Dave Rhee

Dad | Molecular Glues | Proteomics

[60 Minutes @60Minutes]

Harvard researcher Joan Brugge says her work has the potential to prevent breast cancer, but she was notified last spring that her federal funding was terminated. “It was just like a gut punch. My knees buckled, and I had to sit down,” she says.

[Katherine A Donovan @kdonovan1008]

🧩 New paper out in Nature Communications!

"Unveiling the hidden interactome of CRBN molecular glues"
Huge thanks to our incredible team and collaborators who made this possible!
📖 Read the full open-access article here: https://t.co/iuTyDM24Vs

[Cell Biology J-Club @cell_club]

EndoMAP.v1 charts the structural landscape of human early endosome complexes
https://t.co/f1aPzz5Gah

[Max Planck Institute of Biochemistry (MPIB) @MPI_Biochem]

Check out our latest study @NatureSMB: Establishing a consensus model for #ubiquitin chain assembly by HECT #E3 ligases:#cryoEM structures of #TRIP12 forming K29-linked and K29/K48-branched chains!

❕Publication: https://t.co/f7mmrjHKra

@SamuelMaiwald @UniLeiden

[Cell Chemical Biology @CellChemBiol]

#Technology Chemical tools to expand the ligandable proteome: Diversity-oriented synthesis-based photoreactive stereoprobes by @d_ogasa, @brumelillo, @bencravatt at @scrippsresearch @broadinstitute @harvardmed @MassGeneralNews https://t.co/NRD5Co8KEH

[Haselbach lab @HaselbachLab]

We are very excited to share our recent preprint on the nuclear import mechanism of the proteasome, driven by the multivalent adaptor AKIRIN2!
https://t.co/dJdiL7RAK8 🧵 (1/7)

[Rapé Lab @RapeLab]

Very excited to present the structural and mechanistic basis for stress response silencing by the monster E3 ligase SIFI.

https://t.co/Yay7eGCN1W

[Ann Cirincione @AnnCirincione]

Thrilled to see our work out in @naturemethods today! We applied prime editing to multiplexed dropout screens and benchmarked the tool’s ability to induce phenotypes when installing premature stop codons in essential genes.

[Cell Chemical Biology @CellChemBiol]

Online now! Chemical tools to expand the ligandable proteome: Diversity-oriented synthesis-based photoreactive stereoprobes by @d_ogasa, @brumelillo, @bencravatt, et al at @scrippsresearch @broadinstitute @harvardmed https://t.co/StYpozBFa4

[Daniel Scott @Daniel_C_Scott]

Structural basis for C-degron selectivity across KLHDCX family E3 ubiquitin ligases, now out @SpringerNature @NatureComms
Awesome collaboration with @sagarchittori .
@StJudeStructBio @MPI_Biochem @StJudeResearch #TPD #PROTAC #SchulmanLab

https://t.co/YvVZ21krmf

[Piskounova Lab @piskounova_lab]

6 years of work +
Over 2 years in review +
1 extremely talented graduate student @LeonaNease +
Amazing collaborators =

One extremely cool new mechanism that regulates metastasis through modification of the selenocysteine tRNA!

https://t.co/V5YMhZJV2J

[Chris Parker @_chrisgparker_]

Check out our recent Opinion in @TrendsinPharma on chemical proteomic binding site determination for non-covalent compounds

[Busino Lab @businolab]

Postdoctoral Position in @businolab
Come join us as a #postdoc studying the mechanisms by which the ubiquitin-proteasome system (UPS) controls cancer.
https://t.co/zNtuAw4oOs

[Michael Erb @Michael_A_Erb]

Open season on FOXA1! Our paper with the Cravatt group is out today in @MolecularCell. Please check out the updated data, including a new discovery that FOXA1 ligands mirror the effects of a nearby prostate cancer mutation. https://t.co/CiO6oRVx9N (1/2)

[Daniel Scott @Daniel_C_Scott]

Principles of paralog-specific degradation engaging the C-degron E3 KLHDC2, now out @SpringerNature @NatureComms
Awesome collaboration with @Richard_E_Lee and Taosheng Chen labs.
@StJudeStructBio @MPI_Biochem @StJudeResearch #TPD #PROTAC #SchulmanLab

https://t.co/FqdbKTGiaR

[Jakub Chrustowicz @chrustowicz_j]

Thrilled to share our latest preprint describing discovery of the charged, metabolically activated molecular glue degrader engaging the basic pocket of the structural CRBN homolog, YPEL5 - a subunit of the giant GID/CTLH E3 ligase!!!

https://t.co/XcAdbj7PNZ

[Dave Rhee @DaveYRhee]

@sshaolab @HHMINEWS @HarvardCellBio Congrats!!!

[Dave Rhee @DaveYRhee]

@WalterWChen1 Congrats!! 🎉

[Jimmy Hu @jimmy_k_hu]

Excited to share our new paper @PLOSGenetics that reveals how Shh signaling promotes myosin II activity to regulate tooth morphogenesis in mice! https://t.co/fMANk67NgE

[Randy King @rwkhms]

Very pleased to share our latest work on substrate identification of deubiquitylases, led by @VRossio, in collaboration with @PauloLabMS @GygiLab, available @CellChemBiol. Link below is active until July 17. https://t.co/Y4Q2cHHRN8