Top Tweets for #ezh2
Northwestern scientists found that #EZH2, a protein long recognized for its role in modifying DNA-packaging histones, also plays a direct and previously unknown role in #RNA editing in #ProstateCancer, per @NatureComms. https://t.co/Q0TaGdwkC0
New Epigenome Technologies Blog https://t.co/33gjL2a4mU
Does an Epigenetic Mechanism Provide a Novel Means of Improving Mesenchymal Stem Cell-based Therapies?
Based on a bioRxiv preprint from Lauren Monroe from the @theghoshlab
#Epigenetics #Blog #EZH2 #MSCs
Epigenetics Update - The conserved N-terminal SANT1-binding domain (SBD) of EZH2 regulates PRC2 activity https://t.co/odArBIeNtB
Agata L. Patriotis (Rockefeller Uni) in Genes Dev
#Epigenetics #EZH2 #PRC2
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Perfect for cancer, immunology, and aging; https://t.co/WmSYDGWPJD
Epigenetics Update - EZH2 directs HER2+ breast cancer progression through the modulation of epithelial plasticity https://t.co/goNUNlECNK
William J Muller in EMBO Rep
#Epigenetics #EZH2 #BreastCancer
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Perfect for cancer, immunology, and aging; https://t.co/WmSYDGXnzb
@yu_jindan Thrilled to share our latest #research on #EZH2 "EZH2 PROTACs outperform catalytic inhibitors in prostate cancer by targeting a methylation-independent function of PRC2" now published in @oncogenejournal with @SpringerNature (https://t.co/2l62B2z26G).
RESEARCH PAPER: Dominant-negative effects of Weaver syndrome-associated EZH2 variants
By Deevy et al., Eric Conway and Adrian Bracken @conwayer1 @adrianbracken
➡️ https://t.co/UbX2WIap4q
#weaversyndrome #ezh2 #polycomb #mutation #epigenetics #congenitaldisorder #onthecover
Thank you to everyone at the University of Miami. Enjoyed meeting everyone and presenting the labs work on #EZH2 #ProstateCancer #Plasticity #SpatialEpigenomics
Epigenetics News - Study Finds Restoring Order to Dividing Cancer Cells May Prevent Metastasis https://t.co/7tYUW4xpYc
#Epigenetics #News #TNBC #EZH2 #Cancer
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Perfect for cancer, immunology, and aging research; https://t.co/WmSYDGWPJD
Article✍️#Deubiquitinase #OTUD6A alleviates #acetaminophen-induced liver injury by targeting #EZH2 to reduce cell death in #hepatocytes. From Dr. Wang @WenzhouMedicalUniversity;
https://t.co/8xq5nc5lzj.
Ellagic acid acts as a potent EZH2 inhibitor, with promising anti-cancer Activity
https://t.co/HSCxBkVXgw
#Epigenetics #EZH2 #Breastcancer
Ellagic acid blocks EZH2, lowers the cancer mark H3K27me3, triggers tumor-cell death in a breast cancer mouse model. Early but promising epigenetic angle. #Epigenetics #EZH2 #BreastCancer
https://t.co/WszYbWe6Ki
@Kirankumar0014
@BeatrizGerFalc summarizing some of her latest work with the lab. #EZH2 controls cell plasticity in #ProstateCancer through coordination with activation of #translation and the RNA degrading protein #tristetraprolin @CPDR_Labs
Targeting lineage plasticity in #ProstateCancer with EZH2 inhibitor mevrometostat. @MikeSchweizerMD @fredhutch sits down with Oliver Sartor, MD @MayoClinic diving into #mevrometostat—an #EZH2 inhibitor tackling lineage plasticity in #mCRPC. Adding it to enzalutamide slashed progression risk by 49% (PFS: 6→14mo)! 🍽️ Food effect study = fewer side effects. Phase III trials incoming! 🔬🔥 #WatchNow > https://t.co/n2WyxLUYyZ
Targeting lineage plasticity in #ProstateCancer with EZH2 inhibitor mevrometostat. @MikeSchweizerMD @fredhutch sits down with Oliver Sartor, MD @MayoClinic diving into #mevrometostat—an #EZH2 inhibitor tackling lineage plasticity in #mCRPC. Adding it to enzalutamide slashed progression risk by 49% (PFS: 6→14mo)! 🍽️ Food effect study = fewer side effects. Phase III trials incoming! 🔬🔥 #WatchNow > https://t.co/n2WyxLUYyZ
Targeting lineage plasticity in #ProstateCancer with EZH2 inhibitor mevrometostat. @MikeSchweizerMD @fredhutch sits down with Oliver Sartor, MD @MayoClinic diving into #mevrometostat—an #EZH2 inhibitor tackling lineage plasticity in #mCRPC. Adding it to enzalutamide slashed progression risk by 49% (PFS: 6→14mo)! 🍽️ Food effect study = fewer side effects. Phase III trials incoming! 🔬🔥 #WatchNow > https://t.co/n2WyxLUYyZ
Targeting lineage plasticity in #ProstateCancer with EZH2 inhibitor mevrometostat. @MikeSchweizerMD @fredhutch sits down with Oliver Sartor, MD @MayoClinic diving into #mevrometostat—an #EZH2 inhibitor tackling lineage plasticity in #mCRPC. Adding it to enzalutamide slashed progression risk by 49% (PFS: 6→14mo)! 🍽️ Food effect study = fewer side effects. Phase III trials incoming! 🔬🔥 #WatchNow > https://t.co/n2WyxLUYyZ
I'll never forget that 2015 paper @decarvalho_lab
Changed what we started to look for downstream of epigenetic therapy (for us - #ProstateCancer and #EZH2
https://t.co/MUI6xlZMlQ
🌟“Surprise is always the strongest signal that you found something new.”
Research from @GairdnerAwards awardee @decarvalho_lab is unlocking powerful new tools impacting cancer clinical care, from interception, detection to therapy design and monitoring.
https://t.co/hgoXQDtPSR
Targeting lineage plasticity in #ProstateCancer with EZH2 inhibitor mevrometostat. @MikeSchweizerMD @fredhutch sits down with Oliver Sartor, MD @MayoClinic diving into #mevrometostat—an #EZH2 inhibitor tackling lineage plasticity in #mCRPC. Adding it to enzalutamide slashed progression risk by 49% (PFS: 6→14mo)! 🍽️ Food effect study = fewer side effects. Phase III trials incoming! 🔬🔥 #WatchNow > https://t.co/n2WyxLUYyZ
@OncoAlert Last is phase II trial of enzalutamide +/- #EZH2 inhibitor mevrometostat from @pfizer for #mCRPC after abiraterone progression. Improved PFS with combo but added GI tox. Phase III trial underway. @OncoAlert #GU25
#ezh2 inhibition with #mevrometostat in #mCRPC showed improved rPFS in a phase 2 trial with some GI side effects but side effects lower at lower dose with food. Phase 3 trials underway.
Happy to share the publication of our last work describing the safety and efficacy of #BRD4 and #EZH2 dual targeting in preclinical models of EZH2Y641mut B-cell lymphoma @roue_s @CarrerasIJC https://t.co/lM3aLDXiA9
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