Top Tweets for #Notch3
Now online!👏
Targeting #NOTCH3 to eradicate dormant and therapy-resistant #multiplemyeloma cells
Full text 📲
https://t.co/8wf5VlV7DV
#NotchSignaling
#Dormancy
#Bortezomib
#DrugResistance
ICYMI: #Auranofin Synergizes with #Cisplatin in Reducing Tumor Burden of Notch-Dependent #OvarianCancer https://t.co/EQtFK0IV1c
#Notch3 #OpenAccess
📍WCS 2025 | Barcelona
World Congress of Stroke 2025🧠
#WCS2025 #Barcelona #Science #Research #CADASIL #Neuroscience #BiomedicalResearch #TeamWork #iPSC #ExtracellularVesicles #NOTCH3 #TranslationalResearch #ProudMoment
This new study highlights the role of #NOTCH3 in mediating fatty acid oxidation in #meningiomas, and a potential mechanism for increased malignant potential of NOTCH3 + meningiomas.
https://t.co/XjUB0IwmWq
#OnlineFirst: #Auranofin Synergizes with #Cisplatin in Reducing Tumor Burden of Notch-Dependent #OvarianCancer, by Mara P. Steinkamp, Hua-Ying Fan, and colleagues https://t.co/EQtFK0IV1c
@UNMCCC @UNMHSC @UNMPathology #Notch3 #OpenAccess
https://t.co/9A8hTfbX7M Check out our recently published peer reviewed article on potential #Celltherapies #Immunotherapies and #smallmolecule targets for #Notch3 mutants causing #CADASIL related #stroke
✅If #Notch3 expression by #pericytes is vital for stabilizing #endothelial #junctions, and #overexpressing #FGF2 prevents #aneurysm #dilation, would it be proactive to develop a dual Notch3/FGF2 therapy to #prevent wall dissection and subsequent aneurysm development?
✅If pericytes, during the #phenotype transition, express #SMC #contractile #markers such as #MYH11, #CALD1, and #SM22, could we consider these as early detection #biomarkers?
@AdvPhysiolEduc @ATHjournal @atvbahajournals @BISCRM @CardiologyPlus @CircHF @CircRes @DiabetesCareADA @DiabetologiaJnl @endothelialnews @FrontPhysiol @GizemEfePhD @gkolost @HaoYin20 @Ahmed43101178 @drshafikuchay @DKalodimou @LmnaCardiac @RCMjournal @TrackYourHeart @UCCS_HH @NatRevCardiol @NatureCVR @JCVPOnline @JCA_Journal @CNIC_CARDIO @APSPhysiology @The_MCSociety @ATH_Plus @isth @IEEEembs @IBMCP @TheIUPS @LuisSobrevia2 @CMPLPUCCHILE @FacMedicinaUC @SocFisiolChile @ALACFdifusion @escardio @ESC_Journals 👇🧵👇🧵
Two great teams out of Pitt have an insightful #ArticleinPress for you! Deficiency of Fibroblast Growth Factor 2 Promotes Contractile #Phenotype of Pericytes in Ascending #Thoracic Aortic Aneurysm (Weijian Huang et al. @UPMC_CTSurgery @PittEngineering):
https://t.co/Eu4ZqnDUBD
✅If #Notch3 expression by #pericytes is vital for stabilizing #endothelial #junctions, and #overexpressing #FGF2 prevents #aneurysm #dilation, would it be proactive to develop a dual Notch3/FGF2 therapy to #prevent wall dissection and subsequent aneurysm development?
✅If pericytes, during the #phenotype transition, express #SMC #contractile #markers such as #MYH11, #CALD1, and #SM22, could we consider these as early detection #biomarkers?
✅If creating agonist therapies targeting #ASH2L increases the risk of #tumor #promotion, could #AAV #gene #therapy #target other signaling components and thus prevent #vascular #remodeling and #PH progression?
✅By suppressing #KLF5 and #NOTCH3, could we actually generate an anti-remodeling effect, or are there other pathways yet to be elucidated?
