Giulia Schiroli

Passionate about hematopoiesis and gene editing. Exploring biotech life. Postdoc @ScaddenLab, MGH/Harvard. PhD @NaldiniLab, SR-TIGET.

[Kamila Naxerova @naxerova]

https://t.co/bubWBahnEb

[Justin Eyquem @j_eyquem]

I am so excited to share our new paper in @Nature: the first programmable, site-specific integration of a large DNA payload into T cells in vivo.
A single IV injection results in therapeutic levels of TRAC-targeted CAR T cells in multiple models.

https://t.co/t3pyjHyGWS

a 🧵

[Vijay Sankaran @bloodgenes]

Delighted to have our work on 🧬 resilience to 🩸cancer led by @GauravA_UK & amazing collaborators, including @KharasLab, published in @ScienceMagazine: https://t.co/lZDCy8CSBv 🧵

[Anastasia Conti @anastasiaconti5]

🚀 Our latest publication is out! I am grateful to @DiMiccoLab for giving me the opportunity to work on this challenging project, where I literally put 100% of myself. Huge thanks to all our coauthors.

👉 Read more here: https://t.co/QT82o25Mt6

🧬The best is yet to come!!

[Samuele Ferrari @ferrari_sam93]

🚨 What if a single DNA typo could inflame the body and outcompete healthy blood cells?

🧬 This happens in #VEXAS syndrome. In our paper out today in @NatureMedicine we show how.

📖 Here: https://t.co/tnLCb1bv3Y

👇 A story of inflammation, clonal warfare and #CRISPR editing 🧵

[Eric Vallabh Minikel @cureffi]

Introducing CHARM: a new epigenome editor to methylate DNA at the promoter of a targeted gene.
Our lab's collaboration with @JswLab's @EdwinNNeumann & @TessaBertozzi shows deep silencing of brain PrP

Paper: https://t.co/HZRKk2m1b2

Blog: https://t.co/crVVYpyI6w

[Sébastien Levesque @SbastienLevesq4]

My postdoc work in the @danielevanbauer lab is out @NatureBiotech! We found that the limited nucleotide pool in hematopoietic stem and progenitor cells (HSPCs) constrains reverse transcription and thus prime editing (PE). https://t.co/SultcbhT21

[Giulia Schiroli @GiuliaSchiroli]

particularly grateful to @fabianamduarte and @vkartha88 for the long journey shared together!

[Giulia Schiroli @GiuliaSchiroli]

Finally out!
Great collaboration @ScaddenLab @JD_Buenrostro
Epigenetic heterogeneity of the clone of origin shapes phenotypic responses in clonal hematopoiesis - we uncover a Sox4-high state that predisposes Tet2 mutant clones for dominance.
@NatureComms
https://t.co/cL9zXWwn8w

[Franco Izzo @FrancoIzzo85]

GoT-ChA!

I am thrilled to announce that our paper "Mapping Genotypes to Chromatin Accessibility Profiles in Single Cells" is now out in @Nature !!

👩‍🔬👨‍🔬🧬If you want to link somatic mutations to epigenetic changes directly in patient samples:

https://t.co/M9Y3wEvpuW
👇🧵

[Jennifer Trowbridge @TrowbridgeLab]

Thank you, Connie, for your pioneering work in hematopoietic stem cell biology, for being an inspiration to us women in science, for your vision, your mentorship, your kindness. The legacy and impact of your ideas and research will live on and never be forgotten ❤️

[Mount Sinai Tisch Cancer Center @TischCancer]

We look forward to hearing from @_ruslansoldatov @MSKCancerCenter on Feb. 1. Hosted by @PapapetrouMDPhD @IcahnMountSinai

[Giulia Schiroli @GiuliaSchiroli]

New Orleans here we come! Looking forward to great science #ASH22 https://t.co/2D1I96ArhA

[Fyodor Urnov @UrnovFyodor]

This is a tragedy.
The way to honor the memory of the brave human who passed away is to learn as much as we can from this to inform the development of safe and effective genomic therapies for devastating disease. @laura_ungar
https://t.co/cIFhVe19mx

[Miccio lab @LabMiccio]

Thrilled to share with you our study published in Nat Comm on base editing strategies for hemoglobinopathies and the superior performance of ABE vs CBE in hematopoietic stem cells!
A great thank you to all the members of the lab and our collaborators!
https://t.co/oMvD2oLTJ9

[Ben Kleinstiver @BKleinstiver]

Register for this *FREE* virtual symposium with a stellar lineup of pioneering speakers!
Come learn about the challenges & progress in the gene editing field!!
🧬🔧🎖️
@lab_davidson @skathire @davidrliu & many others!

[Samuele Ferrari @ferrari_sam93]

Finally out in @CellCellPress our latest work on #CRISPR #gene #editing in hematopoietic #stem cells by @NaldiniLab and particularly @o_attya and @GabriPedrazzani! Big kudos to everyone!

@SanRaffaeleMI @Telethonitalia @MyUniSR

https://t.co/J7Zrz8cS5h

[Tessera Therapeutics @TesseraTx]

Today we announced over $300M in Series C financing partnering with a group of world-class investors that will support our pursuit to revolutionize genetic medicine. Read about our #GeneWriting platform and its potential to cure diseases at their source: https://t.co/JuBF6GkUhv

[youmna kfoury @KfouryYoumna]

A huge team effort under the umbrella of the Boston bone metastases consortium. Targeting CCL20:CCR6 axes relieves immunosuppression in bone met prostate cancer. @ScaddenLab @KharchenkoLab @SykesLabMGH @MGH_RI @Cancer_Cell https://t.co/hYn7AsjiJa

[Andrea Capocci @andcapocci]

Dal dipartimento di fisica della Sapienza.