Kanokpol Aphicho

Pharmacist by training & Self-proclaimed Chemical Biologist / Chem Grad @UChicago

[Nature Chemical Biology @nchembio]

Nuclear reactive electrophilic stress suppresses translation through HNEylation at C436 of NCBP1, triggering alternative splicing of S6K1, a key regulator of translation

https://t.co/FLHyV6nK0r

[Asian Chemical Biology Initiative @asianchembiol]

🔬Thai students & faculty — interested in pursuing an advanced degree in chemical biology?
Join the ACBI 2026 Chiang Mai Tutorial & Interview to explore research paths, study-abroad opportunities in Asia & 1-on-1 faculty interviews!
⏰ Apply by Dec 13 → https://t.co/cPuGj4v6B8

[J. Am. Chem. Soc. @J_A_C_S]

Discovery of Macrocyclic Peptide Binders, Covalent Modifiers, and Degraders of a Structured RNA by mRNA Display | Journal of the American Chemical Society @UChicago @UChiChemistry @czbiohub https://t.co/jjA2eaCwrL

[Weixin Tang @WeixinT]

This week we publish in @NatureBiotech "High-precision cytosine base editors by evolving nucleic-acid-recognition hotspots in deaminase". In this work, we show that both nucleotide and context specificity of deaminases can be reprogrammed by hotspot-focused directed evolution 1/n

[Nature Biotechnology @NatureBiotech]

High-precision cytosine base editors by evolving nucleic-acid-recognition hotspots in deaminase https://t.co/jSUio33Uqq

[Cholpisit Ice Kiattisewee @theicechol]

Here is @Synbio4allA‘s new project on Plant SynBio education in Africa. We applied for a small grant and received ~70% of seed funds. However, the rest needs to be crowdfunded to secure this grant.
To support the project, see🧵or🔗for more info. https://t.co/NFHmMFIJAT

[Neil Shubin @NeilShubin]

Gene editing technology began by people studying salt marshes. Ozempic began by folks studying the venom of Gila monsters. Support for basic science has empowered us to understand our world. Tethering it to applications health has transformed and saved countless lives.

[Claire Chewapreecha @chewapreecha]

Conducting research in LMICs is undeniably challenging, with brain drain often surpassing reverse brain drain. Grateful to
@NatureRevMicro for the opportunity to share an opinion discussing both the difficulties and rewards of working in this space. https://t.co/jzbdNGYjxr [1/2]

[Alice Ting @aliceyting]

In my several decades in science, few moments have been as seismic as when AlphaFold burst onto the scene (seeing the first structure of a K+ ion channel, from Rod MacKinnon, was up there too). We rushed to fold every protein we had been working on, that had no structure, and suddenly so many things made sense. AF, then AF2 and AF3, are daily workhorses in our business of protein engineering.

And I am beyond thrilled that my friend and collaborator David Baker has also received the prize. One of the projects I’m most proud of was a computational design collaboration with him to produce a resorufin fluorophore ligase, and it was miraculous when the crystal structure matched his computational design exactly (https://t.co/qYfPbonK9b). We use the tools David’s lab has produced, such as proteinMPNN and RFDiffusion, daily. As incredible as David’s contributions have been, I feel that his best work is ahead of him.

[Rena Ren @JingyiRen]

Spatial omics technology is transforming our understanding of in situ RNA biology. We are grateful for the opportunity to publish this review in @MolecularCell. We hope this will be a useful resource for the community. @HailingShi @nemo08061 @WangXiaoLab

[good papers @paperperday]

An expanded molecular and systems toolbox for imaging, mapping, and controlling local translation

"RNA-centric and Protein-centric techniques for mapping of local translation"
https://t.co/lj4k8Pe1yt

[Chem @Chem_CP]

Online now: A skeletally diverse library of bioactive natural-product-like compounds enabled by late-stage P450-catalyzed oxyfunctionalization https://t.co/WaI1K3zrOH

[bryan dickinson @chembioBryan]

Check out our most recent work developing new strategies that leverage massive mRNA-displayed macrocyclic peptide libraries for covalent ligand discovery!

Congrats @LanT_763 and thanks for @mbogyo and Scott Snyder for collaboration!

https://t.co/rzBeQG4iKA

[Cholpisit Ice Kiattisewee @theicechol]

I haven't posted about politics for so long but this news makes my home country much more unpleasant to live in.

Imagine living in a state where the political parties, that won the election, keep getting dissolved/disbanded throughout your lifetime...

https://t.co/Kx3yR0jmU4

[Science Magazine @ScienceMagazine]

Brazilian sharpnose sharks have tested positive for cocaine near Rio de Janeiro. https://t.co/rO8vR7dyKo @NewsfromScience

[Kanokpol Aphicho @aphicho]

Another great example https://t.co/yPxJ5t3jJ4

[Kanokpol Aphicho @aphicho]

I've been thinking about prosthetic covalent linkage for capturing transient PPIs. This is beautifully done.

[Kanokpol Aphicho @aphicho]

I've been thinking about prosthetic covalent linkage for capturing transient PPIs. This is beautifully done.

[Liron Bar-Peled @LironBarPeled]

https://t.co/lgiGZaZJFr. Building on foundational work in the fields of molecular glues and covalent drug discovery including Ben Cravatt, @DanNomura , @SchreiberStuart , Nat Gray, @jaybradner (to name a few).

[Zhi lindsey Lin @Zhi_Lindsey_Lin]

Thrilled to share our MultiMap paper is now published online on Science. @ScienceMagazine With @realJimWells, we present a multiscale photocatalytic proximity labeling platform for interactome profiling. https://t.co/sEguPjaJdx

[Kanokpol Aphicho @aphicho]

Reminded me of this cool story of not-so-bystander Zn ion in this E2 campaign https://t.co/rB727H6yoY

[Bob the Grumpy Med Chemist @med_chemist]

Wonderful little paper here with many useful warnings inside:
https://t.co/xvIFI0eDEi
Practical notes:
-Do fresh resynthesis (orthogonal route a +)
-Test potentially interfering salts+compounds in assay
-Lots of things bind and give Xray structures at mM

More warnings below...

[bryan dickinson @chembioBryan]

Happy to share our newest work on developing novel biosensors for detecting calprotectin levels in patient samples:

https://t.co/dbhviwA72d