✅Could these gene therapies have an anti-remodeling effect on #atherogenic processes focused on non-pulmonary #vessels, such as #coronary, #cerebral, and #systemic #vessels? 🫰🙏🙏😊🔬🐁🐁
@ATHjournal @atvbahajournals @CardiologyPlus @CircHF @DiabetesCareADA @HaoYin20 @gkolost
@StrokeAHA_ASA @Ahmed43101178 @drshafikuchay @RCMjournal @TrackYourHeart @IJMS_MDPI @IEEEembs @ManualOMedicine @WashUDeptMed @WashUCardiology @HyperAHA @CNIC_CARDIO @JCVPOnline @DCAcademyDK @NatRevCardiol @smexcardiologia @RevEspCardiol @SAC_54 @secardiologia @escardio @atherosociety @SocFisiolChile @FacMedicinaUC @LuisSobrevia2 @ALACFdifusion @isth @The_MCSociety @ESC_Journals 👇🧵👇🧵
Zhang & colleagues found #ASH2L exerts a protective role in #PH by promoting #KLF5 degradation via the #UPP, independent of H3K4 #methylation. Learn more about ASH2L in the pathogenesis of PH at https://t.co/ysL3stxc1s
#PublicaSalutIB @sonespases i @idisbaib han participat en un estudi on s'analitza com la variant NOTCH 3 afecta a CADASIL https://t.co/XrgDGLy5AP https://t.co/mulZ5bPiQr
#NOTCH3 #CADASIL #difusiócientífica #producciócientífica
#PublicaSalutIB @sonespases e @idisbaib han participado en un estudio donde se analiza cómo la variante NOTCH 3 afecta a CADASIL https://t.co/holrwaoSQb https://t.co/TLyM9tn3hA
#NOTCH3 #CADASIL #difusióncientífica #produccióncientífica
#PublicaSalutIB @sonespases i @idisbaib han participat en un estudi on s'analitza com la variant NOTCH 3 afecta a CADASIL https://t.co/jalpZZ6YV4 https://t.co/TLyM9tn3hA
#NOTCH3 #CADASIL #difusiócientífica #producciócientífica
Gain of function #NOTCH3 variants cause familial partial #lipodystrophy due to activation of #senescence pathways
https://t.co/hv6Z5Ymmmp
Check out new story on #GPC of biallelic #NOTCH3 mutations in #CADASIL and recessive small vessel disease! With @IruzubietaPablo @RMaroofian @alkuraya @WendyKChung @szuchner and many others!
Q6 @guto_montezano @LabTouyz
Would you please tell us a bit more about the methodology investigating the role of #Notch3 ?
#HYPHIP @HyperAHA @DrDudenbostel
Just published in Annals of Neurology @ANA_journals
We report a case of Medium/Large Artery Aneurysms in a patient with a #NOTCH3 heterozygous variant (c.1630C > T [p.Arg544Cys]) using whole genome sequencing with optical genome mapping.
@AndrewMakmur
https://t.co/8d5P1ZG8Ph
![DrBenjaminTan's tweet photo. Just published in Annals of Neurology @ANA_journals
We report a case of Medium/Large Artery Aneurysms in a patient with a #NOTCH3 heterozygous variant (c.1630C > T [p.Arg544Cys]) using whole genome sequencing with optical genome mapping.
@AndrewMakmur
https://t.co/8d5P1ZG8Ph https://t.co/oB9eJiZsLn](https://pbs.twimg.com/media/GPunog-bUAAP9Ja.jpg)
Last Seen Hashtags on Sotwe
Most Popular Users
Elon Musk 
@elonmusk
240.2M followers
Barack Obama
@barackobama
119.3M followers
Donald J. Trump
@realdonaldtrump
111.6M followers
Cristiano Ronaldo
@cristiano
109.3M followers
Narendra Modi
@narendramodi
106.9M followers
Rihanna
@rihanna
97.4M followers
NASA
@nasa
92.1M followers
Justin Bieber
@justinbieber
90.6M followers
KATY PERRY
@katyperry
87M followers
Taylor Swift
@taylorswift13
80.8M followers
Lady Gaga
@ladygaga
72.4M followers
Kim Kardashian
@kimkardashian
69.5M followers
Virat Kohli
@imvkohli
68.9M followers
YouTube
@youtube
68.6M followers
Bill Gates
@billgates
63.5M followers
The Ellen Show
@theellenshow
62.5M followers
CNN
@cnn
61.9M followers
Neymar Jr
@neymarjr
61.5M followers
X
@x
60.9M followers
Selena Gomez
@selenagomez
60.1M followers