Our new preprint is out! "Systemic Tissue and Cellular Disruption from SARS-CoV-2 Infection revealed in COVID-19 Autopsies and Spatial Omics Tissue Maps" https://t.co/KcPkiJQuX9 with @ElementoLab@skimomiks @nanostringtech @illumina and many great scientists from @nygenome
Our new paper with @OdedRechavi came out today in @CellCellPress! "Illuminating Genetic Mysteries of the Dead Sea Scrolls" https://t.co/hu7DqFgMlK. 7 years in the making with tireless work from Oded to get it right; sets a precedent for genetically-driven artifact reconstruction.
Our new @biorxivpreprint is up! "Host, Viral, and Environmental Transcriptome Profiles of SARS-CoV-2." COVID-19 patients (n=338) examined w/ qRT-PCR, RT-LAMP, & total RNA-seq, host responses (e.g. ACE2) & new diagnostic methods. https://t.co/lsPfzh8cOq Some highlights: /1
This is especially interesting after just a few years ago discovering (in a different species) eight large, circular, largely non-coding mitochondrial chromosomes: https://t.co/AHb7Ezh0KG maybe just the tip of the iceberg for myxozoan mitochondrial evolution?
Amazing new work from the Huchon lab showing evolutionary loss of mitochondria in a myxozoan species -- in other words, an animal that doesn't need oxygen to survive. Featured in the NYT! https://t.co/TdgbXj3ZKl
“We find that long telomeric stretches can be accurately captured with long-read sequencing.” Learn how @LankyCyril@jfoox@mason_lab & co were able to discover novel & known non-canonical motifs w/ new edgeCase framework & @GenomeInABottle seq data. https://t.co/cep5XKPzW9
Nanopolish v0.12 supports live methylation calling, while the sequencer is running. An update worthy of dusting off the old blog for: https://t.co/8ETJlj5OUX.
@mitenjain showing the fast Shasta pipeline for fast human genome assembly, with N50 results in the 20-30Mb, a low error rate (~1%), and reasonable cost ($70) for an @awscloud assembly and MarginPolish and Helen polishing to remove homopolymers #ABRF2020
A 2.44 Mb human read- the longest sequenced DNA molecule to date! @circulomics Kevin Liu shows updates to the @mattloose, @pathogenomenick, and @Scalene long-read protocol, w/ more >1Mb reads (whales) & even “pods of whales” on @nanopore, also helped by a nuclease flush #ABRF2020
@jfoox rocking an Epigenomics talk and covering all the @nanopore methods and applications. He noted that the hotel art at #ABRF2020 looks at lot like squiggle plots of Pico-amp current data ;-)
Sharing slides from my #ABRF2020 talk on detecting base modifications in @nanopore data – with a special shout out to all the fish-based software names! Thanks to @mitenjain@stoibs11 and the many awesome members of the ONT informatics community https://t.co/0kRN2y9a9H