IBSResearch

Tracking research and drug development pertaining to Irritable Bowel Syndrome. The official Twitter continuation of the subreddit r/IBSResearch
#IBS;#DGBI

[IBSResearch @ibs_research]

Results of the r/IBSResearch Survey 2020 on Reddit - #IBS #Bloating #VisceralPain #Gut #Survey #Gastroenterology

[NYU Pain Research Center @NYUPainResearch]

New research from the Lewin and Coscia Labs maps the proteomes of individual sensory neuron subtypes, revealing how protein-level changes drive nociceptor sensitization, opening fresh avenues for #painresearch. https://t.co/74WpaJVd1s

[Rajan Singh @Rajan___Singh]

🚨Thrilled to share our recent #GastroDigest @AGA_Gastro 🆕🔥
From Gut Sensing to Feeding Suppression: Tuft–#Enterochromaffin Cell Crosstalk Reveals a New Frontier in Gut–Brain🧠Communication‼️
@AmerGastroAssn 🙌
With Prof. Kara Margolis @karagm2009🙏😇
📢 How does #parasite infection reduce food intake❓
🎯#Serotonin, the body’s multitasking maestro, is famed for orchestrating #motility & #mood 🧠💡
🎯 A fascinating #neuroimmune mechanism in the gut epithelium that underlies the link between parasitic infections & feeding suppression
⏩ Tuft cell–enterochromaffin cell–vagal axis that translates mucosal sensing into feeding refusal @Nature Prof. #DavidJulius et al. @UCSF👏
✅ Parasite-responsive #tuft cells engage crypt-residing EC cells in a #cholinergic relay that activates #vagal circuits and suppresses feeding in the setting of type 2 inflammation‼️
👉https://t.co/KbiBNCfeSJ
👉https://t.co/CEXaIgs87F
#Neurogastroenterology #Motility #Serotonin #GutBrainAxis

[IBSResearch @ibs_research]

High-density soft bioelectronic fibres for multimodal sensing and stimulation
"feasibility of our S-NeuroString for post-operative multimodal continuous motility mapping and tissue stimulation" #GITwitter #FutureOfGI #MedTwitter #neuropathy
https://t.co/rfL5BYc9NU

[Gastroenterology @AGA_Gastro]

Why do some celiac patients fail a #Gluten-Free diet? New research shows that in these cases, certain immune cells can grow and survive independently of gluten, sometimes becoming resistant to treatment. Read more at https://t.co/XDvq93dQZb
#CeliacAwarenessMonth

[Ali Rezaie MD MSc @AliRezaieMD]

Great to see objective changes associated with vagal nerve dysfunction on gastric electrophysiology. This opens possibilities to objectively assess treatment response. @DDWMeeting

[CMGH @AGA_CMGH]

📑 Check out this research article published in the latest issue of CMGH ➡️ "GPR68, A Proton-sensing GPCR, Mediates Acid-induced Visceral Nociception"
🔗 https://t.co/Xt4FGB6Erq
👨‍⚕️ @ LukePaine4, @psalmotoxin

[Neurogastro & Motil @NGMJournal]

🆕🔥Medically Refractory Constipation With #ColonicHypercompliance: Comparison With #Megacolon and Healthy Colon‼️
🎯Medically-refractory chronic constipation has colonic compliance similar to that of patients with megacolon👏
👉https://t.co/euu13hJWiI
@ANMSociety @esnm_eu

[IBSResearch @ibs_research]

@EdinPublishing @NGMJournal @Rajan___Singh @ANMSociety @esnm_eu @IBS_Maastricht @IFFGD @LinChangMD @mgrover_gi @BeyderLab @BMoshiree @karagm2009 @john_damianosMD @NehaSantucciMD it would if fMRIs weren't complete garbage. back to witchcraft

[IBSResearch @ibs_research]

@psalmotoxin @UnivCamPharm Nice work! PAR2 keeps delivering, thank you for all the good work your lab is doing on visceral pain.
We're following at least two inhibitors in the pipeline, more in preclinical to come. Might get a trial in the not too distant future hopefully.

