Top Tweets for #tightjunction
Our own @RanaAlSadi2 presented at GI Grand Rounds yesterday on an exciting topic — tight junction barrier in IBD. 🧬🔬💩
Learn more about her work: https://t.co/5rLNWZA75n
#IBD #tightjunction #microbiome
#Pericyte #BloodBrainBarrier
Induced Pdgfrb+ Pericyte ITGA8 KO🐭
Baseline by 40 d
⏬microvascular pericytic coverage
⏬#EndothelialCell #TightJunction
⏫#VascularPermeability 70kD/2M dextran
⏬EC-Pericyte N-cad junction
⏬Homer1+ Bassoon+ Synapse
⏬dendritic spine (in both motor cortex & CA1)
⏫Fluoro-Jade B+ degenerated neurons
⏫Neurobehavioral anomalies (gait, motor learning, spatial memory, recall)
Stroke by 7d
Similar defects observed for endothelial junctions, barrier, pericyte coverage & neurological functions
ITGA8 overexpression➡️RhoA-ROCK-pMLC2➡️ Elongated, Arborized morphology of cultured pericytes
Intriguingly, pericytic ITGA8 likely activates TGFβ1 secreted by EC (not pericyte)
#AdvSci 2025 @AdvPortfolio
https://t.co/4ALQS3m628
Exploring the Critical Role of Tight Junction Proteins in #Kidney Disease #Pathogenesis
🔗https://t.co/Of0tOLRAn9
✍ Jayne D. et al.
📖#Nephron
#TightJunction #Fibrosis
Our study on the mechanism that enables rapid formation of the epithelial barrier has been officially published as a Version of Record in eLife!
Article: https://t.co/OrbhU4Ul5o
#barrierfunction #LifeScience #Tightjunction
Cellular #Senescence & Compromised #TightJunction in #SubmandibularGland in��Natural #Aging (18-mo) or D-galactose (for 8 wk)
Interestingly, SA β-Gal activity was only evident in aged SMG, not parotid or sublingual glands.
Even if aged parotid gland also exhibits acinar atrophy, lipid accumulation, periductal fibrosis & even higher inflammatory cell infiltration.
@Aging_Cell 2025
https://t.co/AGtaiOuVFI
#TightJunction maintains epithelial cell #Lumenogenesis via keeping Apical Junctional Tension at bay, Independent of Barrier functions👹
Common & Distinct morphometrics & mechanics (hydrostatic pressure, junctional tension) of ZO1/2 KO vs Claudin quin-KO MDCK-II cyst in Matrigel
Y27632 ROCKi⏫lumen volume/occupancy in both ZO- & CLDN-KO, but not WT cysts (Guess Blebbistatin may have similar effects?😁)
Super-Cool skills to deflate & inflate individual lumens! (2P laser cutting, micropipetting)🤠
@MarkusMukenhirn @RivelineLab @Honigmann_Lab @Dev_Cell 2024
https://t.co/e8iOIhehI9
#EndothalialCell #TightJunction #AorticDissection
In👤#ThoracicAorticDissection, tight junctions loosen (Multi-Transcripts⏬)
In🐭BAPN1⃣Thoracic aortic endothelial permeability⏫at day 5, before any macroscopic dissection
2⃣Aortic VE-cadherin junctions remain unaltered
3⃣AT-1001, a PAR2 inhibitor, reseals ZO-1 TJ, ⏬aortic permeability (70 kD), ⏬incidence of dissection by >50%
4⃣EC ZO-1 KO⏫dissection🤓
#AortaEd
#EHJ 2023 @ESC_Journals
https://t.co/5x30ruc0hT
Loss of Lamininα5 from Both Tie2+ #EndothelialCell & PDGFRβ+ #Pericyte compromises #BloodBrainBarrier #BBB
Intact #TightJunction
Intact AQP4+ Astrocyte endfeet
⏫#Transcytosis ⏫Cav1 ⏬MFSD2A
⏬🧠pericyte
Despite unaltered microvessel density/branching, Lama5 mutant seems to have⏫interindividual variability
Any impact on neuroinflamm/behav?
Yao Yao lab Fluids Barriers CNS 2024
https://t.co/fbwiZ7mPFy
TMEM25 is a Par3-binding protein that attenuates #claudin assembly during #tightjunction #development.
-> https://t.co/DTI6lI4ZZx
Let's Stick Together: How tight junctions – leak-proof interactions of protein complexes – between #epithelial #cells are regulated. Image & research by Sachiko Kamakura et al @KyushuUniv_EN in @emboreports. On https://t.co/pqgf9uqUmB
Structure-function analysis of tight junction-directed permeation enhancer PIP250.
| Randall J. Mrsny @UniofBath | @UKICRS
[50 days' free access]
#CellPenetratingPeptide #enhancer #tightjunction
https://t.co/lMfyHdzasW
![JCRnEDITORS's tweet photo. Structure-function analysis of tight junction-directed permeation enhancer PIP250.
| Randall J. Mrsny @UniofBath | @UKICRS
[50 days' free access]
#CellPenetratingPeptide #enhancer #tightjunction
https://t.co/lMfyHdzasW https://t.co/C6loICfTIk](https://pbs.twimg.com/media/F-4nHYhakAAgRuf.jpg)
Pathology International Early View
編集長です。札幌医大からの総説です。
タイトジャンクションによる癌の制御に関するとてもわかりやすいレビューです！図も美しい！
#pathology #tightjunction #claudin #occludin #cancer
https://t.co/w95E9ZBKej
Pathology International Early View
Hello, editor-in-chief. Thank you for the review article from Sapporo Medical Univ in Japan. Comprehensive review for cancer and tight junction with beautiful figures!
#pathology #tightjunction #claudin #occludin #cancer
https://t.co/w95E9ZBKej
Paper published in @Cells_MDPI (ISSN 2073-4409) discusses new insights into the mechanisms by which probiotics are able to prevent damage to the gut epithelial barrier. #IntestinalEpithelialBarrier #TightJunction
Access the paper: https://t.co/1gCySPzmkQ
@PatientPersists butyrate #teambutyrate & akkermansia #tightjunction to support mucosal immunity which is central and prevent microbial translocation (microclots) @resiapretorius
@MolmansTom @Bradgolf1216 Mucosa immunity play a central role in the disease, until we do not understand it, we will not treat in a relevant way and fail to prevent new case ... #barrier #mucosalimmunity #gut #epithelium #tightjunction #microclots #vagusnerve
As always, beautiful Rho flares from Dr. Ann Miller's lab imaged in one of my favorite models, Xenopus laevis. They identify a #RhoGEF that activates these flares at sites of #TightJunction breaks!
📃 State-of-the-Art Review
Junctional complexes in epithelial cells: sentinels for extracellular insults and intracellular homeostasis
✒️ By Huimin Zhang and colleagues
🔗 https://t.co/34OUvEuKQq
#adherensjunction #tightjunction #autophagy #epithelium #innateimmunity
Newly-established in vitro inner BRB spheroids to elucidate retinal Ang2-linked substance transfer.
| Ken-ichi Hosoya @univ_toyama |
#spheroid #bloodretinalbarrier #transporter #tightjunction
https://t.co/iesDX64jo1
Excellent presentations from my amazing team ThomasMalab #tightjunction #DDW2022 #gastrosquad @AmerGastroAssn
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