OASIZ-301 (dazodalibep, Sjögren phase 3): ESSDAI improved significantly vs placebo at week 48.
Difference −1.8 and −1.4 depending on regimen.
Dryness and systemic activity are two different problems. The patient plan has to cover both.
https://t.co/o8fvKJ6lg3
Thrilled to share new work from our experimental biology lab at @AnthropicAI. Led by world-class biochemist Januka Athukoralage, we built a rapid method for the isolation and structural characterization of vaults. It turns out these massive structures are not just found in eukaryotic cells, but also in prokaryotes and even phages. We solve the structure of one of these phage vaults, and then demonstrate we can engineer additional repeats into the wall to make it bigger.
One thing I can't get over about these vaults. They seem to be widespread across life - we assembled them from 8 different bacteria and bacteriophages. But they are just so massive - bigger than ribosomes, AAV, and even some phage capsids. Why devote so much energy to making these huge complexes? They have to be doing something useful - I hope that's the question that gets answered next.
Amazing collaboration with @PeterHYoon, @amirshanehsaz, @eric_kabrams, and @mgdurrant! Grateful to our team for making Claude an amazing labmate and to Anthropic for supporting this type of work on fundamental biology.
Natural mysteries abound - let's get to solving them!
Links here:
Blog: https://t.co/O6VtahFIvo
Technical report: https://t.co/erue23SFWl
We’re sharing how our biology research team worked with Claude to map the first 3D structure of a vault particle from bacterial life.
Vault particles are a longstanding mystery. They are barrel-shaped objects, among the largest protein structures found in our cells. They were first discovered by Leonard Rome and Nancy Kedersha in 1986, but their function remains unknown.
With Claude, we’ve found results that might bring us closer to solving that mystery.
Until now, vaults were only known in the cells of complex things like animals and plants. We have shown that similar proteins from bacteria (and the viruses that infect them) can also assemble into vaults. Finding the structures in these simpler forms of life may make it easier to investigate their function in our own cells.
For our life sciences team, the project was also a demonstration of the potential (and the limitations) of using AI to accelerate science.
In our full piece, we discuss how Claude was able to dramatically speed up some stages—manually determining the vault particle’s structure would have taken weeks to months of painstaking work, but here it took days. We also discuss how Claude made some simple mistakes along the way, and how we collaborated with our machine learning researchers to address them.
Read more: https://t.co/KowVVCSPp8
The Hermes Agent Plugin Hackathon starts now!
It runs for 7 days, with $20,000 in cash prizes and more.
Plugins are the most powerful way to extend Hermes Agent, and we want this hackathon to show what they can do. A plugin can change anything from the model Hermes runs on, where it stores its memory, where it runs commands, which messaging apps it works in and what Hermes Desktop shows. Plugins in the marketplace already let Hermes do things like control a phone or turn a photo into a printable 3D model.
Every kind of plugin is eligible, so build whatever functionality you want Hermes to have. We'll list accepted entries in the new Hermes Marketplace, where every Hermes user can install them.
Prizes
1st: $10,000 + neon sign + merch + $1,000 creds
2nd: $5,000 + neon sign + merch + $1,000 creds
3rd: $2,500 + neon sign + merch + $1,000 creds
4th: $1,500 + merch + $500 creds
5th: $1,000 + merch + $500 creds
Runners up (x5): merch + $250 creds
Submissions are due 5PM EST on Nov 11th. To enter:
1. Open a pull request that adds your plugin to the Hermes plugin catalog: https://t.co/mXvYukJ0mZ
2. Post a demo video on X and tag @NousResearch
3. Submit both links through the form: https://t.co/jlduHHW3dr
Your entry is the plugin itself. Judges score it on usefulness, reliability, polish and creativity, and they favor plugins that do more than a prompt or a skill could. Keep the demo under 90 seconds and show the plugin working.
The developer guide shows how to build and test a plugin: https://t.co/FVGjSgjNoV
When submissions close, we'll open a thread for every entry in the Nous Research Discord, so you can browse all the plugins and talk to the people who built them.
You can submit the form as soon as your pull request is open. The catalog checks run once a maintainer starts them, and we review entries every few days.
If you have any questions stop by the Nous Research Discord: https://t.co/qxek9haYeb
GLHF!
🚨UPDATE: Crédit Mutuel Arkéa FINALLY confirms cyberattack behind suspected $133 MILLION+ theft.
The French bank says fraudulent transfers from its account were converted into crypto through specialized platforms.
ZachXBT estimates losses exceed $133 million; the bank acknowledged the scale but has not confirmed a final figure.
The incident has been contained and some stolen funds blocked. Customer assets remain unaffected, though certain transfers were delayed says the bank.
Arkéa also says the losses do not threaten its financial strength. ZachXBT warns the total could rise as further transactions are identified.
🚨 BREAKING: Hackers are hitting the world's money system in 7 places at the same time.
This is what Covid looked like in week 1. A few banks. A few apps. Nobody called it a crisis.
1/ France: more than €118 million (about $133 million) was pulled out of Crédit Mutuel Arkéa over several days and turned into crypto. Today its app was down and EVERY transfer was blocked. The bank says customers lose nothing.
2/ Belgium: on October 28, the federal finance ministry said a cyberattack hit it. The online tax portal was SHUT and tax deadlines will be pushed back.
3/ Eurozone: on October 22, the European Central Bank, the bank behind the euro, confirmed that attackers planted malware on one of its websites.
