astolyarova

PhD in evolutionary biology @ Bazykin lab at Skoltech, Moscow

[astolyarova @avstolyarova]

Our paper on positive epistasis and balancing selection now out in @eLife! See how an extremely polymorphic population of a wood decay fungus can navigate rugged fitness landscapes (thanks @VBurskaia for the beautiful illustration) https://t.co/RiJhZgreEy

[Ruslan Soldatov @_ruslansoldatov]

Very excited to share that I recently started my lab in @CompOncMSK at @MSKCancerCenter!

Looking for postdocs and graduate students interested in cell fate decisions/cancer evolution/computational single-cell genomics. Come join us in NYC!
Spread the word & please #RT. Thanks!

[astolyarova @avstolyarova]

uncovering done! great conference and cool virtual lecture hall, looking forward to next #SMBEeverywhere symposia

[SMBEmeetings @SMBEmeetings]

#AnastasiaStolyarova uncovering mutation spectrum bias in cancer by looking at driver genes and the #DFE, using empirical data and simulations
#SMBEeverywhere
@OfficialSMBE

[astolyarova @avstolyarova]

the thread https://t.co/U6qnTAg1w4

[astolyarova @avstolyarova]

Our study on within-population epistasis is out as a preprint today! https://t.co/F6nJJtQBVC
Epistasis shapes variation within a hyperpolymorphic fungus S. commune - with ~20% of neutral sites differing between any two sampled genomes. We detect it by linkage disequilibrium (1/4)

[astolyarova @avstolyarova]

Our paper on positive epistasis and balancing selection now out in @eLife! See how an extremely polymorphic population of a wood decay fungus can navigate rugged fitness landscapes (thanks @VBurskaia for the beautiful illustration) https://t.co/RiJhZgreEy

[astolyarova @avstolyarova]

@tjournal Не заразились от одного человека (это как вообще), а заразились потомками вируса, завезённого одним человеком

[astolyarova @avstolyarova]

Epistatic effects are particularly pronounced in short (<1kb!) but abundant haploblocks, which we suppose are maintained by balancing selection. (4/4)
Thanks to @GBazykin and Alexey Kondrashov for the supervision and discussions!

[astolyarova @avstolyarova]

Our study on within-population epistasis is out as a preprint today! https://t.co/F6nJJtQBVC
Epistasis shapes variation within a hyperpolymorphic fungus S. commune - with ~20% of neutral sites differing between any two sampled genomes. We detect it by linkage disequilibrium (1/4)

[astolyarova @avstolyarova]

Epistatic constraints are preserved in two diverged S. commune populations, so that LD values between pairs of shared alleles in two populations are correlated (3/4)

[Ruslan Soldatov @_ruslansoldatov]

It is well known that mutation rate varies along the genome. Together with @seplyarskiy we employed this variability to reconstruct portrait of major mutational processes in the human germ line. Thanks to Shamil Sunyaev, his lab members and @KharchenkoLab!
https://t.co/mskHmmk5ch

[Matthew Hahn @3rdreviewer]

I went down a cool scientific rabbit hole this morning, and thought others might find it interesting. It's about "phantom epistasis"--basically the statistical appearance of epistasis when everything is additive.

1/x

[Georgii Bazykin @GBazykin]

Wide-spread sex in famously asexual bdelloid rotifers (previously known as “the evolutionary scandal” because they allegedly couldn’t do sex). Still unclear how they do it, but the fact is now inescapable. Congratulations Olga! https://t.co/BGxX2fI5GH

[Valentina Burskaia @VBurskaia]

Should start with something. Painted these ringtail possums last winter. They look quite surprised.

[Bioinfo Googling (TM) @GooglingBioinfo]

I declare that my paper has been accepted now we can’t let any more reviewers steal our victory

[Matthew Hahn @3rdreviewer]

I made this (hopefully) helpful graphic on the different models to explain the fixation of slightly deleterious alleles.

Comments on clarity/accuracy?

[astolyarova @avstolyarova]

Getting ready for my within-population epistasis talk at #EMBLEvoEco! Very excited to hear the talks and see the posters

[Georgii Bazykin @GBazykin]

Finally out, as GBE cover: https://t.co/JJA9olVRuF

[Bioinfo Googling (TM) @GooglingBioinfo]

does linkage disequilibrium mean I can ignore everything we know another basic statistics

[Richard Behringer @rrbehringer]

1st cloned Przewalski’s horse born Aug 6. Nucleus from stallion cells cryopreserved ~40 yrs ago in San Diego Zoo Global Frozen Zoo® introduced into oocyte from domestic horse. @SSRepro @___SDB___ @the_Node @GeneticsGSA @sdzglobal https://t.co/rXlwsA1RHN