Top Tweets for #keap1
Congratulations to @DiFedericoMD on receiving the @IASLC Educational Award and to @CMHidalgoFilho on being selected for the @IASLC Academy! Very well deserved.
Even more exciting to see them both presenting our work on #BRAF class II/III alterations and #STK11/#KEAP1 in RAS-dependent NSCLC at #WCLC26. #LCSM
@ChristianRolfo @g_mountzios @marinagarassino @DanaFarberNews @BalazsHalmosMD @NarjustFlorezMD
At #ASCO26, the @UTMDAnderson Thoracic Medical Oncology Department will deliver an incredible 9 oral presentations💐💐💐 highlighting advances across ##EGFR, #HER2, #KRAS, #KEAP1/STK11, #SCLC, IO, #peri-operative, all lung cancer subgroups. For perspective, thoracic medical oncologists from China have 16 oral presentations.
👩⚕️🧑⚕️ 👩🔬🧑🔬Our entire MDA Thoracic team @FSkoulidis @NIVokes @LaurenByersMD @lungoncdoc Drs. Heymach, Cascone, Zhang, @mvnegrao @YYElamin @AnneTsao2 are deeply proud and excited 😀to help shape the future of lung cancer research and patient care alongside outstanding collaborators and industry partners.
Article✍️#Chemical #knockdown of #Keap1 and #homoPROTAC-ing allergic #rhinitis. From Dr. Zhuang @NavalMedicalUniversity;
https://t.co/GVdy5j4EYN.
@DiFedericoMD @TumorBoardTues @BiagioRicciutMD @IntegrityCE @alessi_joao @pecci_federica1 @RobertoFerrara_ @NarjustFlorezMD @MarceloCorassa @DrMarkAwad @StephenVLiu @BalazsHalmosMD @PTarantinoMD @EdoardoGarbo @FSkoulidis @FawziAbuRous @ADesaiMD @thenasheffect @ACortelliniMD @ChristianRolfo @ABarsouk @Alfdoc2 @lungoncdoc @JackWestMD @marinagarassino 14/20 | #TumorBoardTuesday
2. Does adding #CTLA-4 inhibition to PD-(L)1i + chemotherapy improve outcomes in #STK11/#KEAP1-mutant #NSCLC?
Retrospective and preclinical data say it might, but…
📢🚨Excited to share our latest paper from the #SenLab, now out in @CR_AACR!
We uncover a #metabolic vulnerability in #KRAS/#STK11/#KEAP1 co-mutant #NSCLC—a highly aggressive and treatment-refractory form of #lungcancer.
Our study uncovers how lipid desaturase SCD1 sustains redox balance and enables ferroptosis evasion in this subset. These insights highlight a therapeutic opportunity and underscore the need for #precisionmedicine to consider the metabolic rewiring of #lungcancer subtypes.
Data breakdown coming soon in a 🧵
Huge thanks to the incredible Sen Lab team (especially @UtsavSen10), and amazing collaborators at @IcahnMountSinai, @carisls, and beyond. Grateful to @theNCI and @CDMRP for funding this work.
@IcahnMountSinai @TischCancer @IASLC @lcrf_org @lcfamerica @oncodaily @OncLive @lcsmchat @KRASKickers
#LungCancer #NSCLC #CancerResearch #KRAS #SCD1 #Ferroptosis #CancerMetabolism #PrecisionOncology #TargetedTherapy #MetabolicVulnerabilities #RedoxBiology #TranslationalResearch #OncoTwitter #TeamScience #NewTherapeutics #DrugDevelopment #Ferroptosis
Link: https://t.co/BMNGaB4vao
Scientists have identified how the redox sensor #KEAP1 promotes antiviral T cell activation and stem-like T cell responses during chronic viral infections in mice.
Read more in @SciImmunology: https://t.co/xZ1aKNFuYu
Scientists have identified how the redox sensor #KEAP1 promotes antiviral T cell activation and stem-like T cell responses during chronic viral infections in mice.
Read more in @SciImmunology: https://t.co/xZ1aKNFuYu
A new Science #Immunology study describes how the #KEAP1-mediated inhibition of #NRF2 limits TCR hyperactivation and facilitates long term T cell immunity during persistent viral infections in mice. https://t.co/AGWrKcxitG
Scientists have identified how the redox sensor #KEAP1 promotes antiviral T cell activation and stem-like T cell responses during chronic viral infections in mice. @utswimmuno @lab_yao
Read more in Science #Immunology: https://t.co/AGWrKcxitG
It was a lot of fun to writhe the preview perspective article: “A Double Whammy for KEAP1”.
Discover the bivalent mechanism affecting KEAP1 and their implications for future small molecules.
#FirstPaperFromTheLab #Science #KEAP1 #Biology #NewPublication
https://t.co/nNQIepjyCV
It was a lot of fun to writhe the preview perspective article: “A Double Whammy for KEAP1”.
Discover the bivalent mechanism affecting KEAP1 and their implications for future small molecules.
#FirstPaperFromTheLab #Science #KEAP1 #Biology #NewPublication
https://t.co/nNQIepjyCV
Read the Editorial: Induced proximity in biology and therapeutics, learn more about #PROTACs #RNATACs #Therapeutics #Velcrins #Wnt #KEAP1 #MolecularGlues #Bifunctional #PPI #Epigenetics #glycoRNA #photocatalytic #TPD #LyTACs https://t.co/jXQ0dF7JHX
We hope you can attend the next @WCMCPathology Cell and Cancer #Pathobiology Seminar Faculty Presentation, “Elucidating the role of the tumor suppressor #KEAP1 in antitumor immunity,” by Dr. @_AntonioMarzio , Ass't Prof of #Pathology and Lab. Med.
May 23rd at 11am, room C-405
#SenLab focuses on the advancement of #therapies for #lungcancer.
🚨Work led by @UtsavSen10 on #KRAS/#STK11/#KEAP1 co-mutant #lungcancer is being presented at #AACR24. Stop by his poster later today to learn more about the biology of these #tumors.
@IcahnMountSinai @KRASKickers
From @triparnasen at #AACR2024: SCD1 upregulation due to STK11/KEAP1 loss upregulates SLC7A11 and causes deregulation of fatty acid metabolism leading to ferroptosis evasion
https://t.co/Ta5lgaft6s April 7, 1:30-5 pm, Section 26
@IcahnMountSinai #lungcancer
Proud to see our figure 1 on KEAP1/NFE2L2 transcription signatures made it to the cover of @JTOonline current issue. #LCSM #KEAP1
Presenting @asco #2023 #DrLeeKrug from @astrazeneca their #POSEIDAN data in the industry theatre. Certain biomarkers affect #immuno response. #Pdl1 #kras #stk11 #keap1 #lungcancer
#OpenAccess
Advances and challenges in therapeutic targeting of NRF2
https://t.co/TNbp57Zp1D
@UoDMedicine
Prof Albena Dinkova-Kostova @Copple_lab
#NRF2 #KEAP1 #Electrophile #OxidativeStress #Inflammation #ChronicDisease
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