Top Tweets for #endmt
#StressGranule #EndMT
In #EndothelialCell +H2O2
HDAC11 (similar to HDAC6/SIRT1/2) as a deactylase of G3BP1/2 (SG core proteins)➡️
⏫SG formation➡️
⏫EndMT in vitro
HDAC11 & G3BP1/2 appear⏫in🐭atherosclerotic lesions
#BBAMolCellRes 2025
https://t.co/WZzBpjCjH1
The last work from @ClarissaBecher thesis is published!💪 Hereby we show a new BMP/IL33 interplay in #rare pulmonary arterial hypertension, regulating #endothelial plasticity.
@Raras_CSIC @NanoCINN https://t.co/EK5i0gWPEH Check also the Editorial commentary! #PAH #CVD #EndMT
#HutchinsonGilfordProgeriaSyndrome
#SciArt
SM22α-Cre #SmoothMuscleCell-specific Progerin transgene (Lmna LCS/LCS) drives #EndMT #Atherosclerosis in 🐭+high fat diet
⏫Aortic Endothelial Cell permeability (Atto565-LDL i.v.)
⏫Leukocyte adhesion/extravasation
⏫Lesional EC infiltr▶️An intriguing ColIV-rich plaque😮
⏫Intimal Snail, Zeb2; ⏬intimal Twist1, Slug, Zeb1
⏫Aortic TGFβ1 (not TGFβ2), contributed by intraplaque mesenchymalized EC
What is the paracrine signal of progeroid aortic SMCs?😆
@CircAHA 2024
https://t.co/9ySYLFOX2d
Very proud to share our lab’s recently published work @ajpheartcirc
Early in my @NIH K08 on #EndMT, we found an interesting signal in COL8A1 in athero, w/ biphasic response to TNFa
🙏🏻 to ⭐️ postdoc Qian Li for leading us here (& @HaoYin20 for summary!)
https://t.co/Zc8xrpLErq
COL8A1 #EndMT
COL8A1
⬆️in Atherosclerotic endothelium
⏬by TNFα in 48 h, ⏫at 5 d
Human aortic endothelial cells with immobilized, but not soluble, COL8A1 proteins▶️
An elongated morphology
⏫Endothelial/angiogenic transcriptomic features
TNFα-induced #EndMT ⏫by siCOL8A1, ⏬by lentiviral COL8A1
@JeffHsuMD @ajpheartcirc 2025
https://t.co/mY2axMXXip
COL8A1 #EndMT
COL8A1
⬆️in Atherosclerotic endothelium
⏬by TNFα in 48 h, ⏫at 5 d
Human aortic endothelial cells with immobilized, but not soluble, COL8A1 proteins▶️
An elongated morphology
⏫Endothelial/angiogenic transcriptomic features
TNFα-induced #EndMT ⏫by siCOL8A1, ⏬by lentiviral COL8A1
@JeffHsuMD @ajpheartcirc 2025
https://t.co/mY2axMXXip
@LaenaPernomian et al demonstrate that OSK #TFs can promote reprogramming of #ECs & plays a protective role by preventing #EndMT & vascular remodeling elicited by #hypertension. More at https://t.co/c7NTBAW6FP
@CFWenceslau @CamGMcCarthy @Vini_Biancardi @AndrewVAAitken
🔬 Excited to share the publication "Endothelial Reprogramming in Atherosclerosis".
Welcome to access the full article freely here 👉 https://t.co/1oytyKIUk6
#atherosclerosis #endothelial_cell #reprogramming #EndMT #EndIT
Recent paper from our team investigating endothelial-to-mesenchymal transition in fetoplacental vasculature in pregnancies complicated by gestational diabetes #pregnancy #placenta #EndMT #reprorocks @UoL_LICAMM @LeedsPRG
https://t.co/jKQ2TYZ3dN
#SpatialTranscriptomics Human Embryonic Heart 8.4 9.7 pcw
Visium @10xGenomics
+snRNAseq
Contrast to vessel-nerve alignment, aortic valve leaflet is encircled but not invaded by nerve sprouts⬅️ 🧐Repulsive signals from #ValvularInterstitialCell #ValvularEndothelialCell (#EndMT)?
@Dev_journal 2025
https://t.co/UP6tP9efmn
If the effect of #BMP4 ligand is multifactorial, could the #EndMT #transition be prevented by blocking only the #PI3K/AKT/mTOR signaling pathway?....
Considering the synergy of BMP4 with #BGN, could we inhibit EndMT by decreasing BGN levels?
