Leonid A. Pobezinsky

Immunologist, Associate professor at UMASS, Amherst

[Leonid A. Pobezinsky @pobezinsky]

New Immunology Summer Course Is Here!
We are excited to offer an upper-level summer course, Molecular Immunology (ANIMLSCI 572), at the University of Massachusetts. For students in biology, microbiology, and biochemistry. Fully online and asynchronous.

Help us spread the word!!!

[Jonathan Kipnis 🟦 @jonykipnis]

Since when did it become a norm that reviewers' comments are not shared with the authors of grant proposals? If you run a major foundation/agency and are not willing to share reviewers' comments, then your review process is likely dishonest. I decided that I will not be applying for grants if I cannot see a feedback. If only all of us did that, this horrible practice would cease immediately.

[Global Immunotalks @globalimmuno]

Looking forward to our next #globalimmuno talk this Wednesday, August 27th, at 9am PST, noon EST, 4pm GMT by Dr. Adrian Hayday.

Title: “Lymphoid stress-surveillance, normality sensing, and immunology”
ZOOM LINK: https://t.co/NLHvXAlCXS
LIVE ON YOUTUBE: https://t.co/oeHYAkRwGV

[Leonid A. Pobezinsky @pobezinsky]

A Dapl1+ subpopulation of naïve CD8 T cells is enriched for memory-lineage precursors | Science Advances https://t.co/hpxVRMVZyI
Proud of Adam Lynch & our team. We found that some naïve T cells are pre-programmed for stem-like memory fate even before antigen encounter.

[Leonid A. Pobezinsky @pobezinsky]

Congrats to our team! Curious about intraepithelial lymphocyte complexity? Check out our story in Frontiers in Immunology! Surprising results that shed new light on their heterogeneity. https://t.co/uEIKl78gGZ #GutImmunity #Tcells #IntraepithelialLymphocytes

[Dr. Catharine Young @DrCatharineY]

Scientific method: The systematic process for investigating phenomena: observe, question, hypothesize, experiment, analyze, conclude and repeat. It ensures findings are objective, repeatable, and evidence based.

[Waggoner Lab @LabWaggoner]

Cellular architecture is a predeterminant of early TCR signaling and subsequent cell fate decisions of individual naïve T cells in response to antigen @ScienceMagazine @BenHalePhD @BerendSnijder
https://t.co/rtwbRnkaD9

[Nature Reviews Drug Discovery @NatRevDrugDisc]

The first tumour-infiltrating lymphocyte (TIL) therapy for cancer could be approved by the FDA early next year, and a diverse pipeline of other TIL candidates is in development - find out more in our latest news article https://t.co/blKal3nZzY

[Leonid A. Pobezinsky @pobezinsky]

I am very excited to share our new little story that just came out in Frontiers in Immunology: "The mosquito effect: regulatory and effector T cells acquire cytoplasmic material from tumor cells through intercellular transfer" https://t.co/AxdmFNpw2p

[Noa Tishby @noatishby]

Next week, the University of Michigan (@UMich) is forcing its entire student body to vote on an anti-Israel BDS referendum. They’re essentially making students pick if they are pro-Israel or pro-Palestine. BDS activity on campus has led to a rise in antisemitism on campus. It only causes division on campus and isolates Jewish students. President Ono (@UMichPrezOno) and the university administration must immediately intervene and remove this antisemitic referendum from the ballot.

[Asya Rolls @rolls_asya]

Something is seriously wrong in our society if people feel free removing posters of kidnapped kids

[Felix Yarovinsy @fyarovinsky]

If you need to update an introductory slide for the Immunology class, don't miss this paper:
https://t.co/9Cq27aDNuS

[Journal of Experimental Medicine @JExpMed]

Waipan Chan, Ronald Germain et al. @NIAIDNews show that PD-1 engagement by T cells inhibits distinct antigen-evoked signals in a nonlinear manner, strongly influenced by the nature of available TCR ligands. https://t.co/87qnxmZmjt

#TumorImmunology #LymphocyteBiology

[Nature Rev Immunol @NatRevImmunol]

The effect of physical exercise on anticancer immunity https://t.co/D1LUBMV36s

[Leonid A. Pobezinsky @pobezinsky]

Very cool story!

[Waggoner Lab @LabWaggoner]

Sympathetic stress is connected to tissue innervation and T cell exhaustion, such that blocking β-adrenergic signaling in CD8+ T cells rejuvenates anti-tumor functions @Tcellogic @AnnaGlobig
https://t.co/5F2q1CpEyW

[Vignali Lab @Vignali_Lab]

Regulatory T cells are phenotypically and functionally heterogenous in the TME, but what are the transcriptional networks of functionally suppressive Tregs in the TME?

Our latest work from the lab and first-author @Feng_Shan_ is out now at @SciImmunology! https://t.co/VipvrWy6Q2

[Leonid A. Pobezinsky @pobezinsky]

Our latest paper is finally online! https://t.co/Fhl4TFOrag I am very proud for our three first authors Alex , Constance and Kaito, great job folks!
#tumorimmunology #memory #let7 #lin28

[Leonid A. Pobezinsky @pobezinsky]

@BelkaidLab Congrats!!!

[Elina I. Zúñiga @ZunigaLab]

Don't miss the next #globalimmuno talk tomorrow by Steve Jameson @Jamequistlab and learn about #tcell recirculation and residency 👇

#Immunity @ImmunologyAAI @CytokineSociety @ASImmunology @FAISAfrica @EFIS_Immunology @iuis_online @SocLatAlergia

[Max @MaxKrummel]

Exhausted T cells and Tumor macrophages are symbiotic. @KellyKersten8 shows TAM induce a unique synapse, priming Tex for exhaustion w/o inducing proliferation. Meanwhile Tex attract and promote TAMs. ZipSeq shows this is spatially localized in tumors. https://tinyurl/TAMTex