Xiangcheng Li

[Hepatoma Research @HepatomaRes]

🧬 #HCC Molecular Mechanisms Series | Part 1: Molecular Profiling and Precision Oncology

What connects lipid metabolism, ER stress, and HCC progression? ACACA may be a key missing link!

Could targeting lipid metabolism open new therapeutic avenues?

📖 https://t.co/e4wmSM7qhr

[Annals of Surgery @AnnalsofSurgery]

In this multicenter retrospective cohort of 2,905 patients undergoing esophagectomy after neoadjuvant CROSS or FLOT at 17 high-volume European centers, 14.6% developed an anastomotic leak, graded by ECCG severity. https://t.co/LUQvnpF3Pc

[Hepatoma Research @HepatomaRes]

What if some of the most interesting clues about HCC are hiding in the smallest RNA molecules?

circRNAs may have more than one trick up their sleeve—from influencing tumor behavior to potentially shaping treatment resistance.
@CoulouarnC @C_LOUIS1 @Erman_Akkus @JSHLiver

[Annals of Surgery @AnnalsofSurgery]

A predefined cost-effectiveness analysis of the DIPLOMA-2 RCT compared robot-assisted and open pancreatoduodenectomy in 268 patients across 14 centers in 6 European countries. https://t.co/FEHIxXPz3N

[Arndt Vogel @ArndtVogel]

Cadonilimab plus gemcitabine and cisplatin as 1L treatment for locally advanced or metastatic biliary tract malignancies: pls II bicureX trial
@NatureComms
https://t.co/81AVeptGGz
👉ORR 55.7%, DCR 85.2%, DoR 6.1 months,
👉PFS 8.0, OS 15.6mo
🧐support a role for CTL4 in BTC, promising ORR
@myESMO @ASCO @EASLedu @ILCAnews

[IHPBA @IHPBA]

Singapore, we're ready! 🎉

We can't wait to welcome you to #IHPBA2026

📅 Wed 28 Oct: Pre-Congress Courses, Early Career Retreat & Allied Health Session.

🕖 Registration:
07:00–10:00 Pre-Congress only
10:00–19:30 All delegates

📸 Share your moments and tag #IHPBA2026

[IHPBA @IHPBA]

#IHPBA2026 🚀 The IHPBA Early Career Group Retreat is underway in Singapore! 🇸🇬

An exciting day of learning, collaboration, networking and inspiring discussions as we bring together the next generation of HPB leaders from around the world 🌍

[Erman Akkus @Erman_Akkus]

Metabolic immune checkpoints (MICs) in cancer: from molecular mechanisms to challenges and opportunities in clinical translation

https://t.co/EDoBJlHNVx

[Frontline Gastro @FrontGastro_BMJ]

📰 New in Frontline Gastroenterology: a visual guide to immunotherapy in hepatocellular carcinoma

How does HCC evade the immune system, and where do checkpoint inhibitors act? This figure maps the immunosuppressive tumour microenvironment and the main drug targets.

🔑 Key points:
🧬 HCC cells overexpress PD-L1, downregulate MHC-I and secrete IL-10, TGF-β and VEGF
🛑 Tregs use CTLA-4 to block T cell co-stimulation via B7
😴 Exhausted CD8+ T cells co-express PD-1, TIM-3 and LAG-3
💊 Drug classes: anti-PD-1 (nivolumab, pembrolizumab), anti-PD-L1 (atezolizumab, durvalumab), anti-CTLA-4 (ipilimumab, tremelimumab) and anti-VEGF(R) (bevacizumab, cabozantinib)

Read the full article here👇
🔗 https://t.co/b4vwJkTLEj

@BritSocGastro @dr_aditi_kumar @OTavabie @DrJMKennedy @DunnePdj @TrevorTabone @eathar_s @IrenePerezMD @KGananandan @zare_benjamin @dtleiberman

[Elliot Tapper @ebtapper]

The first guidelines on preventive care in cirrhosis

[NEJM @NEJM]

A new review summarizes advances in therapy, including approval or expanded use of targeted agents, improved outcomes with antibody–drug conjugates and immunotherapy, and growing reliance on molecular profiling.

