Injae Chung

Currently conscripted (alternative military service) | PhD @MRC_MBU @Cambridge_Uni

[Injae Chung @injae_chung]

Delighted to share that our latest cryo-EM work on ubiquinone-10 binding to mitochondrial respiratory complex I and conformational transitions accompanying Q-site occupancy is now out in @NatureComms!
@MRC_MBU @ArantesLab @HannahRBridges1 @BinerOlivier

https://t.co/GTLjwrK3ck

[Simon Newstead @inwardopen]

An exciting time in Solute Carrier research. Here are some of the areas where SLC structural biology is heading and where future opportunities for new discoveries and therapeutic interventions await. https://t.co/JHeCx7weEt https://t.co/UVm6apASDk @BiochemOxford @KavliOxford

[Stanislau Yatskevich @StanislauY]

Happy to see one of the last pieces of my PhD work published!

Very lucky to have awesome @TDendooven as a partner in crime

Also many thanks to @AlisterBurt, Dom, John, David and @RappsilberLab

[Matt Higgins @ParasiteMatt]

This immungen elicited a high-quality growth inhibitory response. We also showed that a first dose of this highly focused immunogen, followed by subsequent doses of the broader immunogen, PfRH5, was most effective. Read all about it here:
https://t.co/342QdtiM1s

[Stanislau Yatskevich @StanislauY]

Happy to see our work on the structure of the outer kinetochore in print
https://t.co/VvKmx2snJy

Special thanks to David, Dom, @JYang188 and @ZhangZiguo

Glad to see the complementary study by @AndreaMusacchi1,@polley_dilse and @TobiasRaisch in the same issue! Congratulations 🎉

[Hannah R Bridges @HannahRBridges1]

I'm delighted to share that the peer-reviewed version of our work investigating the molecular effects of NDUFS4 knockout on mitochondrial complex I is now published in The EMBO Journal @MRC_MBU https://t.co/xxgRPlHSDI

[Injae Chung @injae_chung]

Structural basis of a regulatory switch in mammalian complex I
https://t.co/M9DwVdmxcd

A tour de force by Dan & John!👏🏼
Using coupled vesicles, they finally clarify the enigma surrounding the cryoEM open/closed & biochemical active/deactive states of complex I
#HirstLab @MRC_MBU

[Current Opinion/Research in Structural Biology @COSB_CRSB]

Awarded COSB best paper of 2022! This review explores mechanistic interpretations of closed/open states of mammalian complex I using cryoEM.
@injae_chung @MRC_MBU
https://t.co/fdzZdfISJI

[Nils-Göran Larsson @mitopinionated]

Read our paper that is out in Cell Metabolism. We have profoundly depleted respirasomes in all tissues of the mouse. Surprisingly, bioenergetics and physiology is unaffected: https://t.co/pxViOAqBO6

[Hannah R Bridges @HannahRBridges1]

A number of historical cryoem datasets of complex I for published structures from the Hirst lab have now been released on EMPIAR: EMPIAR-11648, EMPIAR-11653, EMPIAR-11654, EMPIAR-11655, EMPIAR-11656, EMPIAR-11657, EMPIAR-11672. Happy processing all!

[Anna Howes @HowesAnna]

Delighted to share my first first-author paper in @ScienceAdvances 🥳We determined the structure of H2O2-activated ATM bound to p53 peptide substrate and suggest a mechanism for ATM activation by oxidative stress.🧵(1/11)
https://t.co/5sxL7nP1O4

[Nils-Göran Larsson @mitopinionated]

Very happy to see our paper published. Thanks to all coauthors for a very nice collaboration!

[Karolinska Institutet @karolinskainst]

A new study published in @Cell_Metabolism by @mitopinionated at KI shows that supercomplexes have no major role in cellular energy production and that altered levels therefore are unlikely to affect physiology and disease. #mitochondria #metabolism
https://t.co/qjpPpbV7PU

[Stanislau Yatskevich @StanislauY]

Happy to share our work on the structure of the human outer kinetochore KMN network complex

Many thanks to David Barford, Dom Bellini, @JYang188 and @ZhangZiguo for working with me on this project.

https://t.co/BQuK5cmwKc

[Injae Chung @injae_chung]

Very happy to share our most recent work in @ScienceAdvances where we analyse the networks of charged and polar residues and water molecules present in a 2.4-Å resolution structure of murine respiratory complex I to gain insights to candidate proton pathways and hydrated channels

[Hannah R Bridges @HannahRBridges1]

Investigation of hydrated channels and proton pathways in a high-resolution cryo-EM structure of mammalian complex I | Science Advances https://t.co/Osh1OZdlpU @injae_chung @MRC_MBU

[Simon Newstead @inwardopen]

And here is the finalised paper https://t.co/AFKVmYFPVV
again, super work from @oxkawaka , Dr Jo Parker & Dr Gabriel Kuteyi - go team!

[Hannah R Bridges @HannahRBridges1]

I'm very happy to be able to share our preprint on structurally characterising the effects of NDUFS4 knockout on mouse complex I https://t.co/v489dPpbJv

[Nils-Göran Larsson @mitopinionated]

Our preprint show that knock-in mice with drastically reduced levels respirasomes have normal OXPHOS function and no obvious phenotypes! Very unexpected results indeed! Presented the story at EuroMit. Thanks all coauthors for a very nice collaboration!
https://t.co/xDlQrB0HVp

[Guilherme M. Arantes @ArantesLab]

Happy to share our work on rotenone binding to respiratory complex I !

Rotenone is an archetypal natural product discovered centuries ago by the indigenous peoples of the Amazon, where it is still used today to aid in catching fish. (1/2)

https://t.co/cw6VmdPHD1

[bioRxiv @biorxivpreprint]

The antipsychotic medications aripiprazole, brexpiprazole and cariprazine are off-target respiratory chain complex I inhibitors https://t.co/ZBDNFdO5kz #bioRxiv

[Hannah R Bridges @HannahRBridges1]

Structural basis of mammalian respiratory complex I inhibition by medicinal biguanides https://t.co/VDqiU5Bizj

I think you all deserve a new 🧵