Pat Ward

Especially interested in metabolism, mitochondria and calcium. Postdoc w/ @VamsiMootha and endocrinologist @EndocrineMGH. Twin girl dad.

[Vamsi Mootha @VamsiMootha]

Our preprint is now published: In collab. w/ Ruma Banerjee we show how the B12 chaperone MMADHC spends its life in two cellular 'zip codes' dictated by the mitochondrial PMF (similar to PINK1). Co-led by @Sneha_Rath_, Zhu Li. https://t.co/5gv3sjinA4

[Relay Therapeutics @Relay_Tx]

New today: We’ve published a webinar focused on Vascular Anomalies education, intended to support broader understanding of the disease area, existing therapeutic options & ongoing clinical development of zovegalisib, our mutant-selective PI3Kα inhibitor. https://t.co/TEfOxgwKai

[Raghu Chivukula, MD PhD 🫁🧬🧠 @chivukula_raghu]

Why do some genetic mutations devastate specific tissues while sparing others?

We explore this question in GGC repeat disorders, revealing a mechanism linking protein aggregation to tRNA splicing failure in the brain.

🧵 on our new paper in Science:
🔗 https://t.co/a9rB53kRoS

[Pat Ward @patricksward]

@joshuagruber Any injuries?

[Lasker Foundation @LaskerFDN]

“As I look back on my ~60 years of biomedical research, I realize how important Serendipity was in shaping my career.” —#LaskerLaureate Joel Habener accepts the #LaskerAward. He is recognized for GLP-1-based therapy for #obesity.
#Lasker2024
@MassGeneralNews @harvardmed

[Pat Ward @patricksward]

@apatgir @NIH @ninds @EmoryUniversity @PharmChemBio @EmoryMedicine @Mito_News @Mito_Therapy @MitoResearch @cure_mito @MitOtalks @UMDF Congrats Anupam!

[Pat Ward @patricksward]

@VFCracan Congrats to all of you!

[HHMI @hhmi_science]

Congratulations to HHMI Investigator Vamsi Mootha (@VamsiMootha) of @HarvardMed and Navdeep Chandel of @NUFeinbergMed on being named recipients of the 2023 Lurie Prize in Biomedical Sciences by @FNIH_Org! https://t.co/YR0ekZoKrO

[Pat Ward @patricksward]

@JoseFlorezMDPhD @VamsiMootha @MGHMedicine @MassGeneralNews Congratulations, Jose!

[Relay Therapeutics @Relay_Tx]

#MarathonMonday is coming quickly, and we are ready to cheer for Relayers who are running #Boston127! Here, we spotlight Megan Bonney, Aaron Dy and Emily Ullmann who are each experienced marathoners. This will be marathon #9 for Megan, #10 for Aaron and #11 for Emily. Best of luck to all our Relay Tx runners!

[Pat Ward @patricksward]

@lydfinley @MSKCancerCenter My undergrad thesis was on AMPK, and a few weeks before my defense this paper came out from @DrRGJonesLab. Provided a completely different way of thinking about AMPK for me. Also, p53 being regulated by metabolism??? That's not what the textbooks said!
https://t.co/yiLFU4kkRZ

[Pat Ward @patricksward]

@LuLaboratory So incredibly sorry to hear about this, Chao. A huge loss.

[David R. Liu @davidrliu]

Today we report in @nchembio the discovery and molecular basis of the first reported subtype-selective cyclophilin inhibitors. This work was a collaboration with the labs of Markus Seeliger and @VamsiMootha.
https://t.co/zM9zYUbDUL
1/9

[Pat Ward @patricksward]

@MarcusDGon Endocrinologists always having to fight for respect.

[Pat Ward @patricksward]

@lydfinley @S__Baksh His 2nd best choice ever! Only surpassed by his choice of PhD mentor, of course.

[Pat Ward @patricksward]

@S__Baksh @MGHMedicine @mghmedres Congrats!

[Pat Ward @patricksward]

@lydfinley @Nature @paigearnold2 @__btjackson @GSKGradSchool @MSKCancerCenter Congrats on the great work! Also super glad to see that the deuterated 2HG standard lives on.

[Pat Ward @patricksward]

@VFCracan @AJPierik @thechaolab @VamsiMootha Congrats!

[Pat Ward @patricksward]

At least some of the papers were reproducible.

[Daniel J Drucker @DanielJDrucker]

@BrianNosek @OSFramework Academia is incentivized, from hiring to tenure to awards, to produce high impact papers in top Journals that demand the spectacular. Lack of reproducibly is rarely quantified or penalized. Pharma is rewarded for consistently reproducible data that enables an IND. Two solitudes

[Alexis A. Jourdain @jourdainlab]

Happy to introduce #uridinolysis - a metabolic pathway that supports growth on #uridine or #RNA, replacing glucose as a #carbon_source

https://t.co/ubIARa0xRx

Last piece of my work with @VamsiMootha @broadinstitute @MGH_RI @MGHMolBio @HHMINEWS @Harvardmed

A 🧵 please RT (1/9)