wonderful collaboration with the Brunger lab. We found that extending the length of HR2 domain inhibitory peptides have a 100-fold increase in inhibition of SARS-CoV-2 infection.
https://t.co/ntQpasiQ3D
We are thrilled to share our latest pre-print: Deep neural network Automated Segmentation of cellular structures in volume Electron Microscopy (ASEM). Congrats to all co-authors, including @bengallusser@galenes@martweig! https://t.co/HFJNIJCx4x
Exciting new paper describing a broadly neutralizing antibody against all known SARS-CoV-2 variants from Sai Luo and Fred Alt that our lab was excited to collaborate with them on! https://t.co/ytW9p1m2Qf
We are hiring! We are looking for a postdoc with expertise in virology and cell biology to study viral entry of SARS-CoV-2 and AAV using advance imaging. Available Now. Please share!
https://t.co/xaEcMEcPJN
We are hiring! We are seeking a highly motivated individual with specific expertise in optics, fluorescence imaging, and (useful but not required) electron microscopy. Available now. Please share! https://t.co/xaEcMEcPJN
We are thrilled to share our latest paper on @Dev_Cell! In this study we show that octameric subassemblies of outer and inner nuclear pore rings remain intact in the mitotic endoplasmic reticulum after nuclear pore complexes disassembly during prophase.
Story time! Single neurons in the brain can’t be depended on for reliable information. Here are some neurons from our recent study, recorded twice in response to the same visual stimuli. Different neurons are active at different times!
https://t.co/7wuoVLuzYy