mihir metkar

[mihir metkar @MihirMetkar]

@sainiharleen @mooreorless62 @ChristophPepin Thanks, Harleen!

[mihir metkar @MihirMetkar]

Delighted to share our new review "Tailor made: the art of therapeutic mRNA design," co-authored with @mooreorless62 and @ChristophPepin. We explore the fascinating interplay between mRNA sequence & structure in mRNA medicine. #mRNA #therapeutics #mRNAdesign

[Nature Reviews Drug Discovery @NatRevDrugDisc]

Tailor made: the art of therapeutic mRNA design https://t.co/R7w3gBDjoy

Find out how nucleotide sequence, nucleotide modification and RNA structure interplay to affect translational efficiency and mRNA stability in this review by @MihirMetkar @ChristophPepin and @mooreorless62

[Emiliano Ricci @emi_aeruginosa]

Congratulations for this tour de force! @CenikLab https://t.co/7twv2QqZE0

[Emiliano Ricci @emi_aeruginosa]

Great work from @castello_lab characterising the “in virion” RBPome of HIV-1! I am glad we could help! Incorporation of genome-bound cellular proteins into HIV-1 particles regulates viral infection https://t.co/euaVnO3Nim

[Green Lab @GreenLabJHMI]

The Green lab is looking to hire a postdoc to study ribosome stalling and rescue in bacteria! See our official posting (link below) for details.

https://t.co/lNpDTxzHsz

[Sandhya Ganesan @SandhyaGansan]

IISER TVM is accepting applications for Ph.D. and Integrated Ph.D. programmes for the Varsha 2022 semester starting in August. Apply before May 21! https://t.co/ZJuYHB7GOj
https://t.co/YfsK98Ymu7
Candidates interested in infection biology, please check- https://t.co/OW0ZUhVtvf

[Vahbiz Jokhi @VahbizJ]

This is all I want! "I don’t want commiseration, I want a shot. Right in my daughter’s fat little thigh. Jabby-jab."
https://t.co/Vjuvj1o4rJ

[National Academy of Sciences @theNASciences]

Job Dekker of @UMassChan has been elected to the National Academy of Sciences for outstanding contributions to genomics. Dekker is also a member of @theNAMedicine.

Read more: https://t.co/XNcPE2mA80 #NAS159

[Alper Kucukural @nephantes]

Melissa’s Ted talk https://t.co/UEzvnNxZhi

[Matthew Taliaferro @JMTali]

Excited to share our newest manuscript! We find that RNA localization mechanisms that send RNAs to a given subcellular structure in one cell type can *predictably* traffic RNAs in other cell types, even if they don't have that subcellular structure. https://t.co/YKTVI1w2Cs

[Danny IncaRNAto @incaRNAtolab]

Friends don't let friends use ML-based methods to predict #RNA structures 😊 https://t.co/tKsjNfQoyD

[Kathrin Leppek @KatLeppek]

Published today: Combinatorial optimization of mRNA structure, stability, and translation for RNA-based therapeutics. https://t.co/3OBdX8jyR1 @NatureComms 🎉

[Dmitri Ermolenko @DmitriErmolenko]

Our new study, which is out in Nat Comm https://t.co/ZYUpK2FQFm, shows that contrary to prevailing dogma, specific length and structure, rather than high stability, enable regulatory mRNA stem-loops to pause translation. This work was led by a talented PhD student Chen Bao.

[bioRxiv @biorxivpreprint]

2'-O-methylation of the second transcribed nucleotide within mRNA 5' cap impacts protein production level in a cell specific manner and contributes to RNA immune evasion https://t.co/pi2QQR3Gp3 #bioRxiv

[Kathryn Lilley @lilley_ks]

We can now obtain subcellular maps for both RNA and protein in the same experiment and show the dynamic changes in location of both in the unfolded protein response. Introducing LoRNA (the LOPIT for RNA) https://t.co/wehbHIYLCu

[Korostelev Lab @KorostelevLab]

Hot off the press, "Time-resolved cryo-EM visualizes ribosomal translocation with EF-G and GTP": https://t.co/w9qu5oOmKH
We used cryo-EM – without inhibitors – to capture how mRNA and tRNAs move through ribosome to make proteins. Congrats @seussofscience, @Demolab6, @YaMingHou1

[UMass Chan Medical School @UMassChan]

The coloring book that the ScienceLIVE team at UMass Chan created to teach kids about the mRNA vaccine is now available for free in English and Spanish here: https://t.co/lpEGNlLsFg

@DrAngelaMB @ScienceLIVEUMMS @UMassMedRTI @UMassChanLib @worcesterpublic @BostonSchools

[Jon Watts @jwattsgroup]

Oh yeah. @UMassMedRTI

[mihir metkar @MihirMetkar]

@rupavr @DBT_NCCS_Pune @rajesh_gokhale @DBTIndia @IndiaBioscience @Sci_Rio Thanks, Rupa!