I am very thrilled that I received the Travel Award and Merit Award of ISSCR 2023. Many thanks to the society and my lab @ISSCR@ScaddenLab I would like to share my work if you step by poster 1051. #ISSCR2023
I am very pleased to share our new 'MITOMICS' work exploring mitochondrial protein function and pathogenesis published today in @Nature. A great collaborative effort with @Coon_Labs, and the groups of Rob Taylor, Nurten Akarsu, and Mark Craven. https://t.co/35QWmaaIch
Now published in @LeukemiaJnl.
We found that the combined inhibition of LSD1 and JAK-STAT synergistically targets Down syndrome-associated myeloid leukemia at its core
👇👇
https://t.co/ectMRpV2uH
We ALSO note that, since heritable states are shared by closely related cells, we can measure multiple features (e.g. RNA & ATAC) separately in single cells from a clonal population, and tether them retroactively via lineage relationships. (3/12)
Excited to share our most recent publication @CellStemCell. Unexpectedly, we found that hematopoietic stem cells act as antigen presenting cells! Antigen presentation safeguards the integrity of the stem cell pool and prevents the onset of leukemias
(1/8).https://t.co/uQt3k1L4VL
Our Spotlight with @DohunKim96@MolecularCell highlights exciting work from @PerrimonLab revealing that fruit flies deploy lysosomal-derived cysteine to promote the TCA cycle and keep mTORC1 suppressed for surviving nutrient scarcity. https://t.co/GLlsq7WwkI
Today marks #AMLWorldAwarenessDay as we look to build awareness of #AML across the UK of this terrible illness.
Did you know acute myeloid #leukemia (AML) is an aggressive #cancer of the blood 🩸 & bone marrow, and makes up about 1% of cancers?
We are excited to see our story in the final format. Thank you so much @CD_AACR, and the wonderful team, @ADurbinLab@KStegmaier_DFCI, Dr. Tom Look work on this exciting project with us for three years. Thanks again to @AlexsLemonade for the support.