Read the Review Article “Advances in Systemic Treatment of Breast Cancer” by Sara Alsterlind Hurvitz, MD: https://t.co/wV3Xsv4CBY

[المرشد الجامعي @UniMentorSA]

طلاب الماجستير والدكتوراه… إذا كانت مراجعة الأدبيات تأخذ منكم أيامًا، اقرأوا هذا.

لا تجعلوا ChatGPT يكتب لكم مراجعة الأدبيات كاملة.

المشكلة ليست أن ChatGPT سيئ…
المشكلة أنك قد تحصل على نص جاهز، دون أن تعرف كيف بُنيت المراجعة أو لماذا اختيرت هذه الدراسات.

بدلًا من ذلك، جرّبوا ResearchCollab:

اختر Research Agent
أدخل موضوع مراجعة الأدبيات
3️⃣ حدّد الفلاتر المناسبة
4️⃣ سيبني لك:
• ملخصًا للموضوع
• مخططًا للمراجعة
• مسودة
• مراجع موثقة

ثم استخدم المسودة كنقطة بداية، وليس كبحث تسلّمه للمشرف.

راجع المصادر، اقرأ الدراسات، افهم الفجوة البحثية، ثم اكتب مراجعتك على أساس علمي.

أداة توفر عليك البداية… لكن الباحث هو من يصنع المراجعة.

جرّب ResearchCollab مجانًا:
https://t.co/rOrESwRsZ2

[Cholangiocarcinoma Foundation @curecc]

On Sunday, October 11, the Gerald Saddle Club in Gerald, MO, is hosting Hooves for Hope, a community fundraiser in honor of Allex Matuszek, who was recently diagnosed with cholangiocarcinoma at age 32. She is a new mother.

Allex has loved horses for nearly her entire life. This event brings together her love of horses and passion for advocacy and fundraising to raise awareness and critical funds for cholangiocarcinoma research.

This event will include a horse show from 10am-12pm, with lunch and live music to follow, and activities for all ages!

Tickets are $50 for the entire day of activities, including the horse show, or $10 for lunch only. All ticket and event proceeds will support CCF. Make sure to wear green to show your support!

Purchase tickets or donate: https://t.co/vGbsPQ3LTO

[Erman Akkus @Erman_Akkus]

Immune Checkpoint Inhibitor–Based Downstaging Therapy for Hepatocellular Carcinoma

#cancer #oncology #liver #hcc @OncoAlert

https://t.co/vGJ0gxo2Xw

[Arndt Vogel @ArndtVogel]

🔥great news🔥
FDA approves lirafugratinib for previously treated, unresectable, locally advanced or metastatic cholangiocarcinoma
https://t.co/u4Mr4ijEcu
👉expanding options for patients with FGFR2 fusions!
@myESMO @ASCO @ILCAnews @EASLedu

[The Yatrogenic Disaster @Halstedwi]

En cirujanos muy experimentados, hay 3 momentos de hiperfoco (estado de concentración profunda y sostenida en una sola actividad) donde repasamos paso a paso la cirugía a realizar y sus distintos escenarios: minutos antes de entrar a qx, durante y al finalizar. #cirugía #cirujano

[Tripti Tripathi @triptitips]

𝗠𝗼𝘀𝘁 𝗽𝗲𝗼𝗽𝗹𝗲 𝘁𝗵𝗶𝗻𝗸 𝗔𝗜 = 𝗖𝗵𝗮𝘁𝗚𝗣𝗧.

Not even close.

ChatGPT is what you see.

The real AI revolution is the massive ecosystem being built underneath it.

This AI Stack Map captures 100+ tools powering modern AI applications.

