ZEBRALille

Zebrafish Lab in Lille - Studying cancer using gene editing, transgenesis and cell transplantation in #zebrafish @Canther_Lille @univ_lille @CNRS_HdF @CHU_Lille

[ZEBRALille @LilleZebra]

Our work on 🦓🐟 at @Canther_Lille is funded by @univ_lille @CNRS_HdF @Inserm @CHU_Lille @canceropole_no @laliguecancer du Pas-de-Calais 🙂

[ZEBRALille @LilleZebra]

🦓🐟 Keen to share our new work on the inactivation of Eed in #zebrafish @Canther_Lille #Epigenetics 👉https://t.co/a45ix0BUrx #mdpicells via @MDPIOpenAccess

[ZEBRALille @LilleZebra]

@iman_560 You are wrong. Nothing starts with N and ends with G. 😜

[ZEBRALille @LilleZebra]

@Matt_Pinner LOL. Nothing starts with N and ends with G. 🤪🤪🤪🤪

[ZEBRALille @LilleZebra]

@KarinaYaniv My thoughts are with you. Take care

[Crump Lab @CrumpLab]

The outer ear is a mammalian innovation but where did it come from? In our study in @Nature, @MathiThiru95 and colleagues find that the outer ear arose from modification of an ancestral gill program first originating in marine invertebrates. https://t.co/i05me2SXI4

1/n

[Bruno Lopes Bastos @BLopesBastos]

Excited to share our latest study! Cyclic ruthenium-peptide prodrugs penetrate the blood-brain barrier and target #glioblastoma, activated by light in orthotopic #zebrafish tumor model. A promising step toward innovative therapies! #CancerResearch

https://t.co/qvPR7Rdqkl

[Bruno Lopes Bastos @BLopesBastos]

The main study from my postdoc @MGodinhoFerr is out! #Telomerase isn't required for tumor initiation but its lack drives #Cancer #regression later. Regression occurs via tumor-autonomous mechanisms (cell cycle arrest, apoptosis, melanocyte differentiation) and immune rejection.

[Konstantinos Ampatzis @AmpatzisLab]

Excited to share @AmpatzisLab and @KizilLab's's new paper on #zebrafish 's intracardiac nervous system (IcNS), highlighting the presence of pacemaker-like neurons that partake in heart rhythm—linking cardiac and neuroscience research. https://t.co/n2OhC1kxrT

[Elena Vasileva @EVasilevaSci]

1/4 Our @biorxivpreprint, 'Origin of Ewing Sarcoma by Embryonic Reprogramming of Neural Crest to Mesoderm' is now available on bioRxiv! In this study, we explore the enigmatic origin of Ewing sarcoma using our zebrafish genetic cancer models. We revealed that neural crest cells can uniquely tolerate EWSR1::FLI1 expression, leading to tumor formation in vivo. A big thanks to our collaborators @clairearataphd and @CrumpLab for this adventurous journey! #NeuralCrest #cancer #EwingSarcoma #zebrafish @amatrudalab @ChildrensLA @biorxiv_cancer👉https://t.co/h0QP0FgX5n

[eLife - the journal @eLife]

Zebrafish study reveals clues to how inflammation drives scoliosis. https://t.co/DdGvurchEq

[Development @Dev_journal]

David Ish-Horowicz FRS (1948-2024): outstanding scientific discovery, with a unique touch of selfless humanity

An Obituary by Ilan Davis (@ilandavis), with his personal reflections on David's unique approach to science and scientific friendship:
https://t.co/y9nS4mZFKo

[LifeScienceAlliance @LSAjournal]

A zebrafish knockout model of the N-terminal acetyltransferase Naa80 demonstrates that this enzyme is required for actin N-terminal acetylation and normal inner ear development. @medofak_uib @OMRF @NAT_machinery @varshneylab @rasmusree https://t.co/nM7YBpjOwJ

[The EMBO Journal @embojournal]

The dynamics & functional impact of tRNA repertoires during early zebrafish embryogenesis
@ddnedialkova et al @MPI_Biochem find increased translational activity during maternal-to-zygotic transition sensitizes maternal mRNA decoding rates to tRNA supply
https://t.co/ouicOBWXCl

[ZEBRALille @LilleZebra]

@ritafior @ChampalimaudF @TheSFPM Wow. That’s so great. Congratulations to the team!

[FiorLAB @ritafior]

🚨NEW study from our LAB showing the predictive value of Patient-derived Breast Cancer 🐟zebrafish Avatars ! A co-clinical study where we compare the patient clinical response to treatment with their matching 🐟zAvatar! ✨100% @ChampalimaudF @TheSFPM
https://t.co/XTlfR8GE1W

[Development @Dev_journal]

Gα13 controls pharyngeal endoderm convergence by regulating E-cadherin expression and RhoA activation

Read this #OpenAccess Research Article by Bo Hu, @FangIowa & colleagues:

https://t.co/5fk6pjcszB

[EMBO Reports @emboreports]

SCAR-6 elncRNA locus epigenetically regulates PROZ and modulates coagulation and #vascular function. #epigenetics

-> https://t.co/JxrDCqO3HB

[GYAN RANJAN @gyanranjan2197]

📢New Preprint alert!🚨 Excited to share my PhD work!
SCAR-6 elncRNA locus epigenetically regulates PROZ and modulates coagulation and vascular function.
https://t.co/nyiGdHqp74
from @sridharsivasubb @vinodscaria lab @IGIBSocial
#lncRNA #vascular #zebrafish #coagulation

[Junsu Kang @JunsuKang2]

Great collaboration with Dr. Duong and Dr. Murphy. Also, thanks to Anjelica Rodriguez-Parks for her effort in establishing CUT&Tag in my lab and contributing to this research.
https://t.co/wf3qGUlTlr

[Gaurav @varshneylab]

Interesting review by @Lau_E_Sanchez: "Knockout, Knockdown, and the Schrödinger Paradox: Genetic Immunity to Phenotypic Recapitulation in Zebrafish" (https://t.co/rPvQADOW8K):

Phenotypic discrepancies between zebrafish knockouts and knockdowns aren't as wide as once believed!

Maternal gene contributions can mask zygotic mutations, creating unexpected outcomes in zebrafish phenotypes and introducing the concept of "Schrödinger genes"—where genes may exhibit conditional phenotypes!

Morpholinos (MOs) still have a role in zebrafish research, but their off-target effects require strict controls. Pairing MOs with CRISPR tools offers a powerful combination for understanding gene function!

Graded maternal contributions lead to phenotypic variability, complicating results in knockout models. Both maternal & zygotic inputs must be considered for accurate gene function studies!

"Susceptible," "Immune," & "Schrödinger" genes—categorizing phenotypes based on maternal-zygotic interactions.

[richard white @whitefishlab]

Embryo cells differ a lot from adult cells - but why? In a new paper from the @NorthTrista lab, they show that embryonic blood stem cells use mitophagy, which the adults do not. A great combo of #zebrafish and iPS cells (two systems I love) to show relevance from fish to humans.