Alex Khromykh

University of Queensland

[Allen Cheng @peripatetical]

Hydroxychloroquine did not have any effect on viral clearance in a RCT. High proportion with adverse events in HCQ arm but most mild. https://t.co/fn66SgBqg3

[Alex Khromykh @KhromykhAlex]

@Enezator Прикольно

[Alex Khromykh @KhromykhAlex]

It’s great to see that our paper on reverse genetics system for SARS-Cov-2 and other positive strand RNA viruses has been selected as Editor’s Highlights in “Microbiology and infectious diseases” web page of Nature Communications https://t.co/j0Z1VPyg9y.

[Michael Makris @ProfMakris]

Amazing case report. The medicine of tomorrow. 5 week old boy admitted to NICU. Within 37 hours he had his whole genome sequenced, gene defect identified, treatment ordered and received by patient. Within 6 hr symptoms resolved. https://t.co/UYSJSURQHW

[Alex Khromykh @KhromykhAlex]

@yxsetoh Great historical summary, Setoh - thanks. Just leaves me to add that the experiments for the original WNV CPER development and for the latest SARS-CoV-2 CPER (in PC3) I actualy did myself with some help from the team, incl. you. Doing experiments still feels me with joy!

[Alex Khromykh @KhromykhAlex]

@JodyPeters20 @Alberto91592929 @yxsetoh Couldn’ agree more, Jody and sorry for mistyping James' last name - it should be James Potter of course. Our paper establishes CPER for for different polyA tail-containing RNA viruses, SARS-CoV-2 (~30kb), Casuarina virus (~20kb), Ross River virus (~12kb) and Norovirus (~7.5kb).

[Alex Khromykh @KhromykhAlex]

@DWatterson_ @NatureComms @AndreasSuhrbier @JodyPeters20 @JasonMack1234 @Alberto91592929 Indeed, Alberto was instrumental for this work with long hours in PC3 - huge thanks to him and also to all other joint first authors - Julian De Jun Sng, Rhys Parry, Josh Deerain, James Hardy and Yin Xiang Setoh. They all made vital contributions. Also thanks to QIMRB team.

[Alex Khromykh @KhromykhAlex]

Our paper on CPER-based reverse genetics system for SARS-COV-2 and other positive strand RNA is finally out in Nature Communications https://t.co/bkuKx5pwL6 big thanks to our collaborators at UQ, Uni Melb, Monash, and Queensland Health.

[Bloom Lab @jbloom_lab]

Our complete mapping of mutations to #SARSCoV2 RBD that reduce binding by convalescent human plasma is out in @cellhostmicrobe (https://t.co/F2sz3HL9tE). Right now E484K getting lot of attention, but I want to emphasize what our results suggest to keep eyes on in *future* (1/n)

[Eric Topol @EricTopol]

More details now available for South African trial w/ Astra Zeneca vaccine, regarding B.1.351 variant. Table updated, data here:
https://t.co/NekZxSDiL7 by @gksteinhauser

[Florian Krammer @florian_krammer]

This is now the third paper to find a very very good immune response after one shot of mRNA vaccine in people who had a previous SARS-CoV-2 infection. Time to discuss policy changes, @DrNancyM_CDC @CDCDirector! https://t.co/jIwBCDqNd2

[CEPI @CEPIvaccines]

The emergence of SARS-CoV-2 variants serve as a powerful reminder that viruses by their very nature mutate, and that science may need to adapt if they are to remain effective against them🔬

Statement from CEPI and our COVAX partners @gavi @WHO⏬
https://t.co/VkkEPbRlQL

[Trent Munro @trent_munro]

Great interview with Russell Basser from @CSL walking through the update on our @UQ_News #COVID19 #vaccine. While not the outcome we wanted, big shoutout to the Australian media for the accurate and balanced coverage, it means a lot to whole team who worked so hard this year! 🙏

[Alex Khromykh @KhromykhAlex]

It has been a real inspiration to see how much can be achieved with a great team of likeminded and highly motivated researchers. You guys gave it your best shot and I am sure you will rebounce back stronger than before.

[UQ News @UQ_News]

Thank you to our absolutely incredible team of scientists for their work on the #UQ/@CSLBehring COVID-19 vaccine, as well as our generous supporters and donors. While the vaccine will not be progressing, we're extremely proud of their hard work. Read more: https://t.co/GASLW4Z7go

[Alex Khromykh @KhromykhAlex]

this makes sense, athough vaccinated people can do it themselves with other available antibody tests if they really want to know whether they are vaccinated with vaccine or with placebo

[Reuters Health @Reuters_Health]

Roche is partnering with Moderna to include a COVID-19 antibody test in the mRNA specialist's ongoing vaccine trials, the Swiss drugmaker said on Wednesday, potentially demonstrating if the vaccine is working.​ https://t.co/nhwmxcPnJC

[Alex Khromykh @KhromykhAlex]

We established work with SARS-CoV-2 virus and developed a simple and rapid way to manipulate viral genome. With #nhmrc funding we could apply this to figure out how the virus causes disease and develop new antiviral drugs #advanceaustraliacare #auspol #SaveOzScience @GregHuntMP

[Alex Khromykh @KhromykhAlex]

We’ve had many years of successive @nhmrc funding for our research on medically important viruses which led to multiple reserch discoveries and development of vaccine candidates. Continuing @nhmrc funding is absolutely vital!
#advanceaustraliacare #auspol #SaveOzScience

[Ian Boys @_iboys]

1/ I am thrilled to share my first first author paper with #sciencetwitter! In our paper @cellhostmicrobe, we characterize mammalian RTP4 as a species-specific inhibitor of #flaviviruses. Some highlights: https://t.co/yPD8DdX2gD

[Alex Khromykh @KhromykhAlex]

@RhysHParry That’s interesting, Rhys. Tell me more about it tomorrow.