Jason Osajima 🦾

[Jason Osajima 🦾 @josajima]

@luagaroz video

[Jason Osajima 🦾 @josajima]

@simonlast Claude really latched on to the coal shoveling metaphor

[Jason Osajima 🦾 @josajima]

@adriansolarzz slides

[Jason Osajima 🦾 @josajima]

@Manu_Sisti Doc

[Jason Osajima 🦾 @josajima]

@MichLieben Claude Code

[Jason Osajima 🦾 @josajima]

ClockBase Agent scanned 43,602 intervention comparisons and found 500+ that significantly reduce biological age. the top hits, rapamycin, metformin, quercetin, nicotinamide riboside, overlap almost perfectly with what the longevity community spent decades converging on. but it also flagged ouabain and fenofibrate, which nobody was really talking about. they tested ouabain on old mice and it prevented age related frailty

[Jason Osajima 🦾 @josajima]

@danshipper @reidhoffman the hard part with this advice is that new model capabilities drop every few weeks and invalidate the workflow you just set up. it's hard to build habits on infrastructure that keeps shifting

[Jason Osajima 🦾 @josajima]

@alliekmiller same thing when I'm about to go to sleep

[Jason Osajima 🦾 @josajima]

@AlexHormozi every yes to the main thing is a no to something that also mattered

[Jason Osajima 🦾 @josajima]

@paulg reading is becoming a form of alpha. if 75% of people don't read, the information asymmetry for the 25% who do is actually growing

[Jason Osajima 🦾 @josajima]

@AlexHormozi AI makes this more true not less. the floor rose but the ceiling didn't move

[Jason Osajima 🦾 @josajima]

@PeterAttiaMD @foundmyfitness creatine section was the standout. at higher doses it's a brain supplement that also happens to help muscles

[Jason Osajima 🦾 @josajima]

@foundmyfitness brb upgrading my measuring spoon. $0.03/gram and it might be the most underpriced cognitive supplement on the market

[Jason Osajima 🦾 @josajima]

@davidasinclair took 40 years from "smoking causes cancer" to actual regulation

[Jason Osajima 🦾 @josajima]

@foundmyfitness BEYOND well-rested baseline?? that's not "creatine helps when you're tired," that's "creatine is a cognitive enhancer, period"

[Jason Osajima 🦾 @josajima]

@bryan_johnson the protocol is the content, the measurement system is the moat. making longevity trackable is what separates this from wellness vibes

[Jason Osajima 🦾 @josajima]

@lennysan @every @danshipper it's the same reason the best restaurant owners still cook. you can't delegate judgment about a tool you've never used

[Jason Osajima 🦾 @josajima]

@EricTopol @NEJM_AI @pranavrajpurkar specialist models win benchmarks but generalist models win deployment. hospitals can't run 47 different models for 47 different imaging tasks

[Jason Osajima 🦾 @josajima]

@levelsio every workflow and work itself might end up wrapped in a world model built by AI. we're not far from work becoming something you navigate in 3D rather than click through in 2D

[Jason Osajima 🦾 @josajima]

@danshipper the trench coat is the hard part though. sitting with teams, understanding their actual workflows, deploying forward engineers to figure out what to build. the agent is interchangeable, the context isn't