NPC-aficionado

Let's discuss #nuclearpore science!

[NPC-aficionado @NPC_aficionado]

https://t.co/fYomNuMdT2 👀👀👀

[Yasuhiro Hirano @yasuhhirano17]

Thrilled to share my first preprint!
https://t.co/ksg8Y4Jq20

We addressed the question of how the nuclear envelope integrity is maintained from various damages and found that Bqt4 is involved in this process by recruiting phosphatidic acid.

[NPC-aficionado @NPC_aficionado]

Off-topic - but: Nature is amazing!

[Lea Lab @LeaLabTweets]

Reducing the complexity of a fascinating molecular motor. Read our Behind the Paper blog, where we detail our journey to deciphering the structural basis for how bacterial flagella shift into reverse gear: https://t.co/ki0UnetrIw

[NPC-aficionado @NPC_aficionado]

Giant cargo opening a large enough hole through the nuclear envelope by breaking the scaffold of the #nuclearpore

[Beck Laboratory @Beck_Laboratory]

In a great collaboration with @HummerLab and the Kräusslich lab, @jpkreysing, @MaziarHeidari1, @VojtechZila and others tackle what happens when HIV capsid goes through an NPC. Instead of the NPC cracking the capsid, the capsid appears to crack the NPC (@MPIbp @CiidHeidelberg).

[Andrej Sali lab @salilab_ucsf]

Proud to share the result of an amazing collaboration with Javi Fernandez-Martinez, @RoutLab_RU , and @TheVillaLab ! https://t.co/UslJWdFKIW Congrats to @dgvjayS @neeleshsoni03 @JoshHutchings94 @ig_ech and the team!
And check out the video by @neeleshsoni03 ! #NPC

[NPC-aficionado @NPC_aficionado]

Back with a cool paper from the @Beck_Laboratory showing that NPCs lacking Nup133 are quite messed up! Aberrant symmetries (7 and 9) and incomplete outer rings! Suggests that the outer rings are major safeguards of the 8-fold symmetry.

[Reiya_Taniguchi @Reiya_Tan1guch1]

Happy to finally share our preprint about NPC scaffold integrity and its perturbation! Could not have been achieved without all the helps from co-authors and colleagues in @Beck_Laboratory, especially Martin and our collaborator @DoyeValerie.
https://t.co/IembfQCyNq

[NPC-aficionado @NPC_aficionado]

@Bahmanyarlab: Nuclear envelope assembly relies on CHMP-7 in the absence of BAF-LEM-mediated hole closure https://t.co/ks9Ancz3nf

[NPC-aficionado @NPC_aficionado]

@treybolyard @bielleogy https://t.co/276rDIgrFP

[NPC-aficionado @NPC_aficionado]

The link between mitotic progression defects and the interaction with ELYS is intriguing but remains to be shown.

[NPC-aficionado @NPC_aficionado]

Kehlenbach et al. detect a mitosis-specific interaction of ELYS with the ER-membrane protein VAPB and implicate VAPB in mitotic progression https://t.co/tPmG29Xc7s

[conti_lab @LabConti]

Our new study exploring the molecular principles governing packaging of eukaryotic mRNPs has just come out in @GenesDev .
We find evidence for RNA packaging and compaction relying on positively charged IDRs of potentially many RNA binding proteins. Interested? Check it out!

[Journal of Cell Biology @JCellBiol]

.@LeeShoken @JakeCarrasquil1 @HollyMerta & @Bahmanyarlab report that the nuclear envelope adapts to changes in #lipid #metabolism - direct sensing of the local membrane environment by an amphipathic helix in Sun2 contributes to its retention and stability. https://t.co/Od7GwOjm9J

[Sanjeev Kumar Choudhry @sanjeevkchy]

I am excited to share our research published in @JCellBiol
Nuclear pore complexes mediate subtelomeric gene silencing by regulating PCNA levels on chromatin https://t.co/4hWAL8t9oI. 1/4

[maurizio molinari @MolinariLab]

TMX4-driven disassembly of LINC complexes and SEC62/LC3-regulated asymmetric autophagy of the Outer Nuclear Membrane (that we define as micro-ONM-phagy) ensure nuclear envelope dynamics upon acute ER stress. https://t.co/GYmgY1gRGg

[Rothstein Lab @Rothstein_Lab]

Nucleoporin foci are stress‐sensitive condensates dispensable for C. elegans nuclear pore assembly - from ⁦@Seydouxlab⁩ https://t.co/k5ZKNXwQ7l

[Lammerding Lab @LammerdingLab]

Do amoeba have lamins? How do they compare to metazoan lamins? Working with Ralph Gräf, who discovered a lamin-like protein, NE81, in dictyostelium, we compared the ability of NE81 and human lamin A to rescue nuclear defects in lamin deficient cells:
https://t.co/UihI81F6wt

[NPC-aficionado @NPC_aficionado]

Cryo-EM structure of pre-60S particles trapped in purified yeast nuclear pore complexes
https://t.co/5pOl8jj1jo

[NPC-aficionado @NPC_aficionado]

Beautiful work by @HiralABShah and the Dey lab @Dey_Gautam. And those #nuclearpore arrays are really pretty! Looking forward to more on those! https://t.co/uirXEnUI0N

[Sumin Kim @suminkim28]

Excited to share my thesis work!

Using super-resolution microscopy and a new HaloTag-Nup107 mouse line, we find that 1) NPC biogenesis is upregulated during neuronal maturation and that 2) torsinA is essential for normal localization and assembly kinetics of neuronal NPCs. (1/N)

[bioRxiv Cell Biology @biorxiv_cellbio]

Nuclear growth and import can be uncoupled https://t.co/WY9TCk9DJg #biorxiv_cellbio