Great effort from the team on this study published in Cell today! Hard work pays off - well done everyone 👏🏻
Exciting science - discovering new T-cell receptors for cancer immunotherapies 🔬
#cancerimmunotherpies#cellscience#tcells
https://t.co/6zzD0IVUeP
Authored by Andrew G. Soerens et al, we show that #Tcells are capable of proliferating in response to iterative stimulation for over 10yrs! And produce enough progeny to occupy a volume 30,000x the Earth's volume! @Nature https://t.co/jPfmX2Ilrq
Result of a great collaboration between our group, @MiriamMerad, many others at Sinai and also Regeneron. The data is really beautiful and provides more understanding about the re-priming conditions for effective PD1 therapy.
My #Tweetorial on our recent work on the roles of T cell intrinsic #androgen receptor (AR) in CD8+ T cell exhaustion in cancer.
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Link to the original paper:
https://t.co/PkDO28uXCc
Press release for the public:
https://t.co/Fqnxfdl4jQ
Interested in single cell genomics but need help getting started? Check out my lab's Single Cell Genomics Day on March 4. Talks will feature recent exciting computational and experimental advances and will be livestreamed at https://t.co/zG98gkckMU. Please RT/spread the word!
Exhausted T cells and Tumor macrophages are symbiotic. @KellyKersten8 shows TAM induce a unique synapse, priming Tex for exhaustion w/o inducing proliferation. Meanwhile Tex attract and promote TAMs. ZipSeq shows this is spatially localized in tumors. https://tinyurl/TAMTex
BREAKING NEWS:
The 2021 #NobelPrize in Physiology or Medicine has been awarded jointly to David Julius and Ardem Patapoutian “for their discoveries of receptors for temperature and touch.”
Using an allele-conditioning strategy, @lawrenceandrews generate mice that temporally restrict Cre activity and gene deletion to CD4+ T conventional cells, while sparing CD4+ T regulatory cells. @Vignali_Lab
https://t.co/ok9I0hvPTO
We are so excited to finally share our new study reporting the evolution of cross-resistance between targeted therapy and immunotherapy, published today @NatureCancer. Highlights in the 🧵👇 Free access here https://t.co/TasdMFh7gR 1/25