Patrick Griffin

Postdoc @ Harvard HSCRB and the Broad Institute.

[Boris Cherny @bcherny]

People often ask what my biggest tip is for getting the most out of Claude Code.

These days my #1 tip is: use auto mode

Auto mode means no more permission prompts. It is the key building block for multi-clauding: start a session, then while it runs, work on another session in parallel.

[David Sinclair @davidasinclair]

Infinite Epigenetics & True Diagnostics acquire @sinclairfriends lab spin-out, Tally, giving them access to DNAme IP to help bring down costs & accelerate epigenetics-informed health care

Congrats to @L_Catterton, @melanie_goldey, @patrick_griffN, @gladyshev_lab & the entire team! 👏

[Rachel Savage @Rachel_E_Savage]

It takes two (transcription factors) to tango
Transcription factor collaboration enables precise T cell state engineering
https://t.co/UpHTANSeHD

Excited to share our preprint with @JD_Buenrostro, @cgersbach, and an incredible team of collaborators as part of @IGVFConsortium
🧵

[Surya Nagaraja @snaga13]

Excited to share my postdoc work with @JD_Buenrostro now out in @Nature!
"Epigenetic memory of colitis promotes tumour growth"
https://t.co/6703aeQlLG

We wanted to understand how transient inflammation can create a long-lived increase in cancer risk, even after full recovery 🧵

[Eric Topol @EricTopol]

First test of partial epigenetic reprogramming to reverse aging for two eye conditions (glaucoma and NAION) gets FDA go ahead
@lifebiosciences Based on 2020 @Nature paper https://t.co/7au101MazD
https://t.co/NAZCrVIz4V

[siddhartha jena @epijenatics]

Huge thanks to all co-authors and the inimitable
@JD_Buenrostro for supporting this new direction - I got to think about evolution, engineering, chromatin biophysics, and modeling during the course of this project. For more, check out the preprint: https://t.co/hMVuYLDZ3Y

[Andy Russell @AndyRusss]

Excited to share a short article I wrote describing: Slide-tags - which enables spatial single-nucleus sequencing, allowing us to dive deeper into the complexity of tissue organization. Grateful for the amazing team and support from @insitubiology and @macosko! #ToolsOfTheTrade

[Eric Topol @EricTopol]

The latest LLLM (large language of life) foundation model, with state-of-the art chronological age estimation, prediction of outcomes, and performance across different datasets and conditions

[zack chiang @z_chiang]

Introducing IN SITU GENOME SEQUENCING, a new technology to resolve DNA sequence🧬 and structure🔬

A team effort with @Andrew_C_Payne, @PaulReginato, @eboyden3, @JD_Buenrostro, and Fei Chen

https://t.co/2EcxBneYDn

This is how it works: (1/8)

[Jason Buenrostro @JD_Buenrostro]

Thrilled to see our ExIGS tool featured! A true testament to the power of collaboration. Huge congrats to the team for their hard work! 🧬@ajaylabade31 @z_chiang @CarolineComenho https://t.co/x6e5P3MfeW

[Alejo Rodriguez-Fraticelli @AlejoFraticelli]

Grades of DNA methylation as the basis of epigenetic cell memory... must-read.
https://t.co/MDBRTzp70c

[Tristan Tay @TristanTay1]

T cells become exhausted and fail to control tumors in cancer patients. What if we could replicate T cell exhaustion in vitro and uncover the gene regulatory network driving exhaustion, enabling immuno-oncology drug discovery? With AstraZeneca, the Buenrostro lab addresses this gap (https://t.co/BRC1tAHaWU):

[Brigham and Women’s Research @BrighamResearch]

Study Proposes Framework to Standardize Biomarkers of Aging and Accelerate Clinical Use @jpoganik
Read more: https://t.co/Sp62RzhXMt

[Jason Buenrostro @JD_Buenrostro]

We are recruiting postdoctoral fellows in neurobiology and development to complement our group specializing in genomic technologies, epigenetics and machine learning. projects are very well funded and we are interested in co-mentorship. Please DM if interested in hearing more!

[David Sinclair @davidasinclair]

Our latest paper is out - a new method called "TIME-Seq" to measure biological age for just a few dollars. Great work Patrick Griffin! @NatureAging Free download https://t.co/mXp6hNDCuO

[Patrick Griffin @patrick_griffN]

@ThomasJGriffin0 @BlackHarePress Huge congrats brother! 💪

[Alex Plesa @amplesa]

Can we reverse aging?
7 yrs ago, Ocampo et al. showed that partial reprogramming can ameliorate aging hallmarks. But, OSKM induction has safety limitations & no new factors have emerged since. Here, https://t.co/7ZXhqHYDAD we used 🧬 screens to find new rejuvenation factors🧵1/8

[Y. Ryan Lu @Y_Ryan_Lu]

Delving into our newly released result, a thread:

[Impetus @impetusgrants]

Can we shield the epigenome from age-related changes, much like how SIRT6 defends the genome? Using a CRISPRi screening approach, @XiaoTianPhD seeks to identify genes involved in maintaining epigenome stability. His new lab @sbpdiscovery is recruiting for various roles!

[Patrick Griffin @patrick_griffN]

Xiao is one of the most productive and kindest scientists I have ever met! Amazing opportunity

[Xiao Tian @XiaoTianPhD]

I am hiring multiple Postdoctoral Associates for my new lab at Sanford Burnham Prebys. We use a multidisciplinary approach (multi-omics, machine learning, long-lived species) to push the boundaries of aging research. Please see more details and apply here: https://t.co/BvZgxWoIvF