Di Pierro Lab

Physical Genetics, Theoretical Biology, Biological Physics

[Di Pierro Lab @DiPierroLab]

Genomic architectures are far more diverse than previously believed; yet, the physical processes that form this diversity should be similar, because molecular evolution is slow. In our latest work we argue that: 1/4

https://t.co/7r3ZJHexLm

[Luca Tancredi Barone 🏳️‍🌈 @lucatbarone]

Oggi abbiamo parlato di mammut congelati da 52.000 anni, ma soprattutto di come i ricercatori siano riusciti non solo a decifrarne il Dna, ma anche a sapere che forma tridimensionale aveva! 🤯@iosonoirene @DiPierroLab
Qui la puntata: https://t.co/v9kVUyLwwu

[Di Pierro Lab @DiPierroLab]

A multiphase continuum approach to chromatin organization. Sweat and ingenuity by @RLaghmach @potoyangroup . Congrats!

[PRX Life @PRX_Life]

New research presents MELON-4D, a method for describing mesoscale organization of DNA within cell nuclei. Applied to the Drosophila nucleus, it shows how internal forces sculpt nuclear geometry in eukaryotes.

Read the paper: https://t.co/GqdjXj5XTl.

[Sumitabha Brahmachari @sumitabha590]

New @BiophysJ article! Sustained enthusiasm by @BenjaminSRuben who started this project as an undergraduate has led to this. We studied how chromosomes behave under mechanical stress by simulating their axial stretching https://t.co/8WBl17YSrG

[Jumana AlHaj Abed @JumanaAHA]

@rita_strack To support both Turkey and Syria:

https://t.co/8kxeZHGMcl

Syrian Medical Society:
https://t.co/0yftGJhR53

Human Appeal Ireland relief:
https://t.co/hBEElK1rZe

@unicefusa
https://t.co/7ONRT0xa0d
evastating-earthquake-hits-syria-and-turkey/40794#Y-
RoFWJ4hlg.twitter

[Di Pierro Lab @DiPierroLab]

Work and ideas by @Vini_Contessoto, @odudcha, @erezaterez, Peter Wolynes, and José Onuchic. 4/4

[Di Pierro Lab @DiPierroLab]

Genomic architectures are far more diverse than previously believed; yet, the physical processes that form this diversity should be similar, because molecular evolution is slow. In our latest work we argue that: 1/4

https://t.co/7r3ZJHexLm

[Di Pierro Lab @DiPierroLab]

ii) due to their atypical structural organization, and unlike most mammals, the chromosomes of these mosquitoes are particularly sensitive to mechanical deformation. Could this be a new link between mechanical cues and gene regulation? 3/4

[Di Pierro Lab @DiPierroLab]

To this day, the structural ensembles of genes remain uncharacterized. Genes are too big for molecular simulations, yet too strongly affected by molecular factors to be modeled as a polymer. Here we propose a new approach to address this challenge. https://t.co/1qy09fiFMa

[APS Division of Biological Physics @ApsDbio]

We welcome your abstracts addressing how the regulation of macro biomolecular complexes drives the inner workings of a cell.. This session will feature invited talks by @shailajaseethar and @DiPierroLab. (2/3)

[Focus @Focus_it]

C'è una tavola periodica dei nuclei cellulari? https://t.co/QQY5ZNTVUz

[Di Pierro Lab @DiPierroLab]

ma tu guarda che ho trovato... https://t.co/IYbGRcGOdM

[Di Pierro Lab @DiPierroLab]

@PhysicsNEU @NortheasternCOS @northeastern

[Di Pierro Lab @DiPierroLab]

Check out our new paper in @ScienceMagazine ! A marriage of theory and experiments in collaboration with the Center for Theoretical Biological Physics, Benjamin Rowland @NKI_nl, @theaidenlab, @thednazoo, and many other institutions across the world. https://t.co/WWONIpEGQa

[Erez Lieberman Aiden @erezaterez]

Excited about a new collaboration between the Rowland, Onuchic, Di Pierro, and @theaidenlab labs and @thednazoo which was led by @odudcha Ahmed Elbatch, Claire Hoencamp and Sumitabha Brahmachari, appearing in @ScienceMagazine today. A tweetorial!

[Gene Regulation @generegulation]

Multiscale Genome Organisation, subgroup symposium of the Biophysical Society Annual Meeting, February 22, 2021 https://t.co/W4gYqA0mfy #virtualmeeting #3Dgenome

[Di Pierro Lab @DiPierroLab]

Today we launch the Nucleome Data Bank (NDB), a web-based platform to simulate and analyze the three-dimensional organization of genomes. The NDB is available at https://t.co/vXviYwCp6Z. Check it out! https://t.co/pdVgdhqEaU

[bioRxiv @biorxivpreprint]

Exploring Chromosomal Structural Heterogeneity AcrossMultiple Cell Lines https://t.co/c3FZOmyUYy #bioRxiv

[The PotoyanGroup @potoyangroup]

Experiments have shown many instances of liquid-like behavior of chromatin. Does that mean we can use liquid perspective to model/understand chromatin reorganization events in the nuclei? Or are we being too naive? :) @Real_MDiPierro @generegulation https://t.co/VHeWLfPtJC

[Di Pierro Lab @DiPierroLab]

Check it out!

[Davit Potoyan @potoyan]

Labor of pure love and a few dozen cups of coffee :) Thanks to the hard work of Rabia excited to share our new preprint. Also excited to have our long-time friend, chromatin guru and collaborator @Real_MDiPierro on board.