🎉We are delighted to share the winners of JP-sponsored student prizes (MSc and PhD) which were presented at the 2025 Ontario Exercise Physiology (OEP) Conference!
Congratulations to MSc awardee Brooke Morris & PhD Awardee Ryan Bevington. 👏
Women experience faster, earlier muscle decline with age.
New data from @steven_obryan and co. in women aged 18–80 found the steepest declines begin in the 4th decade, around menopause.
Why sex-specific research matters - as does tailored strategies to help women age stronger.
1/10 Excited to write this thread summarizing our new paper in @NatMetabolism, which identifies a potentially critical part of the signaling pathway that drives skeletal muscle growth in response to resistance exercise!
Free link https://t.co/JWca6dVU2a
#Myotwitter@NIH_NIAMS
When is a change in mitochondrial bioenergetics reflective of 'mitochondrial dysfunction' vs 'intentional reprogramming'?
Here we present traditional vs alternative interpretations of mitochondrial responses to muscle disuse.
https://t.co/mvtMxAGnp3
It was a privilege listening to the latest developments in the muscle physiology world from a range of phenomenal scientists @UFMyology ‘s ASMB
To top it off, I got to speak on some data I collected for my MSc project in a 2MIN Blitz talk and more in depth at the poster sessions
This overview of reviews suggests that the literature overall suggests that physical activity containing an aspect of resistance training, for a minimum of twice per week, is beneficial at reversing frailty status and preventing frailty progression.
There is no one more important to us at the Advances in Muscle Biology Conference than the trainees. Today they have delivered outstanding talks and presented incredible posters. Some of the “data blitzers”:
Obesity isn’t just about eating less and moving more.
Our #FoodEnvironment has a profound impact on health. From accessibility to marketing, understanding these influences is key to tackling #obesity. 💪
This #WorldObesityDay, let’s talk about the bigger picture. #WOD2025
We are so concerned with the "optimal" type/intensity/duration of exercise that we forget that the biggest public health benefit is from helping those least active to do a bit more.
“Mitochondrial dysfunction” is a misleading misnomer
Mitochondria have many functions and behaviors, and many ways to be dysfunctional
https://t.co/e6GXDadLT6
Our 3rd new manuscript this week: @DelfinisLuca found a mitochondrial-targeted compound partially prevents muscle weakness without preventing atrophy in ovarian cancer. This opens a new direction for therapies targeting muscle ‘quality’. https://t.co/tavvytrjCh
We just uploaded our next preprint on cancer-cachexia.
Shahrzad Khajehzadehshoushtar discovered 'the mitochondrial-targeted antioxidant SkQ1 prevents mitochondrial-linked apoptosis but not necroptosis or skeletal muscle atrophy in ovarian cancer'
...why is apoptosis active?
NEW preprint: Shivam Gandhi in our lab shows cardiac fibrosis in a young mouse model of Duchenne muscular dystrophy occurs in 2 of 4 chambers. Why not all 4?
Remarkably, this fibrosis is completely prevented by a novel adiponectin receptor agonist ALY688.
https://t.co/GUNMqv8XSm
Marleen A. van Baak & Edwin C. M. Mariman review #obesity-induced and weight-loss-induced physiological factors affecting weight regain (£) https://t.co/Syna8Bx3Y4
Does the menstrual cycle influence the determinants of endurance performance?
Our recent #FENDURA publication was published in print this month on @MSSEonline. Here is a infographic to help translate some of our findings.
🔗: https://t.co/TSIhYiVrpT
It’s never too late to benefit from exercise.
Like this world champion powerlifter - who started lifting at age 63.
At age 71 she now has greater (vs. aged-matched controls):
➡️Quadriceps size (+37%)
➡️Handgrip strength (+33%)
➡️Leg press strength (+36%)
➡️Skeletal muscle index (+33%)
➡️Type II muscle fibre size (+46%)
Nothing like resistance training to buck the trend with ageing.
https://t.co/icHUA7M7ua
Congrats to Shahrzad Khajehzadehshoushtar @SharShoush for an outstanding MSc defence! Shar is nominated for a thesis prize for a carefully crafted document, voluminous work, + high-level discussion
Watch for Shar's publication on mitochondrial therapy in ovarian cancer cachexia