Scottie Friedman

[NASA Administrator Jared Isaacman @NASAAdmin]

We go where we need to be, and today that was @NASAKennedy.

Some of my senior engineers and I spent time at @blueorigin with @JeffBezos and @davill, speaking with the workforce and seeing the damage at LC-36 firsthand. I appreciated the opportunity to hear directly from those working through the aftermath and better understand the challenges ahead.

There is a lot of work to do, but this is exactly why people choose careers in aerospace, whether at NASA, Blue Origin, or across the industry. The talent in this field thrives under pressure and performs at its best when solving the toughest problems.

We have been saying for months at NASA that we are not going to sit on our hands and wait for the capabilities necessary to achieve the nation’s most pressing objectives. We are going to take an active role alongside our partners, just as we did in the 1960s, to overcome setbacks, remove obstacles, and deliver the intended outcomes.

@NASA is committed to helping the Blue team recover, continue to advance their lunar lander and get New Glenn back to launching as soon as safely possible.

America’s greatest achievements in space were never the result of avoiding setbacks. They came from overcoming them. We have done it before, and we will do it again🇺🇸

[Scottie Friedman @friedms]

@dhaber @pmarca For 3,000 years, David beat Goliath with a stone.

Now David has a supercomputer. 😎

[Richard Sutton @RichardSSutton]

The bitter lesson in 26 words:

Don’t be distracted by human knowledge, as AI has been historically.
Instead focus on methods for creating knowledge that scale with computation, like search and learning.

[Po-Shen Loh @PoShenLoh]

Wow, this is the message I’ve been giving in hundreds of talks around world. I’ve been advocating a philosophy I call https://t.co/XyMnoxTtp4: enjoy delighting other people and thinking. I happen to be in Rome today #PiDay. Love to chat! Great that @Pontifex has #math background.

[Po-Shen Loh @PoShenLoh]

Would love to collaborate (https://t.co/g8tCKJ6xhv). Love how you merge your analytical (math!) background with love for humanity. You're perfectly positioned to lead today. I'm Carnegie Mellon math prof & was National Coach of USA Math Olymp team. Now I educate people to love ppl + love thinking. Main focus is on humanity after AI, crossing perspectives from university to business to social. I visit 100+ cities/yr, creating solutions as a social entrepreneur and giving public lectures. Going to Africa via Rome in Dec. Might your office like to chat? [email protected]

[Elon Musk @elonmusk]

AI must pass the Galileo test

[Garry Kasparov @Kasparov63]

Terrible. Promoting equality does not require diminishing excellence.

[Massimo @Rainmaker1973]

Scientists at the University of Florida have created a breakthrough mRNA cancer vaccine that erased deadly brain tumors in early human trials without chemo or radiation.

Tested on four glioblastoma patients, the vaccine reprogrammed their immune systems within 48 hours to attack the tumor.

Built from each patient’s own tumor cells and delivered via lipid nanoparticles, it showed success similar to earlier tests in mice and dogs. It is now moving into Phase 1 pediatric trials.

[Elon Musk @elonmusk]

Grok will be used nationwide by El Salvador for personalized education!

[Ray Dalio @RayDalio]

Someone who doesn’t have much can be more generous giving a little than a rich person giving a lot. Some people respond to the generosity while others respond to the money. You want the first type with you, and you always want to treat them generously.

When I had nothing, I was as generous as I could be with people who appreciated my generosity more than the higher levels of compensation others could afford to give them. For that reason, they stayed with me. I never forgot that, and I made a point of making them rich when I had the opportunity to do so. And they in turn were generous to me in their own way when I needed their generosity most. We both got something much more valuable than money—and we got the money too.

Remember that the only purpose of money is to get you what you want, so think hard about what you value and put it above money. How much would you sell a good relationship for? There’s not enough money in the world to get you to part with a valued relationship. #principleoftheday

[Chrisman @chrisman]

Today was our first meeting with the cabinet ministers of a sovereign government who want to roll out Synthesis Tutor to all their nation’s kids.

People laughed when we said this would happen.

[Chrisman @chrisman]

Elon nails exactly what's wrong with education here and what needs to change.

You may not know he actually started a remarkable school at SpaceX for his kids based on his principles...

The school was called Ad Astra, Latin for “to the stars”.

Elon hired @josh_dahn to build and run the school. When Elon’s kids graduated, Josh and I cofounded @synthesischool together.

Our goal is to take the best parts of the SpaceX school and make them accessible to everyone.

Elon famously follows a “first principles” approach. The primary principle of the school:

A good education should produce people who can SOLVE PROBLEMS — real, complex problems with a team. Like how to colonize Mars. Not fake school worksheet problems.

This principle was embodied in a class at the school called “Synthesis”. In the class, kids worked in teams to solve problems via complex games and simulations.

The skills they build in Synthesis — working with a team, making tradeoffs, risk assessment and critical thinking — are the foundational skills they’ll need to solve problems in any domain.

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[Elon Musk @elonmusk]

We should send rockets not at each other, but rather to the stars

[Investment Wisdom @InvestingCanons]

Warren Buffett's tribute to Charlie Munger:

[Sam Altman @sama]

one of the great pleasures in life is finding undiscovered talent, enabling them with high conviction, and watching them bend the trajectory of things

[Tanishq Mathew Abraham, Ph.D. @iScienceLuvr]

Towards Conversational Diagnostic AI

abs: https://t.co/baJefLLg0f

Another amazing paper from the Med-PaLM team at @GoogleDeepMind!

Introduces AIMIE, an LLM based AI system optimized for clinical history-taking and diagnostic dialogue. Trained on medical QA, summarization, and medical conversation dialogue datasets. A self-play (RLAIF) approach is used where AIMIE played the role of five agents: a vignette generator, simulated dialogue generators (patient, doctor, and moderator agents), and a self-play critic to provide feedback to the doctor agent. AIMIE uses a chain-of-reasoning process to provide informed and grounded responses to the patient.

Evaluation is done with an "Objective Structured Clinical Examination (OSCE)" which includes patient actors simulating real-life clinical scenarions. Performance is compared to primary care providers (PCPs), total of 149 scenarios were used. AI-based autoevaluation was also performed. The OCSE indicated AIMIE showed higher DDx accuracy than PCPs while AI evaluation showed AMIE matched PCPs’ efficiency in acquiring information. Additionally the patient actors rated the conversation quality of AIMIE higher than the PCPs.

[Tim Urban @waitbutwhy]

I'm yet to talk to anyone of any political leaning who wants airlines doing anything but hiring the most qualified pilots, regardless of race or gender.

It would be great marketing for an airline to respond to these trends by announcing, "we believe first and foremost in safety, which is why we are reaffirming our commitment to hiring the absolute best pilots, regardless of who they are."

Airlines can of course still work on making the pilot pipeline more accessible to a range of demographics, but the final stage of that pipeline should (obviously!) be an entirely meritocratic hiring process.

[Massimo @Rainmaker1973]

How to calculate the value of the sine, cosine, tangent and cotangent of the angle 0°, 30°, 45°, 60° and 90°.

The fingers are numbered sequentially numbers N={0, 1, 2, 3, 4}.

[🎞️ Minor]

[Tim Brzezinski @TimBrzezinski]

Area of a circle (v2) https://t.co/xKtSvo44d7

[Mike Bloomberg @MikeBloomberg]

Recent international test scores are the latest sign of the crisis in American schools. And the only thing more alarming is the complacency of our leaders as more and more students fall behind. Education should be at the top of the agenda for every elected official and candidate. https://t.co/dp5Yzpp45z