Hege Røsåsen

Creator of Semeiré - The psilhouette bouquet

[Hege Røsåsen @hrosasen]

@Kristoffarnora *Knis*

[Hege Røsåsen @hrosasen]

@aage_no Mange år siden bildet ble tatt

[Bryan Johnson @bryan_johnson]

Three exciting longevity results came back from my first dose of mushrooms: >35% decrease in inflammation, a deeply relaxed state and neuroprotective effects.

Inflammation (hsCRP)
My systematic inflammation levels dropped from elite to undetectable. This decrease is significant, aligning with clinical reports of reduced inflammation markers (CRP, TNF-alpha, and IL6) seven days post high dose psilocybin.

+ pre-mushrooms: 0.23mg/dL
+ post-mushrooms: < detection limit 0.15mg/dL
+ >35% decrease

Deep low stress state (HPA Axis)
My cortisol and DHEA-S dropped by 42% and 45%, respectively, suggesting a profound inhibition of the Hypothalamus-Pituitary-Adrenal (HPA) axis, which corresponds with the "after-glow" effect.

+ DHEA-S: 287µg/dL to 157 µg/dL
+ morning cortisol: 10.3 µg/dL to 5.9 µg/dL

While cortisol spikes acutely during the trip, the post-session drop indicates a shift from sympathetic to parasympathetic dominance. This aligns with my sustained relaxed and joyful state.

Neuroprotection (Estradiol)
Estradiol increased 3x (11.3 to 36 pg/ml). This may be due to peripheral activation of 5HT2A receptors stimulating aromatase activity, the enzyme that converts testosterone to estradiol.

A study has shown 5HT2A stimulation in human placental cells can drive aromatase gene expression and activity. My testosterone levels remained unchanged, indicating my body compensated for the minor conversion to estradiol.

The increase is within the normal male range and is generally positive, as estradiol provides anti-inflammatory, neuroprotective and cardiovascular protective effects.

Conclusion
Taken together, these data suggest that a single high dose psilocybin experience can transiently push my biology into a low inflammation, low stress configuration that is theoretically favorable for longevity.

Measurement window: 4 days before vs. 5 days post-dose

[Bryan Johnson @bryan_johnson]

good morning everyone. doing the 5.24 grams of mushrooms yesterday was one of the best days of my life. it was healing, energizing and full of love.

the coolest thing was doing this together, from the livestream crew and my team to so many of you, we had a deeply impactful shared experience. my phone has been blowing up. many tell me they called their parents, children and friends to express love and gratitude. that they have a renewed energy for health and life.

life feels so fresh.

i sincerely wish all the best for each of you. life is very hard and everyone is trying their best. we also make life so much harder on ourselves and each her than is necessary. i have hope that a new era of human existence is just around the corner and we might just be able to wrestle our most destructive instincts and amplify the splendor.

i deeply appreciate my co-founder @_katetolo, she just makes everything better and more radiant.

@RyanMField i’m very proud that we built the brain interface Kernel Flow. it was incredibly hard which makes the joy of using it to quantify my brain in this experiment a special kind of joy. Dr. Seger thanks for keeping me on task to get the biomarkers done lol

thanks to my team for working so hard. thank you @ashleevance @naval @friedberg @Benioff @gjurvetson @HamiltonMorris for being good friends and holding space as I went inwards.

@Grimezsz your set was magical. surreal. perfect. i really felt like i could see you and your artistic beauty.

@AutismCapital you’re great. i don’t know who you are but you were first on the internet to start playing with me and i deeply appreciate and enjoy your presence.

and thanks to my dad, son @talmagejohnson_ and @_katetolo for being by my side. that family time was the very best life has to offer.

all my best to all of you 💙

[Hege Røsåsen @hrosasen]

@bryan_johnson Get up and dance to your favorite music with your favorite people. Dance mostly with your eyes closed. I bet my little finger that a study on dance and psychedelics would show even better results than staying only on a mattress. But only dance 1-3 hours. Quiet is also needed.

[Hege Røsåsen @hrosasen]

@bryan_johnson Psychedelics, including psilocybin, can lead to a healthier life style. Perhaps this factor is just as important to consider regarding longevity.
https://t.co/ZtkIVjttSL