ninjaaaaainny

TB enthusiast. CRISPR guru wannabe. Former member of @RockLabTB

[James Chen @JamesChenPhD]

New preprint! We combined pooled-AlphaFold3 with functional genomics to map ~1.3M protein interactions across a mycobacterial proteome, revealing functions for dozens of essential genes and providing a scalable framework to decode bacterial biology.

https://t.co/qWnZBwVIGX

[Rockefeller University @RockefellerUniv]

Rifampicin, the main treatment for TB, is losing ground against drug-resistant bacteria. A new study from @RockLabTB and Liz Campbell in @NatureMicrobiol finds that pairing rifampicin with a second inhibitor dramatically boosts the potency of both drugs.
https://t.co/Nk3l6o1MdH

[Nature Microbiology @NatureMicrobiol]

Out Now! Transcription co-inhibition alters drug resistance evolution and enhances Mycobacterium tuberculosis clearance from granulomas https://t.co/rrJ6El3l0v #MycobacteriumTuberculosis #DrugResistance #Antibiotics

[Rockefeller University @RockefellerUniv]

Rockefeller's Svetlana Mojsov is a recipient of the 2024 Lasker~DeBakey Clinical Medical Research Award! Congratulations 🎉 @LaskerFDN

[Rockefeller University @RockefellerUniv]

Rockefeller's Elizabeth Campbell has been named professor and Head of Laboratory! The infectious disease specialist will continue her groundbreaking work on the transcriptomes of the pathogens behind tuberculosis and Covid. https://t.co/3I2wuQGgLG

[Kathryn Eckartt @kae_eckartt]

Proud to share our work out now in @Nature https://t.co/W6ZCQEyLST! In an amazing collaboration w/ Liz Campbell & Maddie Delbeau @DarstCampbell we identify the/a source of the fitness cost of rifampicin resistance (RifR) in Mtb and how some compensatory mutations rescue the cost!

[LiuLab_Rockefeller @InLiuOfBulkExps]

Check out this nice news piece @RockefellerUniv on our recent Mtb SEnd-seq paper! Congratulations again to all the co-authors @ninjaaaaainny1 @RubyFroom @DarstCampbell @RockLabTB 🎊🍾🎉

[Rock Lab 🧬🧫 @RockLabTB]

TB ≠ E. coli. Well done Xiangwu! This was a wonderful collaboration with our dear friends @InLiuOfBulkExps and @DarstCampbell
https://t.co/UEERazjjoa

[Bo Xia @BoXia7]

A true curiosity-driven journey, fulfilling one of my childhood dreams! The tail loss marks a pivotal evolutionary step towards humans and apes. But how did it happen? https://t.co/jTcOAH0Fcs @ItaiYanai @JefBoeke

[Rock Lab 🧬🧫 @RockLabTB]

We’re looking to hire a bioinformatics assistant. Lots of fun stuff to do. Apply below if interested!

https://t.co/7lgZuQJl8a

[Rock Lab 🧬🧫 @RockLabTB]

The final act of @nickpoulton6's PhD work. A remarkable run by all accounts.
https://t.co/NvyXQNXvSB

[Yuyang Liu @YuyangLiu1996]

(Thrilled to have my first Twitter Thrill) Thrilled to share my first paper published today ⁦@ScienceMagazine⁩. How does a cell monitor metabolic homeostasis across so many subcompartments? We tried to offer a hint by looking at GSH in mitochondria. https://t.co/BjEkfL7Ey1

[Ben Kleinstiver @BKleinstiver]

We’re excited to share our work developing a new gene editing approach that we’re calling #clickediting 🖱️✴️🧬.

Click editors (CEs) utilize DNA-dependent polymerases to write bespoke edits into the genome. https://t.co/E6DOZD1CWp
@CGM_MGH @MassGeneralNews @MGH_RI @harvardmed

[Yisui Xia 夏乙燧 @YisuiXia]

Glad to share our KL lab recent work on @ScienceMagazine about DONSON orthologues are essential for CMG assembly during initiation in C. elegans🪱, by a nice collaboration between us @mrcppu, @Yeeles_Lab @MRC_LMB, Ye and Constance @UoDLifeSciences
https://t.co/qFpykA5ogV

[Feng Zhang @zhangf]

Delivery of therapeutic molecules is a major bottleneck for treating a wide range of diseases. Today we describe a new modality for delivering proteins based on an engineered contractile injection system @nature https://t.co/eIAn8MW6jN

[Jason Mast @Jasonmmast]

20 years ago, a young New Zealand bacteriologist looking for ways to kill pests found microbes with some shocking abilities. Few paid attention.

Today, Feng Zhang has turned it into a powerful tool that may overcome the biggest hurdle in genetic medicine

https://t.co/hCvZSoBe5w

[HWeinstein-Lab @HWeinsteinLab]

Hengyi Xie @HWeinsteinLab developed a powerful analysis of ligand-induced conformational rare events underlying the functional dynamics of the cell component protein that shuttles cholesterol (CHL) to membranes with low CHL content. Excellent example of allostery in action.

[Shan-Lu Liu @ShanLuLiu1]

A wonderful piece by @jeffmervis Pall of suspicion: NIH’s secretive ‘China initiative’ has destroyed scores of academic careers https://t.co/SIEqBQukl0

[Trevor Bedford @trvrb]

I've written before that #COVID19 has no evidence of genetic engineering and the "bioweapon" theory has no grounds. See, for example https://t.co/aR5NfTJzYq. In this thread I wanted to directly address the theory of escape from lab in Wuhan. 1/21