๐ New tool out! LIVIA (Local Interaction Visualization and Analysis) โ a browser-based tool for assessing and visualizing predicted protein-protein interactions.
Drop in a prediction from AlphaFold-Multimer, AF3, ColabFold, Boltz-1/2, Chai-1, or OpenFold3 (ZIP or folder, auto-detected) and LIVIA answers the two questions you actually care about:
โธ Do these proteins interact?
โธ Which residues form the interface?
What you get:
โธ Interface confidence scores โ iLIS (our local metric), ipSAE, actifpTM, ipTM
โธ Interaction interface heatmaps (PAE, LIS, cLIS)
โธ Sequence viewer + linear & circular contact maps highlighting Local Interaction Residues (LIR) and contact LIR (cLIR)
โธ Embedded Mol* 3D viewer
โธ Downloadable ChimeraX & PyMOL scripts
Also fetches dimers directly from the AlphaFold Database โ adding the interface annotations AFDB doesn't provide.
Everything runs locally in your browser. No install, no upload.
LIVIA started as a personal tool โ I built it with Claude Code and used it to make every structure figure in our FlyPredictome preprint (Kim et al., 2026). (Claude Code is truly insane...) Along the way I realized it could be useful for others, too.
If you have a favorite color palette for structure visualization, please let me know โ happy to add it as a preset ๐จ
๐ LIVIA tool: https://t.co/qSaedW3yka
๐ iLIS / batch CLI: https://t.co/jYN3yg3l6a
๐ LIVIA preprint: https://t.co/uHwEbAMBGH
๐ FlyPredictome preprint: https://t.co/O3mAOzF2GD
New paper: A collection of split-Gal4 drivers targeting conserved signaling ligands in Drosophila
Ben Ewen-Campen, Neha Joshi, Ashley Suraj Herman, Tanuj Thakkar, Jonathan Zirin, Norbert Perrimon
doi: https://t.co/ro7tJYoWsJ
Sensing of dietary amino acids and regulation of calcium dynamics in adipose tissues through Adipokinetic hormone in Drosophila
Muhammad Ahmad, Shang Wu, Xuan Guo, Norbert Perrimon, Li He
bioRxiv 2024.03.04.583442; doi: https://t.co/Kij55HRVSp
This years Drosophila service award goes to the yeoman efforts over many decades by the leadership and staff of the Bloomington Drosophila Stock Center; no fly lab exists that does not owe them a huge debt of gratitude ๐ congrats all!
Interested in doing Ca2+ imaging at the fly NMJ? Excited to have this protocol out detailing GCaMP8 imaging at pre- and post-synaptic compartments, check it out!
https://t.co/nqwXwQJ9YQ
We are releasing a whole-brain connectome of the fruit fly, including ~130k annotated neurons and tens of millions of typed synapses!
Explore the connectome: https://t.co/EWcwRiO0Oz
Reconstruction paper: https://t.co/wCI3hASUfD
Annotation paper: https://t.co/3bPTNK9hRk
1/6
Mind-blowing ๐คฏ๐คฏ๐คฏ
@SfNtweets Executive director of SfN: Salary $751,996/yr, working 35 hours per week!
I guess now you know where your Abstract submission fees & Membership fees have been going?
Hey, Postdocs, What is your salary and how many hours do you work?
Really excited to share this new preprint on automated microinjection of Drosophila and zebrafish embryos! See this thread by our collaborator @bksuhasa