Top Tweets for #Cdk1
🚀From Bench to Paper | New in #Science: A Mitotic Architectural Switch Safeguards the Genome
A phospho-regulated switch reprograms #TRAIP in mitosis to ubiquitylate the replisome, enabling fork breakage and chromosome arm joining. #TTF2 tethers Cyclin B–#CDK1-phosphorylated TRAIP to Pol ε, safeguarding genome integrity before segregation.
#Science #Mitosis #DNAReplication
🚀From Bench to Paper | New in #Science: A Mitotic Architectural Switch Safeguards the Genome
A phospho-regulated switch reprograms #TRAIP in mitosis to ubiquitylate the replisome, enabling fork breakage and chromosome arm joining. #TTF2 tethers Cyclin B–#CDK1-phosphorylated TRAIP to Pol ε, safeguarding genome integrity before segregation.
#Science #Mitosis #DNAReplication
Scientists uncover a surprising role for the cell cycle protein #CDK1, according to a study that expands the protein’s functions to include regulating how cells in the epithelium adhere to each other. @margariddantas @GloerichLab @UMCU_Intl https://t.co/FlzQFoyakm
Scientists uncover a surprising role for the cell cycle protein #CDK1, according to a study that expands the protein’s functions to include regulating how cells in the epithelium adhere to each other. @margariddantas @GloerichLab @UMCU_Intl https://t.co/FlzQFoyakm
Article✍️#CDK1-mediated #phosphorylation of #USP37 regulates #SND1 #stability and promotes #oncogenesis in #colorectal #cancer. From Dr. Liu @UniversityofScienceandTechnologyofChina; @ELSpharma.
https://t.co/l5uxpM5O6G.
15/🧵 Importantly, and as predicted, lowering #Cdk1 activity sensitizes the cytoplasm for even more local mitotic delays and consequential #extrusions: MANY OF THEM!
#Flavopiridol (#Alvocidib) is a broad spectrum and competitive #inhibitor of #CDKs, inhibiting #CDK1, #CDK2, #CDK4 with IC50s of 30, 170, 100 nM, respectively. #drugdiscovery. https://t.co/nSTD4oNQbi
to better understand how alterations of this mechanism may cause diseases like #Cancer
Compartmentalized control of #Cdk1 drives mitotic spindle assembly @CellReports @Ceinge
https://t.co/CfCP2W1OUz
How frequent is cellular #quiescence outside of G1, with high #Cdk1 activity? Movies of #Cellcycle under stress provide answers @JCellBiol
.@Orland_AM, Marchand, @TaylorK47997870, @maraxen0, @noh_jungsik @CellUtsw use machine learning & spectral imaging to show how the stress-activated transcriptional repressor Xbp1 can drive cellular #quiescence even outside the G1 #CellCycle stage https://t.co/1EZf8fDJaT
#USP7 inhibitors trigger untimely #CDK1 activation throughout #cellcycle via #PP2A & cause #DNAdamage in replicating cells - new mechanism underlying their toxicity
@Emlecona @KP_twitt_llo and coworkers @CBMSO_CSIC_UAM @CNIOStopCancer @karolinskainst
https://t.co/XCqA7Kw2uw
#NU6102 is a potent #CDK1 and #CDK2 #inhibitor with IC50s of 9.5 nM and 5.4 nM for CDK1/cyclinB and CDK2/cyclinA3, respectively. #CervixCancer. #drugdiscovery. https://t.co/iLdQcMSeVX
#CryoEM structures by @tatsuofukagawa1 and coworkers explain how CENP-C #phosphorylation by #CDK1 controls its recognition of #centromeric CENP-A nucleosomes and regulates #kinetochore dynamics
https://t.co/W3JVuigJFo
Using an integrated #proteomics approach to study the kinome-phosphatome, the @KettenbachLab finds that the kinase #CDK1 supports #mitosis by directly and indirectly inhibiting the formation of PP2A holoenzyme. #MassSpectrometry @GeiselMed @ishanasa https://t.co/xdLpcfb2SO
Using an integrated #proteomics approach to study the kinome-phosphatome, the @KettenbachLab finds that the kinase #CDK1 supports #mitosis by directly and indirectly inhibiting the formation of PP2A holoenzyme. #MassSpectrometry @GeiselMed @ishanasa https://t.co/xdLpcfb2SO
Using an integrated #proteomics approach to study the kinome-phosphatome, the @KettenbachLab finds that the kinase #CDK1 supports #mitosis by directly and indirectly inhibiting the formation of PP2A holoenzyme. #MassSpectrometry @GeiselMed @ishanasa https://t.co/xdLpcfb2SO
Check out the latest paper from our lab, work by @GadrePurna, on the role of #Cdk1 and #CyclinE during #Drosophila #spermatogenesis ! Congrats Purna!! Am extremely happy! 😃🤩 #germline #cellcycle #flypapers @TIFRScience @KRay_Lab
Control #Epigenetico global mediado por #Cdk1 - #Epigenetica #ESC- Cdk1 Controls Global Epigenetic Landscape in Embryonic Stem Cells https://t.co/qdXOHDUj97
#Cdk1 y la regulacion #epigenetica en #celulas troncales. #ESC #histonas #Epigenomica - Cdk1 Controls Global Epigenetic Landscape in Embryonic Stem Cells https://t.co/upk8dsnstz
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