Aydogan Lab

We study principles of biological time control with a focus on the emerging concept of autonomous clocks.

Columbia University & HHMI

[Aydogan Lab @AydoganLab]

EXCITED to unroll this 🧵 on our new story on the metabolic licensing of animal development... How did we even get here..?

https://t.co/Z5mhTtLGde

Early embryo is thought of a pre-set machine that's set to go once it's fertilized - check out this gorgeous 📽️from Phil Keller!

[Aydogan Lab @AydoganLab]

@AMartinezArias Ah.. I see the nuance. Thanks for clarifying, Alfonso!

[Aydogan Lab @AydoganLab]

Isn't that true for any observation in science? 🧐

[Alfonso Martinez Arias @AMartinezArias]

This is an interesting observation with potential practical implications but, as long as there is no independent confirmation/reproduction it will remain just an anecdote.

[Eric Betzig @Eric_Betzig]

Absolutely. Every major idea I’ve had, and nearly every solution to a roadblock when executing those ideas in the lab, has arisen from long periods of solitude. It’s no mystery - the process of discovery involves winnowing through an infinite thicket of possibilities to find the answer, and any interruption to this reverie crashes the whole edifice of thought to the ground.

[HHMI @hhmi_science]

Rising undergrad junior or senior? Last chance to apply! Applications close TOMORROW, Dec. 22, 11:59pm EST.

Our 9-week summer research experience includes hands-on lab work, a generous stipend, & mentorship from some of the nation’s top scientists. Learn more & apply at https://t.co/dhQol9H28o.

[Aydogan Lab @AydoganLab]

👏👏

[The Nobel Prize @NobelPrize]

"Don't follow the existing research."

To truly make an impact, this year's chemistry laureate Susumu Kitagawa advises young scientists to think independently and follow their own path. Kitagawa was awarded the Nobel Prize for his work developing MOFs, porous materials which are able to store and release small molecules, in an amazing array of uses.

Learn more: https://t.co/pQvG7xYEJv

[Ruben Gonzalez @rubenlgonzalez]

The Gonzalez Lab at Columbia University is seeking a scientific leader!

Join us in a Research Scientist position, driving single-molecule, structural, and biochemical studies of translation, translational control, and other RNA-based processes.

Apply: https://t.co/84JwVnrhS1

[Iva Tolić @Toliclab]

Two back-to-back stories on mitosis led by my incredible postdoc @KrunoVuk at @institutrb, in which we challenge the gliding model of CENP-E-driven chromosome congression! Today in @NatureComms https://t.co/oUwguXWRUN
https://t.co/bCnHSvthbQ

[Cell Biology UTSW @CellUtsw]

We are accepting applications for 2 tenure track faculty positions at UTSW in the Department of Cell Biology! Apply before October 31st!

[Aydogan Lab @AydoganLab]

If you’re around in NYC, and studying microtubules or mitosis, this one is not to be missed!

[Aydogan Lab @AydoganLab]

@Alexis_Lomakin Congrats, Alexis and team!!

[Aydogan Lab @AydoganLab]

@gparlakgul @BerkeleyMetBio @UCBerkeley Sincere congratulations Gunes! So well deserved 🥳

[Ekaterina Korotkevich @eykorotkevich]

Excited to share our new paper! mtDNA mutations contribute to mitochondrial disease and aging only if they rise in abundance. We show that deleterious mutations reach high abundance by hitchhiking on genomes that have a replicative advantage
https://t.co/Pqahch5qe5

[Tychele Turner @tycheleturner]

Here’s to all my colleagues rocking bowties! Happy #BowtieDay! Shoutout to @SandyBoynton for the image. #Style #WorkLife

[Aydogan Lab @AydoganLab]

If you're finishing PhD soon and thinking of postdocs, see below!

Especially if you're keen on combining biochemistry, imaging and cell biology, we are onto some exciting findings on molecules and mechanisms underlying a cytoplasmic division cycle autonomously of CDKs!!

[Aydogan Lab @AydoganLab]

#Postdoc opportunity at Columbia U. in New York!

We are interested in candidates from biochemistry backgr. & excited about fractionation, purification and reconstitution to study autonomous clocks in the cell cycle, in colab. w/ @Aydinlab at NYU!

https://t.co/bNBHILsmJr

[Aydogan Lab @AydoganLab]

#Postdoc opportunity at Columbia U. in New York!

We are interested in candidates from biochemistry backgr. & excited about fractionation, purification and reconstitution to study autonomous clocks in the cell cycle, in colab. w/ @Aydinlab at NYU!

https://t.co/bNBHILsmJr

[Gizem Efe @GizemEfePhD]

🚨Thrilled to announce I will be presenting our work at the Cold Spring Harbor Genome Engineering: CRISPR Frontiers Meeting (@CSHL) Aug 12–16! 🧬✨

We're combining cutting-edge in vivo CRISPR strategies with cancer research to uncover how mutant p53 drives metastasis—mutation by mutation.

From high-throughput in vivo CRISPR knockout screens to precision base & prime editing, this project dissects tumor evolution at an unprecedented resolution. Our findings underscore the emerging potential of allele-specific treatments in precision oncology.

Let’s talk CRISPR, cancer, and innovation! #cshlcrispr25 #CRISPR #p53 #cancerresearch #metastasis #CancerGenomics @cshlmeetings @ColumbiaMed

[Tanentzapf Lab @TanentzapfLab]

I think a good rule of thumb is to spend at least as much time thinking about your data as you did obtaining it. It's common for people to spend a lot less time thinking than doing which gives rise to all kinds of problems.

[Elif Nur Firat-Karalar @CytoLabKoc]

I'm pleased to share this work now published in @PLOSBiology! Since our preprint, we've uncovered exciting new links connecting CCDC66 to actin, vesicular trafficking, and Wnt signaling, and revealed how these contribute to CCDC66's ciliary functions. See link below!

[Prof. Nikolai Slavov @slavov_n]

In case this is not obvious:

Expecting to understand and predict human biology based solely on modelling nucleic acids is naive.

It’s unrealistic.

[Leslie Vosshall PhD @leslievosshall]

Join the #VosshallLab as a postdoctoral scientist! Fully funded position in New York City @RockefellerUniv
https://t.co/XfhsO4j5h0