Top Tweets for #usp7
The Gersch Group developed a well characterized matched chemical pair of inhibitor and degrader for the investigation of the #DUB #USP7 in #solidcancers together with the Cancer Center at the @UniklinikEssen Congrats to @NikolasKlink et al.!
https://t.co/K6HPyouvpX
#Molecure in collaboration with #MedicalUniversityOfWarsaw and #JagiellonianUniversity explores targeting ubiquitin-specific protease 7 (#USP7)
Read more➡️https://t.co/m9NRmRD3BO
#MedChem #p53 #MDM2 #DrugDiscovery #Biotech #CancerResearch #HematologicMalignancies #BCellLymphoma
Happy to share our ACS Omega paper on USP7: structure-based pharmacophore-guided repurposing + docking/MD/MM-GBSA reveal promising inhibitors. https://t.co/4a78wauA57 #USP7 #ACSOmega #CompChem #DurdagiLab
Excited to share our latest research on the discovery of promising #USP7 inhibitors! USP7 is a de-ubiquitinating enzyme and a highly therapeutic target for many types of cancer. Grateful to my colleagues for their inspiring teamwork and for Dr. Durdagi's support and mentorship
Our pharmacophore-guided USP7 drug repurposing + physics-based simulation study has been accepted in ACS Omega!
We are pleased to announce that Molecure has been granted its first patent (US12404279 (B2)) covering a novel series of #USP7 inhibitors 💡 This achievement highlights the originality of our science and our mission to deliver first-in-class small molecule therapies for patients🔬
✅If blocking the #USP7-PDK1-AKT/NF-κB axis #inhibits #vascular #inflammatory response, increased permeability, and immune cell migration/adhesion in #pulmonary #vessels, would this option be truly effective in other vascular pathologies such as cerebral edema, #anaphylaxis, #renal #edema, and #cardiovascular #disease?
✅Considering that USP7 mediates angiogenesis through the #Sp1/Sp3 #Notch1 #pathway in response to #ACE #inhibitors, could we infer that ACE inhibitors would have an #antiangiogenic effect in the #tumor #microenvironment?
@AdvPhysiolEduc @ATHjournal @atvbahajournals @BrisaPenaUCD @CardiologyPlus @CircHF @CircRes
@DiabetesCareADA @DiabetologiaJnl @endothelialnews @FrontPhysiol @gkolost @HaoYin20 @WashUCardiology @WashUDeptMed @IEEEembs @StrokeAHA_ASA @HPE_ORG @LungCancerEu @NatureRevCancer @Cancer_Cell @JCA_Journal @RCMjournal @CMPLPUCCHILE @LuisSobrevia2 @FacMedicinaUC @JCVPOnline @CNIC_CARDIO @NatureCVR @Ahmed43101178 @Ahmedata7777 @ALACFdifusion @TheIUPS @SocFisiolChile @RockUPress @The_MCSociety @DKalodimou @SVINJournal @DCAcademyDK 👇🧵👇🧵🧵
This research out of Nanchang University demonstrates the role of a novel USP7-PDK1 signaling axis in regulating TNF-α-induced vascular #EndothelialInjury.
Findings in @cddpress reveal that USP7 is a deubiquitylating enzyme of PDK1.
🔓: https://t.co/MIAIb0mQxa
Our latest research has been accepted at the ChemMedChem! #DrugDiscovery #CancerResearch #USP7 #ComputationalBiology #VirtualScreening #DurdağıLab #HITMER #DURDAi https://t.co/YcPmHOJy6T
We can’t thank our researchers enough! We love you! @TTUVetMed @klementinafontacer #RareDiseaseDay2025 #haofountainsyndrome #RareDiseaseDay #usp7
Very happy to share our new collaborative paper describing a key role for USP7-PRC1.1 in neural differentiation, now in @GenesDev
And congratulations to the PhD student, Axelle, on her 1st research paper.
#USP7 #epigenetics #neural @FoundationUSP7
https://t.co/9oLl8wLzJr
new international collaborative work incl our group on Hao-Fountain syndrome and the mechanisms underlying USP7 published in Genes & Development
#raredisease #USP7 #epigenetics #drosophila #neurons @JeffreyHaren @YAtlasi, Peter Verrijzer, @druoph @FoundationUSP7 @ErasmusMC
On Sept 24, we are hosting the Hao-Fountain Syndrome Symposium & Family Conference in Atlanta and have sponsorship opportunities available. This event brings together leading researchers & families affected by Hao-Fountain Syndrome. Questions? Email [email protected] #usp7 #hafous
USP7-Based Deubiquitinase-Targeting Chimeras Stabilize AMPK | Journal of the American Chemical Society @BIDMChealth @MountSinaiNYC
@MountSinai @IcahnMountSinai #USP7 #Deubiquitinaase #Chimeras #Satbilization #AMPK https://t.co/3cpFk1JJ8i
In honor of our Hao-Fountain Syndrome Awareness Day, we will be sharing facts at throughout the day across all our social media platforms. Stay tuned to our feed, and please, share our posts, engage with our content, and help us spread the word. #haofountainsyndrome #usp7
We are honored to welcome you to Rare Disease Day where we shine a light on those affected by Hao-Fountain Syndrome. Today, we celebrate our fighters, our families, and the incredible work being done to support and uplift those impacted by this condition. #usp7 #rarediseaseday
Tess Army: we learned a TON from Dr. Schaaf’s phenotyping study. 🔥 Check it out and please RT. #USP7 #HaoFountainSyndrome
New insight on Hao-Fountain syndrome: clinical severity score, genotype-phenotype correlations and expansion of phenotypic spectrum. @FoundationUSP7 @bcmgenetics @bcmhouston @UniHeidelberg @uniklinik_hd
https://t.co/iFlQMvY15B
I'm running the Houston Marathon on 1/14 with Olivier Emmenecker, whose daughter Zoe is Tess's USP7 sister over in France. Please donate today. Thank you! https://t.co/Uz4VpiEURQ #USP7 #HaoFountainSyndrome #runhou #runhouston
Check out this new research publication from Hao Chen & Albert Kim, MD, PhD about #USP7 and #HaoFountainSyndrome! "Novel p53-independent ubiquitin signaling pathway."
https://t.co/LHcVAtQyAR
@AlbertHKimMDPhD
@WUSTLmed
@FoundationUSP7
Thrilled about this preprint article from Hao Chen & Albert Kim, MD, PhD about USP7 and Hao-Fountain syndrome! You guys had me at "a novel p53-independent ubiquitin signaling pathway." https://t.co/yxXspKNYrw @AlbertHKimMDPhD @WUSTLmed #USP7 #HaoFountainsyndrome @FoundationUSP7
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