Tim Shaw 🇺🇸..🇹🇼..🇺🇸

Assistant Member/Professor, Bioinformatian & Cancer Researcher @ Moffitt. Interest in Immuno-oncology, ER stress, and alternative splicing. he/his

[Dr. Jean Fan @JEFworks]

As academic audit culture grows (now pre-approvals for conferences, foreign collabs, etc), I hope students will remember there's another way: academia built on mutual trust/obligation through collective effort

My take on the neoliberal academic ecosystem: https://t.co/zJhCta8sDD

[Tim Shaw 🇺🇸..🇹🇼..🇺🇸 @gatechatl]

Congrats Ada Lau (one of our ODYSSEY trainees) getting her research highlighted at the #MoffittScientificSymposium @MoffittNews

[Moffitt Cancer Center @MoffittNews]

At #MoffittScientificSymposium, Ada Lau shares research investigating immunosuppressive features of the multiple myeloma tumor microenvironment following CAR-T therapy. Findings revealed CD8+ immune responses between complete response and progressive disease samples, highlighting interferon pathway activation in responders and TNF-alpha signaling in progressive disease.

[Moffitt Cancer Center @MoffittNews]

At #MoffittScientificSymposium, Ada Lau shares research investigating immunosuppressive features of the multiple myeloma tumor microenvironment following CAR-T therapy. Findings revealed CD8+ immune responses between complete response and progressive disease samples, highlighting interferon pathway activation in responders and TNF-alpha signaling in progressive disease.

[Zihai Li, MD, PhD @Zihai]

Science does not have to be complicated: Direct injection of an immune therapy drug into tumour reduces side effects without compromising efficacy. https://t.co/PLwfA0Iv4i

[Retraction Watch @RetractionWatch]

"Why wait 6 months for reviewer 2 when you can get roasted by an #AI in seconds?" A metascientist's thought exercise.
https://t.co/NXQf1scf3f
Meanwhile, an AI society announces it's incorporating LLMs into its review process.
https://t.co/gI95hvg8Mg

[Tim Shaw 🇺🇸..🇹🇼..🇺🇸 @gatechatl]

AI can accelerate discovery through algorithmic optimization, but translating those discoveries into impact remains a human endeavor.

[Eric Topol @EricTopol]

On the lack of compelling evidence that medical AI is improving patient care, and what to do about it, a @NatureMedicine editorial https://t.co/kQiN6L2ai7

[Eric Topol @EricTopol]

On the lack of compelling evidence that medical AI is improving patient care, and what to do about it, a @NatureMedicine editorial https://t.co/kQiN6L2ai7

[Xuefeng Wang @xuefwang]

CGPA paper is finally out!

[Dr. Jean Fan @JEFworks]

When polishing scientific figures for publication, I try to limit fonts + font sizes to reduce visual noise. But doing this by hand is tedious.

So I vibe coded a web app to standardize text in SVGs: https://t.co/0JRhstRhAp

Try it out! Spot the differences. Hope it's helpful

[Dr. Patrick Hwu @PatrickHwuMD]

#ScienceSaturday

❓ How can we turn T-cells into cancer-fighting “soldiers” without changing their DNA?

➡️ A new study in Nature Biotechnology introduces an all-RNA platform that can turn T-cell genes on or off using epigenetic CRISPR tools called CRISPRoff and CRISPRon. Instead of cutting or rewriting DNA, this method “reprograms” genes by adding or removing chemical marks — allowing researchers to boost or silence key immune functions safely.

➡️ The team showed this can enhance CAR T-cell therapies, helping immune cells better recognize and attack tumors while reducing potential side effects linked to traditional gene editing.

🌟 Congratulations to senior authors Alex Marson, Luke Gilbert, Brian Shy, and Justin Eyquem of UCSF, Arc Institute, and Gladstone Institutes for this exciting advance — a big step toward the next generation of precise, safer immunotherapies.

🔗 Read more in Nature Biotechnology: https://t.co/8QumYGnqot

@LukeGilbertSF @UCSF @UCSFCancer @UCSFMedicine @arcinstitute @GladstoneInst @j_eyquem

[Science Magazine @ScienceMagazine]

A recent special issue of Science explores the immune system at the molecular and cellular level and how it has evolved to govern multiple facets of human health.

Learn more: https://t.co/ElqZXrSM53

[Xuefeng Wang @xuefwang]

SmartImpute is now online with Cell Reports Methods https://t.co/kzKm3sI2F0

[ISCB News @iscb]

RSG SE-USA presents America’s 3rd #ComputationalBiology Symposium taking place December 11–13, 2025 at the University of Florida in St. Petersburg. 

This is a great chance for students to connect and plan for the future of the field!

[ISCB News @iscb]

If you’d like to present at the symposium, submissions are being accepted until Friday, August 15. 

Contact and submission details are in the flyers!

[nature @Nature]

Researchers have been sneaking secret messages into their papers in an effort to trick AI tools into giving them a positive peer-review report

Read the full story: https://t.co/1kOYRLf72i

[David R. Liu @davidrliu]

In a medical milestone, a customized base editor was developed, characterized in human and mouse cells, tested in mice, studied for safety in non-human primates, cleared by @US_FDA for clinical trial use, manufactured as a complex with an LNP, and dosed into a baby with a severe, rapidly progressing genetic disease... all in an astounding 7 months. Best of all, the infant patient shows apparent benefit. Congratulations to @kiranmusunuru, Rebecca Ahrens-Nicklas, and other team members for this heroic and inspiring effort, which has implications for the hundreds of millions of patients that suffer from thousands of genetic diseases.

https://t.co/wsgvvRYPVM

[Xuefeng Wang @xuefwang]

Congratulations to Michael J. Schell, Ph.D., FASA.
Well deserved! 🎉🎉🎉
#Moffitt #ASA #Biostatistics #CancerResearch

[Xuefeng Wang @xuefwang]

Using ROICellTrack on urothelial carcinoma, we identified distinct cancer-immune cell mixtures linked to transcriptomic & morphological signatures. Check out our recent paper with @song_xiaofei and @UrogerliMD.

https://t.co/De0uTYDUF4
#SpatialTranscriptomics

[Erin George @ErinGeorgeMD]

Thanks to the @KayYowFund we will be able to begin some exciting research challenging current treatment paradigms in ovarian cancer that will hopefully improve outcomes. Thank you so much for your generous support!

[Riyue Sunny Bao, PhD @RiyueSunnyBao]

#MCBIOS2025 day 2 !! in beautiful Salt lake city @UUtah , theme - harnessing #artificialintelligence to transform #humanhealth.

Dr. Tim Shaw @gatechatl and I will be co-chairing a session on #AI for #ImmunoOncology, featuring Dr. Linghua Wang @IamLinghua on her brand new published work #CAF, Dr. Xuefeng Wang @xuefwang #data harmonization for cancer #models, and Dr. AC Tan (not on twitter) @huntsmancancer president of MCBIOS speaking on #ditigaltwins. We will have 30 mins panel discussion at the end as well.

Join us @ 11:00 Mountain time!! Exciting 🚀

slide credited to: Dr Tim Shaw