⤵︎

Generalist

[⤵︎ @johnha]

@RaminNasibov @elonmusk Moria. and Descent

[Neetu Arnold @neetu_arnold]

University of California STEM professors want standardized tests back due to severe math deficiencies among students:

“We now observe preparation gaps so severe that instructors must reteach middle school mathematics”

“The current admissions metric, based primarily on GPA & essays, can no longer reliably distinguish readiness for university-level STEM majors in an era of severe grade inflation & AI assisted application essays”

[Seth Howes @SethSHowes]

I just sequenced a human genome to 30× coverage entirely at home.

As far as I know, this is the first time this has been done.

I didn’t step foot in a lab once. Every step - from saliva collection, to running the sequencer - took place in a single room with a dining table + kitchenette.

Six weeks ago, I had never done wet lab biology before.

I used an Oxford Nanopore P2 Solo - the only commercially available sequencing device portable enough to do 30x human genome sequencing at home.

Biggest takeaway - I could build something that combined software, hardware, and molecular biology far faster than I thought was possible.

I can name >100 specific instances where AI helped me solve a technical problem that would previously have blocked me because I lacked access to a domain expert.

For example: how do I save my sequencing run when my DNA extraction yield is 4x lower than I need it to be, and I have this limited set of reagents to hand?

To make this work, I had to navigate multiple disciplines:

- writing software to monitor sequencing runs and orchestrate remote GPU infra for basecalling
- learning + executing 5 hour long molecular biology protocols
- building a hardware device to quantify DNA concentration

Apologies for the hyperbole, but I feel super lucky to be living in 2026.

A few weeks ago I decided to sequence a human genome to 30x at home.

Then I actually did it. And I did it really quickly.

[Zet Lorento @ZetLorento]

ExpressVPN, @torproject, Tuta, Mozilla, @EFF and Mullvad, alongside 13 other organizations advocating for digital privacy rights, have published an open letter.

In the letter, they express serious concerns regarding the age verification measures planned for implementation across the internet following the introduction of a new child protection law.

The organizations argue that forcing users to prove their age across most websites and online services could severely undermine privacy, anonymity, and the open nature of the internet.

The central message of the letter is that protecting children should not come at the cost of jeopardizing the freedom, security, and privacy of all internet users. The signatories are calling for more balanced, privacy preserving solutions to be developed instead.

The 19 organizations that signed the letter are:

1- Big Brother Watch
2- Defend Digital Me
3- Electronic Frontier Foundation
4- ExpressVPN
5- Gamers Voice
6- Global Partners Digital
7- Index on Censorship
8- Internet Society
9- Mozilla
10- Mullvad
11- IPVanish
12- NO2ID
13- Open Rights Group
14- Privacymatters
15- Proton
16- Stop Killing Games
17- Tor Project
18- Tuta
19- VPN Trust Initiative

[Allie ✞ @allie__voss]

Whenever there’s a question of “Why is ____ so expensive???”

The answer is almost always a collection of regulations you had no idea exist

[Alec Stapp @AlecStapp]

One of my favorite stats that serves as a reality check for people:

The median American took zero flights last year.

[Paul Graham @paulg]

It's so weird how difficult it is for the left to understand that all you have to do to decrease housing costs is to let people build more housing.

[⤵︎ @johnha]

@paulg Saw this and thought of you https://t.co/QhL3sI2YdJ

[⤵︎ @johnha]

@TheCinesthetic Kingpin
Old School
Bridesmaids
Wedding Crashers
Hangover
As Good As it Gets
American Pie
50 First Dates

[⤵︎ @johnha]

@Jason I'm in

[⤵︎ @johnha]

@theo I synchronize Claude Code cli between my phones Macs and Linux boxes so I can start and resume sessions anywhere. Works great

[Chris Anderson @chr1sa]

I love this story.

First, Boom's jet engine supplier, Rolls Royce, pulls out of the supersonic airliner deal. That should have been the end of the story. As GE often says, "if you want to compete with us in jet turbines, you needed to have started 30 years ago", because that's how long it takes. So it would be crazy to start now.

But Boom didn't fold up tents. They said they were going to make their own jet turbine. Good luck 🙄

But they started anyway, and then "a miracle occurs": the AI datacenter boom creates unbounded demand for gas turbines, creating at least a 4-5 year backlog with existing manufacturers.

And because the Boom terrestrial turbine power plants don't have to be certified by the FAA, that takes a decade off their path to market!

So now 90% of the company is working on the turbines, with a huge pipeline of orders, and they're going to be a huge energy company, regardless of whether they ever ship an airplane or not.

What a great testament to resilience. Just keep moving forward and eventually the path will become clear. Action creates information.

[⤵︎ @johnha]

@chamath @karpathy *addressed (autocorrect error ugh)

[⤵︎ @johnha]

@chamath @karpathy toddard this recently: https://t.co/8weAi1g6Y0

[Andrej Karpathy @karpathy]

Wow, this tweet went very viral!

I wanted share a possibly slightly improved version of the tweet in an "idea file". The idea of the idea file is that in this era of LLM agents, there is less of a point/need of sharing the specific code/app, you just share the idea, then the other person's agent customizes & builds it for your specific needs.

So here's the idea in a gist format: https://t.co/NlAfEJjtJV

You can give this to your agent and it can build you your own LLM wiki and guide you on how to use it etc. It's intentionally kept a little bit abstract/vague because there are so many directions to take this in. And ofc, people can adjust the idea or contribute their own in the Discussion which is cool.

[⤵︎ @johnha]

@MurrayHillGuy1 https://t.co/z1lx7qW9ll

[⤵︎ @johnha]

@vxunderground Are you a tall guy??

[⤵︎ @johnha]

@MurrayHillGuy1 Why don't women need to enter their weight or even self disclose "body type" this used to be a thing on https://t.co/2RRXZkS1fp thin athletic average a few extra pounds

[⤵︎ @johnha]

@paulg Please save all of us @nikitabier! Most posts are like this now making it unbearable to use X. I guess it's difficult to detect bot written posts, otherwise this would already be fixed.. force bots to disclose they are bots. Allow human users to filter out bot posts in settings

[⤵︎ @johnha]

@Handre Is there any solution, or do we just gripe and bear it

[⤵︎ @johnha]

@NumberCrun77 @datingbyblaine I think this is the primary belief. Can you refute with any real data?