Callie Fredlender

PhD👩🏼‍🔬 | Neuro 🧠 & Drug Discovery 💊

[Nature Chemical Biology @nchembio]

A new paper from @TheAlbrecht_Lab and @LJSeabrook developed a targeted protein degradation platform, MrTAC, that enables arginine methylation-driven degradation of intracellular proteins in lysosomes https://t.co/p8tGSsY0Ip

[Oded Rechavi @OdedRechavi]

Being a scientist is amazing - one moment you're having a brilliant idea and BOOM! 10 years and 1 million $ later it's published in a journal

[The Nobel Prize @NobelPrize]

Did you know that the properties of an element can change when shrunk to the nanoscale?

[Callie Fredlender @CFredlender]

@SpitaleLab Happy birthday, Rob!! 🚀🚀🚀

[Vertex Pharmaceuticals @VertexPharma]

We are pleased to announce that our biologics license applications (BLA) for our potential treatment for sickle cell disease (SCD) & beta thalassemia have been accepted by the FDA & our application for SCD has been granted priority review. Learn more: https://t.co/a86F0s0Qi6

[Alexander Huth @alex_ander]

In the latest paper from my lab, @jerryptang showed that we can decode language that a person is hearing (or even just thinking) from fMRI responses. https://t.co/GUCDtiaXlR

[Dr Meming @Dr_Meming]

Me: Yeah I can do that experiment

Also me:

[Vertex Pharmaceuticals @VertexPharma]

We are pleased to announce that we’ve completed the submission of our Biologics License Applications (BLAs) to the U.S. FDA for our potential treatment for sickle cell disease and beta thalassemia. Learn more: https://t.co/Iq3r8E4zUH

[Brian Paegel @BrianDNA]

My third @UCIrvine graduate student, the incomparable Amanda Nguyen, advanced to Ph.D. candidacy today! BOBA beads coming soon! Also, note the tiara. #queen @TheAlbrecht_Lab @UCI_SPPS

[Journal of Experimental Medicine @JExpMed]

Engineering an inhibitor-resistant human CSF1R variant for #microglia replacement. A new study from Jean Paul Chadarevian @JPChadarevian, Sonia I. Lombroso @Sonia_Lombroso, Mathew Blurton-Jones @BlurtonJonesLab F. Chris Bennett @FChrisBennett & colleagues: https://t.co/f3KFXW6oPK

[Dan Nomura @DanNomura]

Paper out of Genentech on Targeted protein degradation via direct 26S proteasome recruitment | Nature Chemical Biology https://t.co/73VWD5OPci

[Jorge Almagro @almagro_jorge]

Merry christmas from my organoids! 🎄

[Tyler Sloan @quorumetrix]

I’ve made this video as an intuition pump for the density of #synapses in the #brain. This volume ~ grain of sand, has >3.2 million synapses (orange cubes). Peeling them away leaves only inputs on 2 #neurons. Zooming in, we see the synapses localized to the dendritic spines.
#b3d

[Callie Fredlender @CFredlender]

@TheAlbrecht_Lab @carointhelab @UCI_SPPS @UCI_CRI @UCIChemistry @LJSeabrook KILLLEDDD ITTTT💥

[Bruce Levine, Ph.D. 🇺🇦🥼🔬🧬🧪💉 @BLLPHD]

The Age of Cell Therapy is here. Emily Whitehead shows you why. 🙏

[Maddie Lee, PhD @m_janelee]

Got my Halloween costume all picked out :)

[Dan Nomura @DanNomura]

From ⁦@SchreiberStuart⁩ and ⁦@NovartisScience⁩: DNA-encoded library (DEL)-enabled discovery of proximity-inducing small molecules | bioRxiv https://t.co/i14C5EZagb

[Sam Westwood @westwoodsam1]

When you have no data to present at the lab meeting
@AcademicChatter @AcademicsSay

[Robert Spitale @SpitaleLab]

Years in the making. Excited to announce the launch of the UCI Center for Neurotherapeutics. Drug discovery ENGINE aimed at uncovering new medicines to treat neurodegenerative diseases. @UCI_SPPS @UCIrvine

https://t.co/F8Pys5htOB