Top Tweets for #her3
FOxTROT had a twist: in locally advanced RAS/BRAF-wt colon cancer, HER2 didn’t predict EGFR benefit…but HER3 + EGFR ligands did.
Early-stage EGFR biology may need biomarkers of inclusion—not just exclusion.
#CRC #EGFR #HER3 #Biomarkers #ASCOGI
🇨🇳 DualityBio announced that FDA has granted Fast Track Designation (FTD) to its next-generation #HER3-targeting #ADC DB-1310. This designation is for the treatment of adult patients with advanced, unresectable or metastatic nonsquamous non-small cell lung cancer (nsqNSCLC) with an EGFR exon 19 deletion or L858R mutation with disease progression on or after treatment with a third-generation EGFR tyrosine kinase inhibitor (TKI) and platinum-based chemotherapy. https://t.co/11zLkie97z
HER3-Targeted Antibody-Drug Conjugate Shows Promise for Treatment-Resistant Solid Tumors
@UCLAHealth @UCLAHealthJCCC @ASCO @ErikaHamilton9
https://t.co/C5F8yffNES
#OncoDaily #Oncology #Cancer #Health #Medicine #MedTwitter #MedEd #MedOnc #MedNews #ADC #HER3 #SolidTumors #NSCLC #LungCancer #DB1310 #ASCO #ASCO2025 @CancerWorldmag
🔥🚨@OncoAlert Hot off the press.
Disappointing (but understandable) news.
#Patritumab Deruxtecan (#HER3-DXd)
application for #FDA approval in advanced #EGFR+ non-small cell #LungCancer is withdrawn.
Withdrawal is based on results from #HERTHENA-Lung02 Phase 3 trial where OverallSurvival (#OS) did not meet statistical significance.
Results will be presented @ASCO #ASCO25
👇🏻
https://t.co/icvgWGMcHX
🇨🇳 #ASCO2025 #DualityBio reported preliminary results form Ph1/2a trial of #DB1310, a #HER3-targeted #ADC, in pts with advanced solid tumors. https://t.co/ML8gdUR6cz
DB-1310 is a novel ADC comprised of a humanized anti-HER3 IgG1 monoclonal antibody, cleavable peptide linker, and DNA topoisomerase I inhibitor.
The unconfirmed ORR was 25.5% (95% CI, 17.63, 34.65) across all tumor types and 35.7% (95% CI, 21.55, 51.97) in EGFRm NSCLC. Median PFS was 5.4 months overall and 7.0 months for EGFRm NSCLC.
ADCs in #NSCLC: From HER2 exon 20 insertions to #TROP2 and #HER3 targets, new #ADCs offer promise across mutation-driven and refractory settings. Drs Patel & Singhi break down the evolving biomarker landscape. https://t.co/DBHJfZHInq #LungCancer @PatelOncology @lungoncdoc
✨Exciting News! A new study showcases the efficient discovery of cell-binding miniproteins for #HER3, a key tumor marker, using combined computational and phage display techniques for potential theragnostic applications
#CancerResearch #ProteinEngineering #Biotechnology
ADCs in #NSCLC: From HER2 exon 20 insertions to #TROP2 and #HER3 targets, new #ADCs offer promise across mutation-driven and refractory settings. Drs Patel & Singhi break down the evolving biomarker landscape. https://t.co/DBHJfZHInq #LungCancer @PatelOncology @lungoncdoc
1/ 🧬 HER3 lacks strong kinase activity...
But it's a powerful oncogenic driver.
📈 Overexpressed across many tumors
💥 Implicated in drug resistance
🔗 Now officially targetable in NRG1 fusion cancers
#Oncology #HER3 #TargetedTherapy
https://t.co/1xdPEOWJYi
Great discussion between @DrRosenbergMSK and @CaPsurvivorship on promising new targets and therapeutics including BL-B01D1 #urothelialcancer #bladdercancer #her3
Innovative therapies in GU cancers: Promising targets in #Urothelial and #Kidney cancer. @DrRosenbergMSK @MSKCancerCenter joins @CaPsurvivorship @DanaFarber to discuss:
- BL-B01D1: A bispecific ADC (EGFR/HER3) with a 40% response rate in advanced urothelial cancer.
- NKT2152: A HIF2a inhibitor for RCC, showing promise but with toxicity challenges.
They explore combinations & sequencing to refine GU cancer care.
#WatchNow > https://t.co/HF5NPuInPv
A basket study evaluated the efficacy of zenocutuzumab, a bispecific antibody against HER2 and HER3, in patients with solid tumors harboring NRG1 fusions. Among 158 patients, 30% had a response (including 42% with pancreatic cancer).
Full eNRGy study results: https://t.co/3IF5tJFeAl
Excited to be speaking at @consensus_hk on "Accelerating Agricultural Sustainability: Leveraging Blockchain and AI."
These advancements strengthen @dimitratech's ecosystem, creating new opportunities for $DMTR and its vital role in our mission. #Her3 @CoinDesk and #ConsensusHK.
These insights contribute to the growing body of evidence on the potential role of biomarker-driven optimized treatment strategies with antibody-drug conjugates like T-DXd and HER3-DXd. 💡
#ABCSGbefirst #BreastCancer #CancerResearch #ClinicalTrials #Oncology #HER2 #HER3 #ADCs
ICYMI in @CD_AACR following yesterday's accelerated FDA approval: Zenocutuzumab, a #HER2 x #HER3 #Bispecific Antibody, Is Effective Therapy for Tumors Driven by #NRG1 Gene Rearrangements - by @AliSchram and colleagues @MSKCancerCenter
Read the related article: https://t.co/8fztPzt7gO
Drs. Stephen V. Liu (@StephenVLiu) and Melissa L. Johnson (@MLJohnsonMD2) along with Prof. David Planchard (@dplanchard) provide guidance on updating the #LungCancer treatment algorithm with novel #ADCs. https://t.co/TcY1qccNmm #NSCLC #HER2 #HER3 #TROP2 #SCLC
TESTEZ VOS CONNAISSANCES SUR RENNES 🧐
Répondez dès maintenant à notre énigme et découvrez la réponse en commentaire ! 🕵️♀️
📖 Le livre est disponible en prévente ici : https://t.co/OOkPn2Ivay
#leshistoiresextraordinairesderennes #mystèresdeRennes #littérature #histoire #HER3
FYI #MedTwitter #OncTwitter #lcsm
I am leading a course called “Unlocking the Potential of Breakthroughs in #NSCLC Therapeutic Approaches” that offers CME/CE credit. Would love to have you! You can learn more and sign up at:
https://t.co/vXMjsIEqIH
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