M.D./Ph.D student. Studying regulation of one carbon metabolism in aging biology. Clinical interests in anesthesiology and critical care. @EinsteinMed.
1/ New preprint from the lab, led by MSTP student @isaackraz: https://t.co/cfgICKt3cy
SAM (S-adenosylmethionine) is the universal methyl donor used for DNA, RNA, protein, and metabolite methylation. Maintaining SAM homeostasis is essential - but how is it regulated?
Why can’t cells live without PRMT5? Our new transformative work inspired and led by @JacobRoth13 shows that this arginine methyltransferase is critical for histone production and genome stability.
Full story: https://t.co/KzdnInZcEV
1/5
Just out in Biochemistry ASAP🧪. We characterized detailed hsART1 kinetics and described the order of substrate binding and product release. https://t.co/TgWfpUGs5z
Have you ever wondered how PRMT5 actually influences gene expression? See our new work - “Productive mRNA Chromatin Escape is Promoted by PRMT5 Methylation of SNRPB”. Preprint here: https://t.co/0OwzNc4hn8 1/5 #MolecularBiology
@Sorrell_Lab@Zhu_Lab @RJDLab @ASolmonson Awesome work! I'm curious if you've speculated as to why serum methionine levels increase so dramatically in the Trp-starved condition?
Breaking News: Dr. Ruth Gottesman, a former professor, has donated $1 billion to a Bronx medical school, the Albert Einstein College of Medicine, with instructions that the gift be used to cover tuition for all students going forward. https://t.co/ReBHEamR50
@LauraMaule3 the one thing that helped me the most while studying for Step 1 was realizing that UWorld is a study resource first and an assessment tool second. Trust the process, be persistent, and you'll be on the other side before you know it.
Ever wonder why histone chaperones have acidic tails?
Our new preprint reveals they mimic DNA to regulate chromatin! Glutamate-glutamylation enhances their mimicry.
Dive in: https://t.co/n1MIumdmGe lead by @B_Lorton23 Chris Warren @HumairaIlyas8#biorxiv 1/7
From Disorder to Dynamo: Glutamylation's Role in Supercharging Histone Chaperones
I am thrilled to share our latest and groundbreaking work on histone chaperone glutamylation. Find our preprint here https://t.co/gvpjs1lgHi
Thank you @DShechter and others for your contributions!
@avikohanzadeh @OpenAI https://t.co/LK8v2zH4j2 old article but this is one great example of how machine learning algorithms can be applied to improve patient outcomes.
Many thanks to the @EinsteinMed@EinsteinPhD leadership for hearing trainee concerns surrounding increased cost of living and working diligently to secure increases to grad student and postdoc stipends
I’m searching for professional connections and mentorship from docs who have completed/are currently in a combined critical care + nephrology fellowship. TIA! #MedTwitter#CriticalCare#nephrology