π¨ PROTEUS: perioperative apalutamide moves into high-risk localized #prostatecancer
Just out in @NEJM
𧬠2109 men w/ high-risk localized or locally advanced PCa randomized to ADT + apalutamide vs ADT + placebo around radical prostatectomy.
π― Both stated primary endpoints met.
β οΈ But the trial deserves nuance. Thread π§΅
#ASCO26 @ASCO@PCF_Science
RAS finally getting drugged is one of the great stories in modern biology, and almost nobody outside oncology understands why it's such a big deal.
YOU'LL LEARN SOMETHING AWESOME TODAY.
i am going to keep this as understandable (and simple) as i can.
OPEN THE THREAD.
π§΅
Cheers, chills, and a standing ovation when RASolute 302 showed unprecedented survival on daraxonrasib for patients with progressive pancreatic cancer
Seldom do you sense youβre witnessing a historic moment in cancer care but this feels like ras targeting has arrived
#ASCO26
En bloc cystectomy is proving to be a powerful approach in challenging cx> post-EV/P, bulky fibrotic disease and EV/P progressors β¬οΈ R0 %, β¬οΈ EBL and improved node # We keep expanding our robotic en bloc cystectomy experience with LN ctDNA measurement .. innovation in tx requires π€ innovation in approach . credit to @EirikKjo@CleClinicUro
The FDA approves the signatera ctDNA assay for muscle invasive bladder cancer patients post surgery.
This is based on the results of Imvigor011 study (atezo vs placebo in ctDNA positives, surveillance for the ctDNA negatives).
It opens a new chapter for personalised therapy in urothelial cancer. Focusing on early treatment for those patients that need it and sparing those at lower risk potentially harmful treatment makes sense.
βIt is the first companion diagnostic approval in the field of blood-based MRD.β
https://t.co/dGAIblVrzc
We recently got a brand spankingππ new @PhotocureASA Blue π light system @CleClinicUro and I am slowly convincing 1 resident at a time the incredible value in #bladdercancer starting w/ @eiftu
We recently got a brand spankingππ new @PhotocureASA Blue π light system @CleClinicUro and I am slowly convincing 1 resident at a time the incredible value in #bladdercancer starting w/ @eiftu
Force of nature #hadleywood giving the #WomenofGURS lecture at @SocietyGURS Congress, sharing her experiences and incredible insights. Lucky to call her a colleague, mentor and friend π€
@mdewittfoy
It is harder than ever to believe in our democracy. It has been attacked by billionaires and hollowed out by its failure to respond to working peoplesβ struggles.
But on this campaign, we dreamed of a new day. And we have won it together.
Work/life balance achieved this morning with a super educational poster session followed by a massive watch party and celebration of the PREM LEAGUE CHAMPIONS @LFC! #AUA25#TopoftheLeague