Today we published at @cellhostmicrobe the results of a Phase 1 study of @vedantabio‘s lead candidate VE303 (for C. difficile infection), with a focus one studying pharmacokinetics (PK) and pharmacodynamics (PD) of this defined bacterial consortium. https://t.co/yRu8RQ2Hps🧵 /1
Cutibacterium acnes evolution: One pore at a time. @LFlowers_A @specific_ames @aayushi_uberoi examine @arolynconwill@conTaminatedsci work showing #skin surface harbors multiple C. acnes lineages, but individual pores are dominated by an individual lineage https://t.co/pwRq4SXWBg
Anatomy promotes neutral coexistence of strains in human skin #microbiome: @arolynconwill@conTaminatedsci show #skin pores spatially segregate C. acnes genotypes via neutral bottlenecking, thereby reducing competition &promoting coexistence among lineages https://t.co/aon9hZeWXe
Hi #ScienceTwitter! @zgitai1 and I are so excited to share our recent preprint with everyone!
In this paper, we used a combination of imaging, sequencing, and culturing, and discovered that the skin surface is colonized by surprisingly few viable bacteria.
Important work from @BacteriaHunter : "the skin surface is colonized by far few viable bacteria than would be predicted by its levels of bacterial DNA. Instead, viable skin-associated bacteria are primarily present in hair follicles and other cutaneous invaginations."
We are hiring! We offer a fully-funded postdoc position at the interface of ancient metagenomics and palaeopathology to uncover the emergence of microbial pathogens. Join our young and fun lab @mpiib_berlin in Berlin. Please help spread the word. https://t.co/7RkVCKdb0j
First preprint from my postdoc with @contaminatedsci!
In summary, population bottlenecks in your skin pores help maintain microbial diversity on your face.
Read below to find out more...
Why do multiple strains of the same species coexist in a microbiome?
For C. acnes, we find that skin pores play a surprising - and genotype agnostic - role in maintaining diversity.
🧵Delighted to share our latest preprint, led by @arolynconwill.
https://t.co/PDWKPIS33m
Excited to share how a “Microfluidic Panflute” reveals scale-dependence in bacterial colonization success, stability and resilience. First preprint and major work by grad student @KaritaYuya with help from @limmerlab
Why do multiple strains of the same species coexist in a microbiome?
For C. acnes, we find that skin pores play a surprising - and genotype agnostic - role in maintaining diversity.
🧵Delighted to share our latest preprint, led by @arolynconwill.
https://t.co/PDWKPIS33m
Longer twitter thread coming soon. For now, please enjoy this first preprint from the Lieberman Lab at MIT -- and our great collaborators-- and send any feedback/critiques you have our way!
🦠 🦠 🦠 Registration is now OPEN for our symposium 🦠 🦠 🦠 Our first 75 registrants will receive an exclusive club shirt featuring our favorite poop mascot (shipped within US)!
https://t.co/aIGDYDsvpH
Follow us to hear more about our awesome speaker lineup!