Top Tweets for #FragilityIndex
How strong isthe evidence for QT grafts in ACL reconstruction?
Most RCTs are statistically fragile — just 1 patient could flip the results. Caution needed in interpretation.
#ACL #Orthopaedics #SportsMedicine #FragilityIndex
Reach here: https://t.co/qqNxMTnX9P
📢 Launching a New Study for Lasting Impact! 🌍
Today, @IOMSouthSudan & @DukeU will present significant #Fragilityindex findings in 🇸🇸
Through the study, we aim to shift from crisis response to sustainable recovery.
With thanks to @EUinSouthSudan for making this possible.
A paper published last week reminded me of the #FragilityIndex concept to assess the stability of the results of clinical trials 1/7
#MethodologyMonday #86
How fragile are results from trials comparing neuraxial anaesthesia and general anaesthesia for hip fracture surgery? New correspondence by Restrepo et al
#statistics #fragilityindex #hipfracture
https://t.co/Tggu41epGx
What is the quality of evidence of randomized trials in hernia? Maybe not as good as we think. #FragilityIndex #RCTs @THeniford @plasticfish83 @GregoryTScarola @AlexisHollandMD @CMC_GSResidents @AmericanHernia @eurohernias
https://t.co/2CFi2U7WFm
Statistical fragility of reporting hemidiaphragmatic paralysis after brachial plexus blocks in randomized controlled trials: a systematic review. A
#FragilityIndex #anesthesiology
https://t.co/ZbjsyV460b
Sloppy methodology with a low powered study where only a few poorly completed death certificates (ie cardiac arrest is not a cause of death) could completely change the statistical significance of the findings by anonymous authors = dubious conclusions. #fragilityindex
Florida just announced the results of an analysis that they performed, saying the results show "an increased risk of cardiac-related death among men 18-39" for the mRNA vaccines, and recommend this group not receive these vaccines.
Is this justified? Let's look at the data...
@AdanZBecerra1 @stephensenn @learnfromerror @MaartenvSmeden @statsepi This is the #fragilityindex (which is a measure of how many events the statistical significance of a result depends on) applied to critically ill mRCTs reporting a statistically significant effect on mortality @IntensiveBot https://t.co/BCG3glote4
@AdanZBecerra1 @stephensenn @learnfromerror @MaartenvSmeden @statsepi This is the fragility index applied to perioperative trials with statistically significant effect on survivial. The Fragility Index may complement frequentist analysis and provide quantitative assessment of robustness. #fragilityindex @IntensiveBot https://t.co/kGrvFGrAHy
A review of the fragility index, a metric which may be used to assess the robustness of a study's statistical significance. #statistics #pvalue #fragilityindex @QueensuPHS https://t.co/NTFQGLcgzk
@FrancesLumsden How interesting. I wonder what would happen if @scotgov analysed the #FragilityIndex for Scotland alone.
Our recent #hiparthroscopy systematic survey on RCTs published in @ArthroscopyJ resulted in a low #Fragilityindex, indicating that the findings tended to be fragile.
Link below
https://t.co/B4yaDPCoLl
📣 Journal Club Tool #FragilityIndex:
Measures trial robustness
Calculates # of pts required to lose statistical significance
i.e. Would 1 more pt w/the outcome change statistical significance? Would 10 more change it?
Learned from @GermHunterMD at #IDWeek2020 #toppaperstxid
Now on @JAMAInternalMed .The basis of a good trial design is the delicate balance between the number of patients whose treatment is based on randomization and the solidity of the results.The #fragilityindex is an important first step in this direction. https://t.co/Z6HpN7Q0Pb
Not only was I ratio-ed by #MedTwitter, I was also reprimanded by @RogueRad on the pod.
As a (former) bike racer, current AF ablation doc, and co-author of a #FragilityIndex paper, I have b/c accustomed to tension, frustration and criticism/abuse. So bring it on!
“IN THE TIMES of #COVID19”. @RogueRad tweets a joke & @drjohnm tweets a serious note of MDs and social policies. BOTH R met w similar outraged reaction. They share their candid experience on #OutspokenOncology
Don’t miss this unfiltered R-rated podcast
https://t.co/JLDJp4HxxB
@oncology_bg @VPrasadMDMPH @ADAlthousePhD @statsepi Researching the question (vulnerability of findings/conclusions to minor perturbations) is a good idea. Relying on the #fragilityindex as sole arbiter not ideal.
@oncology_bg @VPrasadMDMPH @ADAlthousePhD @statsepi The question (how vulnerable are these findings/conclusions to minor perturbations) and idea (using a number to express this) are good. But it’s naive to expect ultimate truth from a number without context. #fragilityindex
Look 👀! Our latest paper is out.Thanks for all your help and hard work team! #BladderBowelDysfuntion #Altmetrics #FragilityIndex @jpurology @DanKeefe12 @JHannickMD @laudakris @karenmilford @JoanaRosaP @nirajm @KoyleMarty @ArmandoJLorenzo
🆕 JPUrol article: Trends and relevance in the bladder and bowel dysfunction literature: PlumX metrics contrasted with fragility indicators
https://t.co/rIWNfa9Niz
https://t.co/SDJcmlYFZZ
How robust (or fragile) are the RCTs our very #guidelines rely on? #Crohns #ACG - Read my latest #editorial on European Journal of Gastrology & Hepatology to find out more about #fragilityindex
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