Are #CD31 and #FN1 #biomarkers for the early detection of #AAA? 🔬🫰😊🫰🐁🐁
@AHAScience @ATHjournal @atvbahajournals @society_eas
@AChCiencias @CMPLPUCCHILE @LuisSobrevia2 @atherosociety @CTRC_UofSCSOM @hopkinsheart @WashUCardiology @secardiologia @CNIC_CARDIO @JCVPOnline @DCAcademyDK @HaoYin20 @MetabolismAnd @Hiraselab_KU @PetrovaLab @vascularbiology @ESC_Journals @SocFisiolChile @ALACFdifusion @AsAshraf123321 @Ahmed43101178 @APSPhysiology
👇🧵👇🫰🫰
#EndothelialCell Robo4
👉⏬irradiation-induced #EndMT (Fn Col1a1 ACTA2 S100A4 VEcad CD31 Tie2 Cldn5)
👉Modulates #HematopoieticStemProgenitorCell quiescence & lineage potentials
Evidence from bEND3🐭microvascular EC
Look forward to in vivo data
Robo4-KD EC coculture▶️
HSPC cell cycle alteration (⏫G0 quiescence ⏫apoptosis)
⏫Ter119+ Erythrocyte
⏫CD41+ Megakaryocyte
(TBH, the flow cytometric data looks a bit confusing to me...🙃)
#CellDeathDis 2024 @cddpress
https://t.co/4wTzrFjLlr
Could inhibition of the #TGF-β and #Wnt/β-#catenin pathways be the #Precision #treatment of the future for controlling ##Endothelial-#mesenchymal transition #EndMT in #CVD and #cancer?
The great #ambivalence. Is #EndMT a cause or an effect? 🤔🔬🤔🐁🐁🔬
Could we control #EndMT by genetically editing #BRCA1/#BRCA2 with the #CRISP-#Cas9 technique?
@APSPhysiology @arasanz16 @AlisaAn46097029 @Ahmed43101178 @ATHjournal @ASH_hematology @AsAshraf123321 @atvbahajournals @BloodJournal @BMVBSoc @ChrStaehr @ClaireLeclech @CMPLPUCCHILE @LuisSobrevia2 @FacMedicinaUC @isth @EVB_Org @vascularbiology @VascularForum @makinenlab @CVIA_Journal @NatureCVR @secardiologia @CNIC_CARDIO @ESMicro_EU @society_eas @ESC_Journals @CMPLPUCCHILE @SocFisiolChile @TheIUPS @lipo_fan @endothelialnews 👇🧵👇
#EndothelialmesenchimalTransition
#Atherosclerosis #VascularCalcification #PeripheralArteryDisease #CardiacFibrosis #PumonaryHypertension
Endothelial-to-Mesenchymal Transition in Cardiovascular Pathophysiology
#EndMT
#Atherosclerosis
#VascularCalcification
#PeripheralArteryDisease
#PulmonaryHypertension
#ValvularHeartDisease
#MyocardialInfarction
#CardiacFibrosis
Krishna Singh lab @IJMS_MDPI 2024 @SchulichMedDent
https://t.co/VSNNIVfWJh
Could inhibition of the #TGF-β and #Wnt/β-#catenin pathways be the #Precision #treatment of the future for controlling ##Endothelial-#mesenchymal transition #EndMT in #CVD and #cancer?
The great #ambivalence. Is #EndMT a cause or an effect?
Could we control #EndMT by genetically editing #BRCA1/#BRCA2 with the #CRISP-#Cas9 technique?
Endothelial-to-Mesenchymal Transition in Cardiovascular Pathophysiology
#EndMT
#Atherosclerosis
#VascularCalcification
#PeripheralArteryDisease
#PulmonaryHypertension
#ValvularHeartDisease
#MyocardialInfarction
#CardiacFibrosis
Krishna Singh lab @IJMS_MDPI 2024 @SchulichMedDent
https://t.co/VSNNIVfWJh
Next up is Dr. Jason Fish, who just presented his exciting discovery of ERG as a gatekeeper of endothelial homeostasis against atherogenesis! Lineage tracing + multi-omics unveiled major impacts on modulating EndoMT in atherosclerosis
#EndMT #Aortopathy #MarfanSyndrome
A cascade of TGFβ-miR-632-DNAJB6 (#LimbGirdleMuscularDystrophy 1E)-βCatenin in both #EndothelialCell & #SmoothMuscleCell
miR-632 mimics delivery (lipofectamine) to cultured human aortic fragments
Amedeo Ferlosio & Augusto Orlandi labs @IJMS_MDPI 2023
https://t.co/kzl0hUqzj9
#EndMT in 3D (perfusable) Vascularized #SkeletalMuscleOnAChip
Further improving the muscle microphysiological system with Pericyte, Fibro-Adipogenic Progenitors & even immune cells
Do we have an isogenic #hiPSC-derived vascularized muscle model to study myopathy-vasculopathy (de)coupling in ischemia or dystrophy?😆
Simone Bersini lab Bioeng Transl Med 2024
https://t.co/yoGWIw00GW
Fresh in #CVR! @kovacic_jason team introduces a new large animal model for vein graft disease, highlighting the role of #EndMT in human pathologies. We were pleased to discuss their findings in our recent invited editorial @ClarissaBecher, @OUPAcademic. https://t.co/66yKfGVwaN
#EndothelialCell #Mitochondria #LimbIschemia #EndMT
Thrilled to have played a small role in this exciting story on EC #MitochondrialCalciumUniporter & #PeripheralArterialDisease 😁
Integrated single-cell RNA-seq analysis reveals mitochondrial calcium signaling as a modulator of endothelial-to-mesenchymal transition
Arteriolar ECs in👤amputated leg muscles lose their VE-cad junctions + #ApicalPolarity 🤓
Anna Rita Cantelmo lab @CantelmoRita @ScienceAdvances 2024
https://t.co/lsT6BQU2Xf
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