Juanfe Ramirez-Contreras

MD and former PhD student (UdeC, CL): current GP at UBB, Ñuble, CL. MSc CogSci (CCiL at UB, ES). Posts ESP(chilean)/ENG. Interested in neuroprogression

[Juanfe Ramirez-Contreras @juanferamirez]

reductio ad cell

[Wallace Marshall @WallaceUcsf]

Cognition as a cellular phenomenon

[Elisabetta Lalumera @elila74]

My new chapter “Conceptual Engineering of Medical Concepts,” just out in New Perspectives on Conceptual Engineering vol 3 (Springer).
I show how medicine constantly engineers its own concepts—like cancer and obesity—for epistemic, ethical, and policy goals
https://t.co/gY2HJueWb8

[Juanfe Ramirez-Contreras @juanferamirez]

@medel2025 @vera_carrera por aquí también un interesado, que no podrá asistir a su charla hoy, profesor 🙏 muchas gracias de antemano

[Pablo Munoz @pablo_jack]

QEPD la gran Doctora Katia Gysling, excelente docente, cercana profesora en la facultad, y una gran neurocientifica. Un honor haber tenido clases con ella.

[Nicholas Fabiano, MD @NTFabiano]

Schizophrenia may be on the autism spectrum.

🧵1/10

[vittorio @IterIntellectus]

holy shit

MIT researchers just turned skin cells directly into neurons without stem cell intermediate, 100-fold efficiency boost, and they actually worked when transplanted into mouse brains

1/

[Juanfe Ramirez-Contreras @juanferamirez]

@dylansmith2828 @rostotona @adalozzo Aclaración: excepcionalmente un café tiene 200 mg de cafeína. Lo habitual es 80-150 mg que es bastante menos en la falsa proporción que intentas establecer (las energéticas tienen solo 2x de cafeína que 1 taza de café). Un principio de la medicina es la relación dosis-respuesta.

[CLaE @leafs_s]

Neuron

Nucleus Accumbens Subnuclei Regulate Motivated Behavior via Direct Inhibition and Disinhibition of VTA Dopamine Subpopulations

https://t.co/oO6C5OKaSY

[Eric Topol @EricTopol]

How wearable sensors (@Oura, @fitbit, or @Apple watch) detected subclinical inflammation up to 7 weeks before a flare of inflammatory bowel disease
https://t.co/JyPjWeO80g @RobertHirten @HPI_MS @MountSinaiNYC

[parm🔬 @parmita]

In a surprising paper published in Nature, scientists accomplished what sounds impossible: using genes from a single-celled organism to create mouse stem cells, which eventually developed into a living, breathing mouse.

[Prof. Nikolai Slavov @slavov_n]

Timescales in Cell Biology

[Alberto J Espay @AlbertoEspay]

An analysis of FDA’s Adverse Event Reporting (FAERS) data, just posted on @researchsquare, provides early evidence of real-world increased mortality among #Alzheimers patients treated with anti-Aβ monoclonal antibodies, aducanumab & lecanemab. 🧵 (1/6)
https://t.co/1R9tl1hSAy

[Rosario in Paris ᥫ᭡ @chayito09]

El Premio Nobel en Fisiología y/o Medicina de este año se enfoca en el descubrimiento de un mecanismo regulador vital utilizado en las células para controlar la actividad genética.
La información genética pasa del ADN al ARN mensajero (ARNm), a través de un proceso llamado
1/
©️The Nobel Prize in Physiology or Medicine 2024.

[Samuel Hume @DrSamuelBHume]

Biggest medical discoveries of the week (🧵)

1/10

A complete map of the fruit fly brain - the biggest and most detailed to date

140,000 neurons, which connect through 55 million synapses to permit vision, movement, and memory formation

(https://t.co/YTaJBwEhn2)

[🍒 Serge Ahmed 🍒 @sergeahmed.bsky.social @SergeAhmed]

The evolution of agency

The most important cause of decision-making uncertainties for agentive organisms is other agentive organisms.

[The MIT Press @mitpress.bsky.social @mitpress]

Comprehensive and deeply insightful, "A History of Bodies, Brains, and Minds" provides a brief history of life, the brain, and cognition, from the earliest living beings to our own species. #SfN24 #OpenAccess https://t.co/b55ZUISVpv

[Prof. Nikolai Slavov @slavov_n]

The distribution of ~ 2 trillion immune cells in the human body.

[Eric Topol @EricTopol]

The anti-aging impact of metformin (randomly assigned, with controls) in male monkeys after 40 months of treatment, a pan-omic clock assessment
—~6 year regression of brain aging, with prevention of atrophy and enhanced cognitive ability
—minimal effect on blood sugar
—evidence for multi-organ decelerated aging
https://t.co/ENFZHZOxZS @CellCellPress

[State_of_Mind @StateofMind_02]

@Locati0ns Satellite view of South America at night from NASA, showing the contrast between heavily populated coastal areas and the more remote regions of the Amazonian interior and Patagonia

[Epic Maps 🗺️ @theepicmap]

19. 🇨🇱 Chile's length: 4,270 km
🌑 Moon's diameter: 3,474 km

[Kei M Igarashi / 五十嵐 啓 @kei_m_igarashi]

Where in the brain is abstract map generated?
It is the lateral entorhinal cortex (LEC) and the medial prefrontal cortex (mPFC), working together!!

Here is our new finding published in @Nature

Prefrontal and lateral entorhinal neurons
co-dependently learn item–outcome rules
Heechul Jun†, Jason Y. Lee†, Nicholas R. Bleza, Ayana Ichii, Jordan D. Donohue & Kei M. Igarashi*
Nature (2024)
https://t.co/nm2Ev96ej6

When you learn new items, your learned knowledge is sorted into an “internal map” of the brain. An internal map, also called as an “abstract map”, is made of population activity of many neurons.

In this new work led by Heechul Jun @jun_heechul and Jason Lee @jasonyensunlee, we found that the LEC deep layers and mPFC co-dependently generate abstract map during learning.
These two areas had bidiretional anatomical connections, making a loop circuit. Inhibition of the LEC disrupted the abstract map in the mPFC, and mPFC inhibition deleted LEC abstract map.

Our message is: LEC and mPFC are best friends!

@AnatomyNeurobio @UCIMedSchool
@uci_bme @UCIEngineering
@UCI_NeurCircuit @ucicnlm @ucimind
@UCIrvineNews @UCIrvine