4/ South Korea: at least 9 banks targeted since late September by an attacker using an AI hacking agent. At Shinhan Bank alone, about 25,000 customers had their names, phone numbers, incomes and loan limits exposed.
5/ Japan: hackers broke into GMO Internet and demanded $50 million in crypto. The prime minister promised an emergency anti-cyberattack package.
6/ At least 14 countries: China-linked hackers used AI agents to attack 200+ organisations in just 11 days. Finance was on the target list.
7/ Crypto: more than $6 billion drained from Binance hot wallets on 11 blockchains on October 29, most of it in about 30 minutes. The FBI says North Korea did it.
Now zoom out.
Hackers now send AI agents to do the work. The French money left over several days before the bank confirmed anything. Fake IDs passed the crypto exchanges' checks. About $63 million in stablecoins became 27,553 Ether in 4 hours. Part of it vanished into Monero, a coin built to hide who sends and who receives.
Covid locked the streets. This time the lock is on the bank app, and €118 million is already gone. Nobody is calling this a crisis yet. But central bankers already plan for the day the hackers get in.
The G7 agreed to run drills that simulate AI attacks on banks. The ECB gave eurozone banks until October 31 to hand in AI cyber defence plans. And last month the IMF chief warned we may end up with "lots of people with shoeboxes under their beds."
We confirm every attack on banks and exchanges before we post it. Follow for the next confirmed case, and share this with anyone whose salary lands in a bank account.
🚨ROBINHOOD AND ARBITRUM LAUNCH $1.8M GRANTS FOR ROBINHOOD CHAIN BUILDERS!
@RobinhoodCrypto is teaming up with @arbitrum to back developers on Robinhood Chain through Open House, with $1.8M in total grants for projects that launch on the chain.
The next phase is Cohort 2 of the Arbitrum Mentorship Program, a 12-week track that includes investor connections, a Demo Day pitch, and $100K grants.
Applications stay open until December 6.
🚨 ONE BANK FAILURE HAS NOW TURNED INTO A NATIONAL CRISIS IN PARAGUAY.
24 hours ago, the central bank shut down ueno bank, a bank used by 60% of the country's adults.
Now the damage is spreading.
• 13 mutual funds run by 5 different firms have frozen withdrawals because their money was invested in ueno
• Trading in all of ueno's bonds has been suspended
• $380M from the state pension fund is stuck, along with money from the state power company and the Itaipú dam
• 2 out of every 3 card payments at big stores ran through ueno, and Paraguay's main importers' association says retail is now "semi paralyzed"
Customers can only get back up to $1,700 for now, with no date given.
The political fallout is just as big.
The central bank chief, who used to run ueno, has resigned. President Peña cancelled a foreign trip to deal with the crisis, and authorities have ordered the arrest of 8 bank executives.
The anger has now reached the streets and Widespread protests are happening now.
The central bank says this is a one-off.
But in October, Paraguay's 14 private banks had already asked it to report on the solvency of other lenders.
🇵🇾 Chaos on the streets as Paraguay’s largest digital bank collapses
Nearly 3 million customers affected as the country faces a major political and financial crisis.
Paraguay’s Central Bank (BCP) seized Ueno Bank, the country's largest digital lender, after its solvency ratio collapsed to less than half the legal limit.
Central Bank President Carlos Carvallo resigned at the request of President Santiago Peña. Carvallo previously chaired the finance company that evolved into Ueno Bank, drawing heavy criticism over regulatory blind spots and conflicts of interest.
The Specialized Unit for Economic Crimes and Anti-Corruption ordered the detention of eight high-level executives and figures tied to the bank, including founder and majority shareholder Miguel Vázquez and Ueno Bank President Juan Manuel Gustale.
The intervention completely froze Ueno Bank’s digital app, credit cards, and transfer capabilities. This has locked out roughly 3 million users, an estimated 60% of Paraguay's adult population, leaving many with no immediate way to access their money.
The state health and pension fund (IPS) has an estimated $380 million in public retirement funds invested in Ueno Bank.
Angry citizens, savers, and pensioners flooded the streets of the capital and gathered outside closed branches, demanding their cash and chanting for political accountability.
🇵🇾 Chaos on the streets as Paraguay’s largest digital bank collapses
Nearly 3 million customers affected as the country faces a major political and financial crisis.
Paraguay’s Central Bank (BCP) seized Ueno Bank, the country's largest digital lender, after its solvency ratio collapsed to less than half the legal limit.
Central Bank President Carlos Carvallo resigned at the request of President Santiago Peña. Carvallo previously chaired the finance company that evolved into Ueno Bank, drawing heavy criticism over regulatory blind spots and conflicts of interest.
The Specialized Unit for Economic Crimes and Anti-Corruption ordered the detention of eight high-level executives and figures tied to the bank, including founder and majority shareholder Miguel Vázquez and Ueno Bank President Juan Manuel Gustale.
The intervention completely froze Ueno Bank’s digital app, credit cards, and transfer capabilities. This has locked out roughly 3 million users, an estimated 60% of Paraguay's adult population, leaving many with no immediate way to access their money.
The state health and pension fund (IPS) has an estimated $380 million in public retirement funds invested in Ueno Bank.
Angry citizens, savers, and pensioners flooded the streets of the capital and gathered outside closed branches, demanding their cash and chanting for political accountability.
1/5 Comento la lista de @OrlandoRPN con la evidencia de cada caso, porque no todos "dejaron de servir" por la misma razón: unos dañan, otros solo no mejoran desenlaces duros. Distinguirlo cambia qué se retira y qué se conserva.