𝗧𝗵𝗲 𝗺𝗼𝗱𝗲𝗿𝗻 𝗔𝗜 𝘀𝘁𝗮𝗰𝗸 𝗹𝗼𝗼𝗸𝘀 𝘀𝗼𝗺𝗲𝘁𝗵𝗶𝗻𝗴 𝗹𝗶𝗸𝗲 𝘁𝗵𝗶𝘀:

LLMs → OpenAI, Claude, Gemini, Llama, Mistral
Agentic AI → LangGraph, CrewAI, AutoGen, CAMEL, Agno
RAG → LangChain, LlamaIndex, Haystack, GraphRAG
Embeddings → OpenAI, Voyage, Cohere, BGE
MCP → Connecting models with tools, data and systems
AI Security → Guardrails, Presidio, Lakera, Prompt Security
Observability & Evals → LangSmith, Langfuse, Phoenix, Ragas
Memory → Redis, Mem0, Zep, Neo4j, Chroma
Agent Frameworks → OpenAI SDK, Semantic Kernel, Google ADK, Bedrock
Automation → n8n, Zapier, Make, Airflow, Prefect
Vector Databases → Pinecone, Weaviate, Qdrant, Milvus, pgvector

But here’s the part that matters more than the logos.
𝗧𝗵𝗶𝘀 𝗶𝘀 𝗻𝗼𝘁 𝗮 𝘀𝗵𝗼𝗽𝗽𝗶𝗻𝗴 𝗹𝗶𝘀𝘁.
It’s a dependency graph.
Your RAG is only as good as your retrieval + embeddings.
Your agent is only as reliable as its tools + evaluations + guardrails.
Your memory is useless if you can’t observe when context becomes stale or wrong.
Your MCP layer becomes dangerous if permissions and governance are an afterthought.
And a “best-in-class” stack can still become a terrible production system.
Why?
Because AI systems rarely fail only inside one component.

𝗧𝗵𝗲𝘆 𝗳𝗮𝗶𝗹 𝗮𝘁 𝘁𝗵𝗲 𝗵𝗮𝗻𝗱𝗼𝗳𝗳𝘀.
Model → Retrieval
Retrieval → Context
Context → Agent
Agent → Tool
Tool → Memory
Memory → Evaluation

That’s where latency compounds, context gets lost, permissions leak, hallucinations propagate and reliability starts falling apart.

𝗧𝗵𝗲 𝗿𝗲𝗮𝗹 𝗺𝗼𝗮𝘁 𝗶𝘀𝗻’𝘁 𝗵𝗮𝘃𝗶𝗻𝗴 𝗺𝗼𝗿𝗲 𝗔𝗜 𝘁𝗼𝗼𝗹𝘀.

It’s designing how they work together.

A stack map tells you 𝗪𝗛𝗔𝗧 exists.

Production engineering decides 𝗛𝗢𝗪 it all survives contact with reality.

Which tool in your AI stack has become indispensable?

Save this map for your next AI build.
Repost it for someone designing an AI architecture.

#AI #ArtificialIntelligence #GenAI

[Elliot Tapper @ebtapper]

Dreams can come true.
>10 years of research, friendship, and team building with patients and caregivers brought us to these beautiful results.

Together we (@serperm) prevented falls in patients with cirrhosis.

https://t.co/SBgFiF0Maf

[Hepatoma Research @HepatomaRes]

🟣HCC Immunity Decoded | Part 3
ICI → Y-90 or Y-90 → ICI? Does treatment sequence matter in HCC?

🔹 Efficacy & toxicity
🔹 Biomarkers for treatment selection
🔹 The need for comparative evidence
📖https://t.co/pJ2UY11R77

[Arndt Vogel @ArndtVogel]

🔥off the press🔥
Precision oncology in GI-cancer: Mechanisms of action, indications and ongoing strategies to overcome primary and secondary resistance
Seminars in Cancer Biology
👉PO is fascinating , but complex
👉No magic bullet, much to consider: vertical & sequential pathway inhibitions, persister & resistance mechanisms, rechallenge...
Our thoughts👇
https://t.co/T2AA1lAlqw