Nick

[The All-In Podcast @theallinpod]

Friedberg: New study shows enzyme reverses skin age from 70+ years to 31

Chamath: That’s a $2T market.

Did Scientists Just Discover How to Reverse Skin Aging!?

“CML is kind of the predominant molecule that gets formed in this extracellular matrix that's driving aging, and nothing breaks it down.

So these scientists set out to try and create an enzyme, an enzyme is a protein that breaks something down, that can break down CML.

And so these guys kind of went out and they took the target, which is CML, and tried to figure out, ‘Okay, how do we actually degrade CML, clear that extracellular matrix, and reverse aging?’

They started to test it on the proteins that we would find in our body, casein, collagen, retinal proteins, which are in your eye, hemoglobin, and they were able to get rid of 52 to 97% of the CML, just degrade it away.

And then they found several sites where they were able to degrade over 90%.

And then they took actual human skin from elderly patients that had donated their skin, and they put this enzyme onto that skin, and they were able to eliminate 55% of the CML on the skin, basically reverse the skin's age down to the age of a 31-year-old, this is from greater than 70-year-old patients, just by putting this enzyme on the skin.

And so it's kind of a groundbreaking demonstration of combination of AlphaFold, what's called directed evolution, where you change the order of the DNA that changes the structure of the protein to test different proteins, do high throughput screening, and ultimately make a novel protein that doesn't exist in nature today that can do something pretty profound for human health.”

Chamath:

“It will be a trillion-dollar market. If you can create a cream…”

Friedberg:

“I mean, dude, if you could put this enzyme literally on your skin and have it absorb in…”

Chamath:

“Game over. That alone is $2 trillion.”

[Nick @ncoronado21]

@SecDuffy @boringcompany @USDOT Minimum regulation to verify safety and then let people build!

[Nick @ncoronado21]

@Tony_BATtista @tastyliveshow Thanks to you and Tom for all the advice over the years. Changed my perspective on investing. @tastylive is gone.

[Nick @ncoronado21]

@JCChristopher @AvLawns How many kwH per month do you average?

[Nick @ncoronado21]

@cybrtrkguy @RonDeSantis Charging at home is also great, never going to a gas station.

[Nick @ncoronado21]

The collaborative Turing test.

If 5 humans can't identify 5 AI teammates after 1 month of remote work, Digital AGI is achieved.

https://t.co/qhnmUqpomF

[Nick @ncoronado21]

@elonmusk This is proof that Washington is unsalvageable. AGI or bust.

[Nick @ncoronado21]

@SawyerMerritt Waymo allegedly has 25 vehicles operating in Austin.

[Nick @ncoronado21]

@SawyerMerritt Needs some @boringcompany tunnels with autonomous cybercabs transporting people.

[Nick @ncoronado21]

@nerdalert The best electric truck that no one wants. Too weird looking for most people and cost/ range is much worse than 2019 demo.

[Nick @ncoronado21]

@karpathy What about revenue/employee?

[Nick @ncoronado21]

@jeremyjudkins_ Cybertruck needs the 2019 range/prices.

[Nick @ncoronado21]

@sushantkumar67 Here's what I want:

250 miles (3.5 hours) at 75 mph from 80% to 20%, 10 minutes to recharge 20% to 80%.

Current Model Y performance:

150 miles (2 hours) at 75 mph from 80% to 20%, 25 minutes to recharge 20% to 80% at V4 supercharger.

[Nick @ncoronado21]

What does the Tesla community think of this? Real or hype? Will Tesla have a similar breakthrough in charging speeds?

https://t.co/7335lDjNTZ

[Nick @ncoronado21]

@HansCNelson @MarkRober @elonmusk What was the vehicle in the video that was using LIDAR and how much does it cost? That's an important question. Eventually FSD should incorporate non visible spectrum cameras to help with weather.

[Nick @ncoronado21]

@Jason We already pay capital gains on crypto. The government should purchase Bitcoin with these taxes only.

[Nick @ncoronado21]

@kimmonismus Hallucination rates still seem too high for trustworthy agents.

[Nick @ncoronado21]

@DaveShapi This has always been my definition since reading The singularity is near in 1999. ASI can breakthrough on all the places that humanity is stuck. Unified gravitational model etc.

[Nick @ncoronado21]

@DaveShapi Claude message limits are too frequent for it to be useful.

[Nick @ncoronado21]

@TeslaTruckClub @elonmusk We should provide ample severance.