Isaac Krasnopolsky, M.S.

M.D./Ph.D student. Studying regulation of one carbon metabolism in aging biology. Clinical interests in anesthesiology and critical care. @EinsteinMed.

[Isaac Krasnopolsky, M.S. @isaackraz]

Is there an avocado shortage? My millennial senses are tingling.

[David Shechter @DShechter]

1/ New preprint from the lab, led by MSTP student @isaackraz: https://t.co/cfgICKt3cy
SAM (S-adenosylmethionine) is the universal methyl donor used for DNA, RNA, protein, and metabolite methylation. Maintaining SAM homeostasis is essential - but how is it regulated?

[David Shechter @DShechter]

Why can’t cells live without PRMT5? Our new transformative work inspired and led by @JacobRoth13 shows that this arginine methyltransferase is critical for histone production and genome stability.

Full story: https://t.co/KzdnInZcEV
1/5

[Isaac Krasnopolsky, M.S. @isaackraz]

Congrats to Daniel @Dan__Groom on this impressive publication! #enzymes #kinetics #NAD #ADPribosylation #PARP👇

[Dan @Dan__Groom]

Just out in Biochemistry ASAP🧪. We characterized detailed hsART1 kinetics and described the order of substrate binding and product release. https://t.co/TgWfpUGs5z

[David Shechter @DShechter]

Have you ever wondered how PRMT5 actually influences gene expression? See our new work - “Productive mRNA Chromatin Escape is Promoted by PRMT5 Methylation of SNRPB”. Preprint here: https://t.co/0OwzNc4hn8 1/5  #MolecularBiology

[Isaac Krasnopolsky, M.S. @isaackraz]

@Sorrell_Lab @Zhu_Lab @RJDLab @ASolmonson Awesome work! I'm curious if you've speculated as to why serum methionine levels increase so dramatically in the Trp-starved condition?

[Isaac Krasnopolsky, M.S. @isaackraz]

@hamhatch Congratulations, Hayden!

[The New York Times @nytimes]

Breaking News: Dr. Ruth Gottesman, a former professor, has donated $1 billion to a Bronx medical school, the Albert Einstein College of Medicine, with instructions that the gift be used to cover tuition for all students going forward. https://t.co/ReBHEamR50

[Isaac Krasnopolsky, M.S. @isaackraz]

@LauraMaule3 the one thing that helped me the most while studying for Step 1 was realizing that UWorld is a study resource first and an assessment tool second. Trust the process, be persistent, and you'll be on the other side before you know it.

[Isaac Krasnopolsky, M.S. @isaackraz]

Wishing all my @EinsteinMed class of 2024 MD peers best of luck as they submit their residency applications this week!

[David Shechter @DShechter]

Ever wonder why histone chaperones have acidic tails?

Our new preprint reveals they mimic DNA to regulate chromatin! Glutamate-glutamylation enhances their mimicry.

Dive in: https://t.co/n1MIumdmGe lead by @B_Lorton23 Chris Warren @HumairaIlyas8 #biorxiv 1/7

[Benjamin Lorton @B_Lorton23]

From Disorder to Dynamo: Glutamylation's Role in Supercharging Histone Chaperones

I am thrilled to share our latest and groundbreaking work on histone chaperone glutamylation. Find our preprint here https://t.co/gvpjs1lgHi

Thank you @DShechter and others for your contributions!

[Eric Topol @EricTopol]

It seems like sci-fi. They engineered bacteria to detect colon cancer.
https://t.co/UcZGWBwkPX @ScienceMagazine #synbio

[Isaac Krasnopolsky, M.S. @isaackraz]

@RajuBrainLab @HellerLab Congratulations!!

[Isaac Krasnopolsky, M.S. @isaackraz]

@lydfinley @MSKCancerCenter Will a Zoom link be available? I'd be really interested in tuning in.

[Isaac Krasnopolsky, M.S. @isaackraz]

@KentsisResearch Truly rules to live by. Congratulations Alex!

[Isaac Krasnopolsky, M.S. @isaackraz]

@avikohanzadeh @OpenAI https://t.co/LK8v2zH4j2 old article but this is one great example of how machine learning algorithms can be applied to improve patient outcomes.

[Isaac Krasnopolsky, M.S. @isaackraz]

@DrSarahAxelrath My assay wouldn’t work

[Isaac Krasnopolsky, M.S. @isaackraz]

Formally declared today in the @DShechter lab at @Einsteinmed - feat. Dr. @MaximMaron 's enthusiastic thumbs up :) Photo Creds: @HumairaIlyas8

[Carl Pierce, MD, PhD @carlpierce]

Many thanks to the @EinsteinMed @EinsteinPhD leadership for hearing trainee concerns surrounding increased cost of living and working diligently to secure increases to grad student and postdoc stipends

[Isaac Krasnopolsky, M.S. @isaackraz]

I’m searching for professional connections and mentorship from docs who have completed/are currently in a combined critical care + nephrology fellowship. TIA! #MedTwitter #CriticalCare #nephrology