Antonino Cassotta

My lab dissects the human T cell repertoire targeting tumor and self-antigens. Learning from nature, we aim to engineer improved immunotherapies.

[Science Magazine @ScienceMagazine]

Researchers in @scisignal discovered a signaling mechanism that prevents T helper 17 cells from adopting pathogenic states linked to autoimmunity, potentially informing future efforts to treat autoimmune diseases such as multiple sclerosis.

Learn more on #WorldMSDay: https://t.co/1OhYNgsoSa

[Antonino Cassotta @cassottalab]

Join our lab at Karolinska Institutet in beautiful Stockholm 🇸🇪!
We are recruiting an enthusiastic postdoc to dissect tumor-reactive T cells in cancer patients and help advance immunotherapies, collaborating closely with clinical researchers.
Apply here: https://t.co/5xP1RPZgi2

[Journal of Experimental Medicine @JExpMed]

Bianchi et al find that the FCRL3 receptor is expressed upon repetitive activation of human memory T lymphocytes & limits their responses via inhibitory pathways. This study identifies FCRL3 as a regulator of highly differentiated memory T cells in humans https://t.co/9Mqs3xWivc

[The Nobel Prize @NobelPrize]

This year’s medicine laureate Shimon Sakaguchi discovered a new class of T cells.

Sakaguchi was swimming against the tide in 1995, when he made a key discovery. At the time, many researchers were convinced that immune tolerance only developed due to potentially harmful immune cells being eliminated in the thymus, through a process called central tolerance.

Sakaguchi showed that the immune system is more complex and discovered a previously unknown class of immune cells, which protect the body from autoimmune diseases.

#NobelPrize

[Science Signaling @scisignal]

Researchers have discovered a signaling mechanism that prevents T helper 17 cells from adopting pathogenic states linked to #autoimmunity, potentially informing future efforts to treat autoimmune diseases such as multiple sclerosis. @BRFAA_IIBEAA https://t.co/dUgcIhO3Zs

[Science Magazine @ScienceMagazine]

Researchers have discovered a signaling mechanism that prevents T helper 17 cells from adopting pathogenic states linked to #autoimmunity, potentially informing future efforts to treat autoimmune diseases such as multiple sclerosis. @SciSignal https://t.co/cGYBFxB3ow

[Waggoner Lab @LabWaggoner]

Epigenetic reprogramming that promotes oxidative metabolism suppresses TH17 cell pathogenicity @scisignal 🇬🇷🇮🇪🇦🇹🇫🇷🇨🇭
https://t.co/yh4yY4CePu

[Antonino Cassotta @cassottalab]

@OdedRechavi Very cool! Is it possible to run it locally to maintain confidentiality over partially formed ideas?

[Waggoner Lab @LabWaggoner]

Polyfunctional, cytotoxic, TCR-biased CD4 T cells, targeting NY-ESO-1, offer great promise for adoptive cell transfer in patients @ScienceAdvances
https://t.co/VJcDKouFU7

[Antonino Cassotta @cassottalab]

The AI Revolution Is Underhyped | Eric Schmidt | TED https://t.co/U98ZX8f9wB via @YouTube

[Klebanoff_Lab @KlebanoffLab]

🚨Today in @CellCellPress, we show that RNA splicing factor mutations in myeloid cancers generate splicing-derived public neoantigens targetable by #TCR tx. Amazing collaboration co-led by @AbdelWahablab, @bradleybio, and @KlebanoffLab. #Tcellpower
https://t.co/5fycZiLEWg

[Antonino Cassotta @cassottalab]

Learning the language of T cell receptors through large-scale screening: Cancer Cell https://t.co/qMZCymwjPP

[Waggoner Lab @LabWaggoner]

Terminal differentiation and persistence of effector regulatory T cells essential for preventing intestinal inflammation @NatImmunol
https://t.co/eV6Gl0mK5Q

[Pilar Martín Fernández @PilarMartinFern]

Our latest review in JCI is out - T cells in cardiac health and disease https://t.co/63AIPkFbJL @CNIC_CARDIO @CIBER_CV

[Waggoner Lab @LabWaggoner]

Elucidating the role of autoreactive T cells and B cells in autoimmune hepatitis
@jclinicalinvest
https://t.co/Y4d09F4D82
https://t.co/hyW83TVqTr

[Mustafa Ghanizada @MGhanizada_]

Excited to share our paper in @NatImmunol
Congrats to Xin (Co-first) and all the other authors (@VMallajosyula, @KaranRKathuria and more). Special thanks to Prof Mark Davis for all his mentorship and guidance!
@UCPH_health @StanfordMed @lundbeckfonden
https://t.co/7ZpmTzvTrq

[Jens Puschhof @JensPuschhof]

Our new #organoid #organchip #coculture review. Congrats @_KamilMoskal, @Yeseul700lee, Luisa Siegert, Nimisha Khurana from @EMIL_DKFZ @DKFZ!
Cool experience connecting the dots between in organotypic models and microbiome with @HansClevers and @EranElinav!

[Nature Biotechnology @NatureBiotech]

A cure for HIV? TCR agents seek to wipe out viral reservoirs https://t.co/VrFaRg5k6H

[Itai Yanai @ItaiYanai]

Top 4 misconceptions about science
1. It fills knowledge-gaps (discoveries are unknown unknowns)
2. It proceeds along a straightforward path (discoveries are not predictable)
3. It looks for answers (new questions are crucial)
4. It is only rational (requires night science leaps)

[Antonino Cassotta @cassottalab]

Congrats for this beautiful work!

[Vamsee_Mallajosyula @VMallajosyula]

Thrilled to share our latest work on broadening T cell help for developing better flu vaccines @ScienceMagazine @sarah_h_ross
Grateful for Mark Davis’s invaluable mentorship @StanfordMed @stanfordimmuno https://t.co/qeY0bQhXyU 1/n