[Ewan St. John Smith @psalmotoxin]

Excited to have this paper out from our @UnivCamPharm lab: "Monoclonal antibody inhibition of PAR2 reduces phenotype severity and pain in murine inflammatory bowel disease"

https://t.co/pYAgfy351d

[nature @Nature]

Nature research paper: A µ-opioid receptor superagonist analgesic with minimal adverse effects

https://t.co/qXK8DXMe7R

[Rajan Singh @Rajan___Singh]

Dive into our latest #GastroDigest in @AGA_Gastro🆕🔥
🚨From #Nociception to #GutImmunity: Neuro-epithelial TRPV1-Tuft cell circuit orchestrates #Type2Inflammation‼️ @AmerGastroAssn🙌 Anti #Helminth type 2 immunity👏
With Prof. Kara Margolis @karagm2009🙏😇
⏩A blueprint for how neuronal sensory inputs shape epithelial differentiation & orchestrate tissue- & cell-specific immunity at barrier surfaces to control Th2-related gut immunity💡
🎯Clinically, neuro-epithelial circuits offer a mechanistic bridge between neural state & barrier immunity⏩Roadmap for neuro-immunomodulatory therapeutics that tune epithelial programs rather than broadly suppressing immunity💊🔥
📢Key takeaways:
🎯Activating TRPV1+ nociceptors ⬆️CGRP, enhances #tuft cell accumulation, ⬆️#goblet cell responses, & strengthens anti-helminth type 2 protection👏
🎯#Functional coupling between TRPV1+ neurons, tuft cells, & type 2 immunity✨
⏩A detailed #map of TRPV1+ sensory convergence circuit🌟
👉https://t.co/V8New9DF7Q
👉https://t.co/q878yow3RY
@AmCollegeGastro @my_ueg @ANMSociety @esnm_eu @GutBrainScience @unrmed @NYUPainResearch @MargolisLabNYU @RomeFoundation @RomeGastroPsych @BrainSinai @IcahnMountSinai @NatRevGastroHep @NGMJournal @IFFGD @INMAssociation @anma_i @ANGMA_AU @MRC_microbiome @GMFHx @TARGID_KULEUVEN

[Waggoner Lab @LabWaggoner]

Inflammation rewires the enteric nervous system through neurogenic monocyte recruitment
https://t.co/jClZXs69e3 @JExpMed @UMassChan

[GutMicrobiota Health @GMFHx]

Could a bacterium in yogurt diagnose diseases?

@ktguzz introduces Record-seq, a tool developed in @randall_platt's lab @ETH_BSSE that enables bacteria to record what they do over time in the gut

@ISAPPscience @ISAPPSFA 

https://t.co/ITDeNqbmHu

[Neurogastro & Motil @NGMJournal]

🆕🔥A pilot validation study of🌱plant‐based & allergy‐friendly alternative for testing #GastricEmptying #HealthyParticipants‼️
🎯Tested #vegan egg meal appears to be a suitable alternative to standard egg meal for patients who are not able to eat eggs👏
👉https://t.co/nh8RIs34Ob

[Neurogastro & Motil @NGMJournal]

🆕Oral local #Budesonide treatment ameliorates immune activation & colonic sensitivity in a model for #DGBI‼️
🎯#Budesonide prevented hypersensitivity to #distention⏩Pathophysiological relevance of #eosinophils & #mast cells to symptom generation👏
👉https://t.co/ycwABsV6Mf

[Neurogastro & Motil @NGMJournal]

🚨@NGMJournal Jan 2026 issue is live🔥
✅Be sure to check out
📢https://t.co/YNIixfIYNa
@IBS_Maastricht @AndreaShin_GI @mpj61 @nicolascenac @NehaSantucciMD @KristenSEdwards #AllisonMalcolm #DavidReed @Pierfra_Visaggi @ThisIsButt #KristinElfers #WilmarieMorales @Rajan___Singh👏

[The Lancet Gastroenterology & Hepatology @LancetGastroHep]

New review - Mechanisms and pathophysiology leading to development of small intestinal microbial dysbiosis

https://t.co/dUwKXTSHg7

#GITwitter #MedTwitter

[IBSResearch @ibs_research]

This is how far the termites have spread...
prepare to be gaslit

[Rome Foundation @RomeFoundation]

We’re honored to welcome Laurie Keefer, PhD as Chief Executive Officer of the Rome Foundation. An internationally recognized leader in gut–brain care and Chair of our GastroPsych Group, her leadership reflects the future of our mission. Congratulations, Dr. Keefer!

[Mucosal Immunology @MucosalImmunol]

ILC3s mediate intestinal immune-epithelial interactions via TGF-β1 activation: https://t.co/cvOYAZMHoG