OserLab

OserLab @DanaFarber @harvardmed Seeks To Identify New Targeted Therapies For Small Cell Lung Cancer. Tweets/Views are my own.

[Lauren Averett Byers, MD @LaurenByersMD]

10th Anniversary!! of #SCLC U24 NCI Consortium meeting at @theNCI with @charlesrudin @PTRUJH Dr. John Minna Dr. Trudy Oliver @UTMDAnderson #SCLC #LCSM @UTSWCancerBio @NIH #plasticity #PDXs #SCLCsubtypes @SageJulien

[OserLab @Oser_Lab]

Excited to share our latest preprint, a wonderful collaboration w/ Matt Freedman and Sylvan Baca’s labs. Leveraging cfChIP-seq from patient plasma + functional mouse modeling, we uncover how TF subtype shapes response and resistance to tarlatamab in SCLC.
https://t.co/4nKW8PKe4D

[Sylvan Baca MD PhD (Hiring!) @SylvanBacaLab]

Our latest collaboration with #MattFreedman and @Oser_Lab on resistance to tarlatamab: https://t.co/3Ei2gYY3Gm. An exciting framework for studying cancer resistance: observations from patients using epigenomic #LiquidBiopsy -> functional validation in mouse models.

[OserLab @Oser_Lab]

It was wonderful visiting the Northwestern BMG Department today and learning about all the outstanding science going on here. Thank you @LuWangLab for the invitation!

[Northwestern BMG and SQE @NU_BMG_SQE]

Join us today for the BMG Seminar Speaker Dr. Matthew Oser! @Oser_Lab Hosted by Dr. Lu Wang @LuWangLab #epigenetics #Cancer #LungCancer @NUFeinbergMed @NorthwesternMed @DanaFarber @harvardmed

[OserLab @Oser_Lab]

Grateful to all of our collaborators including @yejingge at MDACC.
https://t.co/L6KF3PkMgy

[OserLab @Oser_Lab]

Excited to share our new work in Dev Cell (https://t.co/BjVkuDiBXi), led by my highly talented postdoc Deli Hong! We find that loss of NOTCH2 creates a dependency on TRIM28, highlighting TRIM28 as a potential therapeutic target in NOTCH2-deficient or low-NOTCH2 SCLC.

[OserLab @Oser_Lab]

@DrChoueiri @DanaFarber @Nature @DanaFarberNews @harvardmed @sands_jacob Thank you @DrChoueiri! Greatly appreciate your support and enthusiasm for this work!

[OserLab @Oser_Lab]

Please follow me on Bluesky: @matthewoser.bsky.social

[OserLab @Oser_Lab]

This study was led by my highly talented postdoctoral fellow Shilpa Singh and was an outstanding collaboration with Circle Pharma and Deepak Nijhawan's lab at UTSW. @DanaFarberNews @DFarberThoracic.

[OserLab @Oser_Lab]

Thrilled to share our new work published in Nature (https://t.co/6KIgZiDhMN). We report an exciting new potential therapeutic strategy with a fascinating mechanism of action for cancers with a compromised G1–S cell cycle checkpoint, including SCLC.
https://t.co/8UyaKWbecQ

[OserLab @Oser_Lab]

@triparnasen Congrats Triparna! That’s really great!

[Katherine A Donovan @kdonovan1008]

🧩 New paper out in Nature Communications!

"Unveiling the hidden interactome of CRBN molecular glues"
Huge thanks to our incredible team and collaborators who made this possible!
📖 Read the full open-access article here: https://t.co/iuTyDM24Vs

[OserLab @Oser_Lab]

This is the first year I’m riding the Pan Mass Challenge in 2 weeks! I’m riding in honor of both my parents. It will be a deeply meaningful ride for me. All proceeds go toward cancer research at Dana Farber. Please donate if you can (details/link below) https://t.co/kWqd3y1HVo

[LUNGevity Foundation @LUNGevity]

Great talk by Dr. Shilpa Singh @Oser_Lab @DanaFarber looking at Cyclin A/B RxL Macrocyclic Inhibitors in SCLC w/ high E2F activity. Beautiful example of bridging lab to clinical research. Phase 1 trial is recruiting. #SCLC25 @SclcSMASHERS

[OserLab @Oser_Lab]

@yejingge @CellCellPress @MDA_UTHGrad Congrats Yejing!!

[Jonathan Tsai @jonathanMtsai]

I am very excited to announce that I have started my lab at the Brigham and Women’s Hospital and Harvard Medical School in the Department of Pathology. We are seeking talented, curious, individuals and recruiting at all levels! https://t.co/rXEcDwQsPS
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[Dana-Farber @DanaFarber]

Thoracic oncologist Matt Oser @Oser_Lab, and scientist @CKadoch, @kadochlab at Dana-Farber have discovered a way to stunt the function of a driver of small cell lung cancer. The finding points to a potential treatment (cont) https://t.co/NAwOmSMuPz

[OserLab @Oser_Lab]

@DanaFarberNews @DanaFarber @CKadoch @BlavatnikAwards @NYASciences Congrats Cigall! Terrific news and so well deserved!

[OserLab @Oser_Lab]

@triparnasen @aliceb_phd @Sutherland_Lab @natasharekhtman @mkbaine @SandraOrtizCua @NarjustFlorezMD So great seeing everyone!

[OserLab @Oser_Lab]

@EllisLab_ Thanks Leigh. Hope you’re well!

[OserLab @Oser_Lab]

Thrilled to visit @MDAndersonNews next week and present some recent work from our lab on SCLC. Thank you @LeXiuning for inviting and hosting me!

[Xiuning Le MD PhD @LeXiuning]

I am excited to host Dr. Matt Oser from DFCI @Oser_Lab as our GrandRound speaker next week! Matt is a prominent physician-scientist, a colleague in thoracic oncology, a peer Damon-Runyon investigator, and a dear friend @DamonRunyon @LaurenByersMD @MDAndersonNews @EGFRResisters