Top Tweets for #IMvigor010
ctDNA — a hot topic in postop #bladdercancer for minimal residual disease — compelling data from #IMvigor010 to drive ongoing trials from #IMvigor011 and @ALLIANCE_org #MODERN trial (open @utswcancer!)
#UromigosLive24 @Uromigos
Very impt data presented by @tompowles1 at #EAU24, helping tremendously in telling the story of ctDNA in #bladdercancer. Nice build on the @Nature paper he led from #IMvigor010 a couple of yrs ago!
Serial ctDNA testing from IMVIGOR11 (post cystectomy in muscle invasive bladder cancer) show that ctDNA-ve patients (n=171) with a minimum of 12months follow up have 10% relapse rates and almost no deaths #EAU24. Do we need to give adjuvant therapy to those as such low risk?
@MattGalsky highlights role of ctDNA to select patients who need adjuvant IO. @SUO_YUO #SUO22
Shout out to @tompowles1 for his critical work on ctDNA #IMvigor010 &ongoing ctDNA driven trials IMvigor011 & #MODERN trials @ALLIANCE_org @montypal @AbhiTrip87 @sonpavde @apolo_andrea
Molecular residual disease detection with a tissue comprehensive genomic profiling-informed personalized monitoring assay: an exploratory analysis of the #IMvigor010 observation arm. Presented by Amanda Young @FoundationATCG. #GU22 coverage > https://t.co/jDiw9KjOld @zklaassen_md
@PGrivasMDPhD now giving updates in #bladdercancer - giving adjuvant landscape first, highlighting #ambassador trial ongoing & ctDNA data of pts at high risk for recurrence from #IMvigor010. Beijing GU oncology conference - 北京泌尿肿瘤青年论坛
Preplanned exploratory biomarker analysis in the ctDNA-positive patient population of #IMvigor010. @tompowles1 @QMBCI joins @CaPsurvivorship @NUFeinbergMed for a discussion on UroToday > https://t.co/PYCfJ3n9Pm
Preplanned exploratory biomarker analysis in the ctDNA-positive patient population of #IMvigor010. @tompowles1 @QMBCI joins @CaPsurvivorship @NUFeinbergMed for a discussion on UroToday > https://t.co/PYCfJ3n9Pm
#IMvigor010, although interim OS mirrored DFS results (no significant difference), the data are not yet mature and OS could also not be formally tested as a secondary endpoint based on the primary DFS findings; mature OS data will be reported in due course #atezolizumab #MIBC
Important data #CheckMate274 primary endpoints of DFS in ITT & PD-L1+ populations + for adjuvant nivolumab #GU21
Open Questions: Subgroup UTUC - better chemo? #POUT @AlisonBirtle
Biomarker use (ctDNA, PD-L1)? @tompowles1 #IMvigor010 Drop out rate? OS pending @MattGalsky
Bottom line: More clinical trials a must. And here's a teaser: We need to move data @tompowles1 presented at @myESMO #ESMOImmuno20 fwd. Out of all biomarkers I've seen so far, the @NateraOncology ctDNA work in #IMvigor010 is the best predictor of IO-assoc DFS & OS benefit. (9/9)
Conclusion: #IMvigor010 #Signatera analysis answers many questions lingering in the ctDNA MRD field. Implications for clinical practice (with confirmation) and future trial design are clear. What other adjuvant studies could benefit from #MRD testing❓
4/n Back to #IMvigor010, which looked at MIBC patients randomized 1:1 between adj atezo vs observation. Study itself unfortunately was negative for both OS and PFS in the IIT population. PD-L1 and all other traditional subgroup analyses unable to identify subgroup of responders
Another milestone for my friend @MattGalsky Can’t count how many contributions for #bladdercancer patients he has done so far and will still do. Can’t wait to see how this curve from #IMvigor010 turns into + @BladderCancerUS @PGrivasMDPhD @powles_tom @sonpavde @apolo_andrea
Prolonging overall survival in patients with muscle-invasive #BladderCancer @PGrivasMDPhD @fredhutch and @CaPsurvivorship @NUFeinbergMed discuss updates in the #MIBC setting, including #IMvigor010 and #JAVELIN100. #ListenNow on UroToday > https://t.co/UZFlbTg4YQ @SeattleCCA @UW
Prolonging overall survival in patients with muscle-invasive #BladderCancer @PGrivasMDPhD @fredhutch and @CaPsurvivorship @NUFeinbergMed discuss updates in the #MIBC setting, including #IMvigor010 and #JAVELIN100. #ListenNow on UroToday > https://t.co/UZFlbTg4YQ @SeattleCCA @UW
Prolonging overall survival in patients with muscle-invasive #BladderCancer @PGrivasMDPhD @fredhutch and @CaPsurvivorship @NUFeinbergMed discuss updates in the #MIBC setting, including #IMvigor010 and #JAVELIN100. #ListenNow on UroToday > https://t.co/UZFlbTg4YQ @SeattleCCA @UW
. @CaPsurvivorship & @PGrivasMDPhD discuss recent updates in the #mUC disease space together they review multiple presentations given during @ASCO #ASCO20 @urotoday #AMBASSADOR #IMvigor010 #JAVELIN #PROOF302 #MedEd @siadaneshmand @MattGalsky @tompowles1 https://t.co/UKZM3BOTjI
#Cáncer | #IMvigor010:
Adj. Atezolizumab no alcanzó el objetivo primario de SLE (HR: 0,89)
HR para PD-L1 enriquecido grupo 1.01 ¿La configuración adyuvante puede no ser el mejor lugar para IO? #ASCO20
IMvigor010:
⭕️Adj. Atezolizumab did not meet the primary endpoint of DFS (HR:0.89)
⭕️HR for PD-L1 enriched group 1.01
⭕️The adjuvant setting may not be the best place for IO?
#ASCO20 @OncoAlert @ASCO
M.Hussain et al. @tompowles1 @cdanicas @PGrivasMDPhD @OncoBellmunt @Uromigos
#IMvigor010 Primary analysis from a PIII randomized study of adjuvant Atezolizumab vs observation in high-risk #MIUC. Presentation by Maha Hussain, MD, FACP, FASCO @LurieCancer. #ASCO20 coverage by @TheRealJasonZhu @LevineCancer on UroToday > https://t.co/ekdBh4bIhJ @ASCO
@DrChoueiri @montypal @Uromigos @neerajaiims @PauloBergerot @PGrivasMDPhD @DrVaishampayan @TiansterZhang @ERPlimackMD @ALLIANCE_org @DrRosenbergMSK @morr316 Disappointed from the negative results of the phase 3 #IMvigor010 study of adjuvant #atezolizumab vs observation in #MIBC. Our adjuvant @ALLIANCE_org AMBASSADOR #pembrolizumab study is enrolling & allows enrollment of pts with more aggressive tumors (+margins) #bladdercancer
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